Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 246437..246930 Replicon chromosome
Accession NZ_CP012366
Organism Enterococcus durans strain KLDS 6.0933

Toxin (Protein)


Gene name relE Uniprot ID A0A2A7SNY0
Locus tag LIANG_RS01170 Protein ID WP_005880058.1
Coordinates 246437..246703 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2A7SN65
Locus tag LIANG_RS01175 Protein ID WP_005880060.1
Coordinates 246700..246930 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIANG_RS01145 (LIANG_01145) 242085..243256 - 1172 Protein_229 radical SAM family heme chaperone HemW -
LIANG_RS01155 (LIANG_01155) 243587..244969 - 1383 WP_053109370.1 site-specific integrase -
LIANG_RS01165 (LIANG_01165) 245528..246229 - 702 WP_034873694.1 hypothetical protein -
LIANG_RS01170 (LIANG_01170) 246437..246703 - 267 WP_005880058.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LIANG_RS01175 (LIANG_01175) 246700..246930 - 231 WP_005880060.1 DUF6290 family protein Antitoxin
LIANG_RS14735 247186..247293 + 108 WP_005880062.1 putative holin-like toxin -
LIANG_RS01180 (LIANG_01180) 247528..247746 - 219 WP_016176477.1 hypothetical protein -
LIANG_RS01185 (LIANG_01185) 247918..248181 - 264 WP_005880066.1 hypothetical protein -
LIANG_RS01190 (LIANG_01190) 248283..249041 - 759 WP_005880068.1 restriction endonuclease -
LIANG_RS01195 (LIANG_01195) 249376..250401 - 1026 WP_016176475.1 HNH endonuclease signature motif containing protein -
LIANG_RS01205 (LIANG_01205) 250620..251746 + 1127 WP_094850654.1 IS3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10563.16 Da        Isoelectric Point: 10.0944

>T56310 WP_005880058.1 NZ_CP012366:c246703-246437 [Enterococcus durans]
VTYHLEFTPEIQKQLRKMDKYQATLIVRWLYQHIDGVDDPRKFGKGLTANRSGQWRYRIGKYRVLVEIEDNQMVVIAIQV
GHRRNVYD

Download         Length: 267 bp

>T56310 NZ_CP012366:c246703-246437 [Enterococcus durans]
GTGACCTATCATTTAGAATTCACGCCTGAAATTCAGAAACAACTTCGTAAAATGGACAAATATCAAGCTACATTGATTGT
TCGATGGCTGTATCAACATATTGATGGCGTTGATGACCCGAGAAAATTCGGGAAAGGGTTGACAGCCAATCGTTCAGGGC
AATGGCGTTATCGGATTGGCAAATATCGAGTGTTGGTAGAAATAGAAGATAATCAAATGGTTGTCATTGCTATTCAAGTG
GGACACCGAAGAAATGTCTATGATTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8850.03 Da        Isoelectric Point: 4.2583

>AT56310 WP_005880060.1 NZ_CP012366:c246930-246700 [Enterococcus durans]
MAMITVRVSDAEKEWLSYMAEFYGITLSELLKTYSMEQLEDEYDRQTAEIAHKHWIESGKPTVSMEEILNEFGGLK

Download         Length: 231 bp

>AT56310 NZ_CP012366:c246930-246700 [Enterococcus durans]
ATGGCTATGATTACTGTACGTGTGAGTGATGCTGAAAAAGAATGGCTTTCTTATATGGCGGAATTTTATGGAATTACTTT
ATCTGAACTATTAAAAACCTATTCGATGGAACAATTAGAAGATGAATATGATCGACAAACAGCTGAAATTGCCCATAAAC
ATTGGATAGAAAGTGGGAAGCCAACTGTATCCATGGAAGAAATACTGAATGAATTTGGAGGACTAAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A7SNY0

Antitoxin

Source ID Structure
AlphaFold DB A0A2A7SN65

References