Detailed information of TA system TA056309

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 1176248..1176918
• Replicon: chromosome
• Accession: NZ_CP012358
• Organism: Oblitimonas alkaliphila strain B4199

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: AKN87_RS05630
• Protein ID: WP_053102753.1
• Coordinates: 1176248..1176673 (-)
• Length: 142 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: AKN87_RS05635
• Protein ID: WP_080995577.1
• Coordinates: 1176673..1176918 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AKN87_RS05605	1171969..1172535	-	567	WP_053102748.1	NAD(P)H-dependent oxidoreductase	-
AKN87_RS05610	1173096..1173320	-	225	WP_053102749.1	type I toxin-antitoxin system ptaRNA1 family toxin	-
AKN87_RS05615	1173383..1173580	-	198	WP_053102750.1	hypothetical protein	-
AKN87_RS05620	1173584..1175122	-	1539	WP_053102751.1	P-type conjugative transfer protein TrbL	-
AKN87_RS12300	1175124..1175276	-	153	WP_158487776.1	hypothetical protein	-
AKN87_RS05625	1175278..1176075	-	798	WP_053102752.1	P-type conjugative transfer protein TrbJ	-
AKN87_RS05630	1176248..1176673	-	426	WP_053102753.1	type II toxin-antitoxin system VapC family toxin	Toxin
AKN87_RS05635	1176673..1176918	-	246	WP_080995577.1	Arc family DNA-binding protein	Antitoxin
AKN87_RS05640	1177713..1178477	-	765	WP_053102755.1	hypothetical protein	-
AKN87_RS05645	1178464..1179315	-	852	WP_053102756.1	helicase RepA family protein	-
AKN87_RS05650	1179317..1179544	-	228	WP_053102757.1	AlpA family phage regulatory protein	-
AKN87_RS05655	1179634..1180611	+	978	WP_053102758.1	LuxR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-124)

Antitoxin

• Arc-like DNA binding domain (9-46)

Sequences

Toxin

Protein

• Length: 142 a.a.
• Molecular weight: 15197.50 Da
• Isoelectric Point: 5.2454

>T56309 WP_053102753.1 NZ_CP012358:c1176673-1176248 [Oblitimonas alkaliphila]
MILLDTNVLSEQFRAKADERVLAWLNDQPLETLYLSAMTVAEIRAGAALMPDGKRKKLLSSRIEERLLPLFAGRVLSFDM
SCTRAYAEVLATAKKSGSGIAAADAVIAATAHEGGFIVATRDTSPFEAAGLKVINPWSESE

Nucleotide

• Length: 426 bp

>T56309 NZ_CP012358:c1176673-1176248 [Oblitimonas alkaliphila]
ATGATTTTGCTTGATACAAATGTTCTATCTGAACAGTTCCGGGCAAAGGCTGATGAGCGTGTTTTGGCCTGGCTGAATGA
CCAGCCACTTGAGACGCTGTATTTGTCTGCAATGACCGTTGCGGAGATTCGCGCAGGTGCTGCGCTGATGCCGGATGGCA
AGCGTAAAAAACTGCTTAGTTCAAGGATTGAAGAAAGGCTGTTGCCGTTGTTTGCAGGGCGTGTGTTGTCGTTTGATATG
TCATGCACAAGAGCTTATGCAGAGGTGCTTGCAACTGCTAAAAAGTCCGGTAGCGGCATTGCAGCTGCAGATGCAGTAAT
AGCAGCAACAGCGCACGAAGGCGGTTTTATTGTTGCAACAAGAGATACAAGCCCGTTTGAAGCAGCGGGATTGAAAGTGA
TTAACCCTTGGAGTGAGAGCGAGTAA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8972.21 Da
• Isoelectric Point: 7.3221

>AT56309 WP_080995577.1 NZ_CP012358:c1176918-1176673 [Oblitimonas alkaliphila]
VRAVTVRDVPEEVHRAIRVRAAQHGRSLQAEMLAIFEQAVKPEGRVKLGNLLGEIGREVKLTDEEAAGFERDHSPARAVS
F

Nucleotide

• Length: 246 bp

>AT56309 NZ_CP012358:c1176918-1176673 [Oblitimonas alkaliphila]
GTGCGAGCAGTAACAGTTCGGGACGTTCCCGAAGAGGTACACAGAGCGATTCGAGTCCGAGCAGCACAACACGGCAGATC
ACTCCAGGCGGAAATGCTGGCCATTTTTGAGCAGGCAGTAAAACCTGAAGGGCGCGTCAAGTTGGGCAATTTGTTGGGCG
AAATCGGGCGTGAAGTAAAACTGACTGATGAAGAAGCAGCAGGTTTTGAACGCGACCACTCACCGGCACGGGCTGTGAGT
TTTTAA