Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 35217..35872 Replicon plasmid pCFSAN000725_01
Accession NZ_CP012348
Organism Salmonella enterica subsp. enterica serovar Pullorum str. ATCC 9120

Toxin (Protein)


Gene name vagD Uniprot ID H9AC96
Locus tag SEEP9120_RS22810 Protein ID WP_001746752.1
Coordinates 35444..35872 (+) Length 143 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID H9AC95
Locus tag SEEP9120_RS22805 Protein ID WP_001261283.1
Coordinates 35217..35447 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SEEP9120_RS22765 30607..31092 - 486 WP_000905606.1 membrane protein -
SEEP9120_RS22770 31086..31595 - 510 WP_001576634.1 CaiF/GrlA family transcriptional regulator -
SEEP9120_RS22775 31599..32312 - 714 Protein_38 EAL domain-containing protein -
SEEP9120_RS22780 32321..33103 - 783 WP_000082169.1 site-specific integrase -
SEEP9120_RS22785 33138..33659 - 522 WP_000198608.1 hypothetical protein -
SEEP9120_RS22790 33656..33946 - 291 WP_001266176.1 hypothetical protein -
SEEP9120_RS22795 33948..34252 - 305 Protein_42 type II toxin-antitoxin system toxin CcdB -
SEEP9120_RS22800 34254..34472 - 219 WP_000813641.1 type II toxin-antitoxin system antitoxin CcdA -
SEEP9120_RS22805 35217..35447 + 231 WP_001261283.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
SEEP9120_RS22810 35444..35872 + 429 WP_001746752.1 type II toxin-antitoxin system VapC family toxin Toxin
SEEP9120_RS22815 36442..37290 - 849 WP_000175397.1 SdiA-regulated domain-containing protein -
SEEP9120_RS25565 37316..37477 - 162 WP_001816720.1 hypothetical protein -
SEEP9120_RS22820 37738..37950 - 213 WP_000063791.1 hypothetical protein -
SEEP9120_RS22825 38023..38607 - 585 WP_024138406.1 hypothetical protein -
SEEP9120_RS24595 38732..39422 - 691 Protein_50 fimbrial protein -
SEEP9120_RS22835 39422..39697 - 276 WP_001020576.1 hypothetical protein -
SEEP9120_RS22840 39684..40448 - 765 WP_001746754.1 minor fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..86650 86650


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 18346.91 Da        Isoelectric Point: 12.9522

>T56308 WP_001746752.1 NZ_CP012348:35444-35872 [Salmonella enterica subsp. enterica serovar Pullorum str. ATCC 9120]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 429 bp

>T56308 NZ_CP012348:35444-35872 [Salmonella enterica subsp. enterica serovar Pullorum str. ATCC 9120]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 9887.42 Da        Isoelectric Point: 12.6808

>AT56308 WP_001261283.1 NZ_CP012348:35217-35447 [Salmonella enterica subsp. enterica serovar Pullorum str. ATCC 9120]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 231 bp

>AT56308 NZ_CP012348:35217-35447 [Salmonella enterica subsp. enterica serovar Pullorum str. ATCC 9120]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A764IXM1

Antitoxin

Source ID Structure
AlphaFold DB A0A6X6R7C5

References