Detailed information of TA system TA056306

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 11676..12201
• Replicon: plasmid pCFSAN000679_01
• Accession: NZ_CP012345
• Organism: Salmonella enterica subsp. enterica serovar Choleraesuis str. ATCC 10708

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: Q9EUE9
• Locus tag: SEEC0708_RS24490
• Protein ID: WP_001541545.1
• Coordinates: 11676..11981 (-)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: M7S5D0
• Locus tag: SEEC0708_RS24495
• Protein ID: WP_000813641.1
• Coordinates: 11983..12201 (-)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SEEC0708_RS24455	7078..7637	-	560	Protein_9	inverse autotransporter beta domain-containing protein	-
SEEC0708_RS24460	8357..8842	-	486	WP_000905606.1	membrane protein	-
SEEC0708_RS24465	8836..9345	-	510	WP_001541544.1	CaiF/GrlA family transcriptional regulator	-
SEEC0708_RS24470	9272..10040	-	769	Protein_12	EAL domain-containing protein	-
SEEC0708_RS24475	10049..10831	-	783	WP_000082169.1	site-specific integrase	-
SEEC0708_RS24480	10866..11387	-	522	WP_000198608.1	hypothetical protein	-
SEEC0708_RS24485	11384..11674	-	291	WP_001266176.1	hypothetical protein	-
SEEC0708_RS24490	11676..11981	-	306	WP_001541545.1	type II toxin-antitoxin system toxin CcdB	Toxin
SEEC0708_RS24495	11983..12201	-	219	WP_000813641.1	type II toxin-antitoxin system antitoxin CcdA	Antitoxin
SEEC0708_RS24500	12877..13398	+	522	WP_080147800.1	hypothetical protein	-
SEEC0708_RS25000	13442..13870	-	429	Protein_19	hypothetical protein	-
SEEC0708_RS24510	13882..14177	+	296	Protein_20	cytoplasmic protein	-
SEEC0708_RS24515	14671..15660	+	990	WP_000461383.1	RepB family plasmid replication initiator protein	-
SEEC0708_RS24520	15949..16110	-	162	WP_001541548.1	hypothetical protein	-
SEEC0708_RS24525	16163..16549	-	387	WP_001541549.1	YgiW/YdeI family stress tolerance OB fold protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..49584	49584

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (5-92)

Antitoxin

• Cro/C1-type helix-turn-helix domain (20-69)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 15030.03 Da
• Isoelectric Point: 5.5500

>T56306 WP_001541545.1 NZ_CP012345:c11981-11676 [Salmonella enterica subsp. enterica serovar Choleraesuis str. ATCC]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 306 bp

>T56306 NZ_CP012345:c11981-11676 [Salmonella enterica subsp. enterica serovar Choleraesuis str. ATCC]
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Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 10761.91 Da
• Isoelectric Point: 5.5500

>AT56306 WP_000813641.1 NZ_CP012345:c12201-11983 [Salmonella enterica subsp. enterica serovar Choleraesuis str. ATCC]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 219 bp

>AT56306 NZ_CP012345:c12201-11983 [Salmonella enterica subsp. enterica serovar Choleraesuis str. ATCC]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
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TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Structures

Toxin

• AlphaFold DB: Q9EUE9

Antitoxin

• AlphaFold DB: A0A656ICA6