Detailed information of TA system TA056307

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 28629..29254
• Replicon: plasmid pCFSAN000679_01
• Accession: NZ_CP012345
• Organism: Salmonella enterica subsp. enterica serovar Choleraesuis str. ATCC 10708

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: SEEC0708_RS24615
• Protein ID: WP_000911322.1
• Coordinates: 28856..29254 (+)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A8F2UQ48
• Locus tag: SEEC0708_RS24610
• Protein ID: WP_000450263.1
• Coordinates: 28629..28856 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SEEC0708_RS24585	24114..24269	-	156	WP_001719547.1	hypothetical protein	-
SEEC0708_RS24590	24285..24558	-	274	Protein_33	disulfide bond formation protein DsbA	-
SEEC0708_RS24595	24675..25238	-	564	WP_000139307.1	fertility inhibition protein FinO	-
SEEC0708_RS24600	25293..26033	-	741	WP_000177630.1	conjugal transfer pilus acetylase TraX	-
SEEC0708_RS24605	26053..28547	-	2495	Protein_36	conjugative relaxase	-
SEEC0708_RS24610	28629..28856	+	228	WP_000450263.1	toxin-antitoxin system antitoxin VapB	Antitoxin
SEEC0708_RS24615	28856..29254	+	399	WP_000911322.1	tRNA(fMet)-specific endonuclease VapC	Toxin
SEEC0708_RS24620	29263..31488	-	2226	WP_110301494.1	type IV conjugative transfer system coupling protein TraD	-
SEEC0708_RS24625	31860..32591	-	732	WP_001541558.1	complement resistance protein TraT	-
SEEC0708_RS24635	32894..33136	-	243	WP_024131413.1	hypothetical protein	-
SEEC0708_RS24640	33133..33834	-	702	WP_148201696.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..49584	49584

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 17065.17 Da
• Isoelectric Point: 12.9205

>T56307 WP_000911322.1 NZ_CP012345:28856-29254 [Salmonella enterica subsp. enterica serovar Choleraesuis str. ATCC]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 399 bp

>T56307 NZ_CP012345:28856-29254 [Salmonella enterica subsp. enterica serovar Choleraesuis str. ATCC]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 9759.25 Da
• Isoelectric Point: 12.6750

>AT56307 WP_000450263.1 NZ_CP012345:28629-28856 [Salmonella enterica subsp. enterica serovar Choleraesuis str. ATCC]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 228 bp

>AT56307 NZ_CP012345:28629-28856 [Salmonella enterica subsp. enterica serovar Choleraesuis str. ATCC]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA