Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 2256760..2257861 Replicon chromosome
Accession NZ_CP012332
Organism Vulgatibacter incomptus strain DSM 27710

Toxin (Protein)


Gene name - Uniprot ID A0A0K1PD87
Locus tag AKJ08_RS09260 Protein ID WP_050725807.1
Coordinates 2257157..2257861 (+) Length 235 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0K1PDC9
Locus tag AKJ08_RS09255 Protein ID WP_050725806.1
Coordinates 2256760..2257137 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AKJ08_RS09240 2252187..2254799 - 2613 WP_082342993.1 PBP1A family penicillin-binding protein -
AKJ08_RS09245 2254811..2255716 - 906 WP_157370588.1 site-specific DNA-methyltransferase -
AKJ08_RS09250 2255674..2256657 - 984 WP_050725805.1 RluA family pseudouridine synthase -
AKJ08_RS09255 2256760..2257137 + 378 WP_050725806.1 DUF2384 domain-containing protein Antitoxin
AKJ08_RS09260 2257157..2257861 + 705 WP_050725807.1 RES family NAD+ phosphorylase Toxin
AKJ08_RS09265 2257872..2259143 - 1272 WP_050725808.1 acetyl-CoA hydrolase/transferase family protein -
AKJ08_RS09270 2259246..2260223 - 978 WP_050725809.1 hypothetical protein -
AKJ08_RS09275 2260367..2261134 + 768 WP_050725810.1 glutathione S-transferase family protein -
AKJ08_RS09280 2261275..2262231 - 957 WP_050725811.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(48-193)

Antitoxin

Cro/C1-type helix-turn-helix domain

(28-58)


Sequences

Toxin        


Download         Length: 235 a.a.        Molecular weight: 26631.24 Da        Isoelectric Point: 8.4615

>T56305 WP_050725807.1 NZ_CP012332:2257157-2257861 [Vulgatibacter incomptus]
VPWRVVEAQHVVSTRKLVDSDADQQLLEELIERHKPPVPREEGFDGLHFLLFSSFRYPPLRHGSRFGSRFEPSLWYGSEE
LRTAFAEVAFYRLRFLEGTEAKLDPLMVELSSFQVRVRSRLAADLTAGTFLARAAELCSKVSYAASQALGRELREAGAEM
IRYASARDERGAANVALFTPRAFAEKRPRTPQTWLCVATRERIELSRKDYFVREVYAFPRSQFEVDGGLPSPSA

Download         Length: 705 bp

>T56305 NZ_CP012332:2257157-2257861 [Vulgatibacter incomptus]
GTGCCCTGGCGCGTGGTCGAAGCCCAGCACGTCGTCTCCACGCGGAAGCTGGTCGACTCCGACGCCGACCAGCAGCTCCT
CGAGGAGCTGATCGAGAGGCACAAGCCGCCGGTCCCTCGCGAGGAGGGCTTCGACGGCCTCCACTTCCTCCTCTTCTCCT
CCTTCCGCTACCCGCCGCTGCGGCACGGCTCCCGCTTTGGGAGCCGCTTCGAGCCCTCGCTCTGGTACGGCTCCGAAGAG
CTCCGCACGGCGTTCGCCGAGGTCGCCTTCTACCGGCTGCGCTTCCTCGAGGGGACCGAAGCGAAGCTGGATCCGCTCAT
GGTCGAGCTCTCCTCGTTCCAGGTGAGGGTGCGCTCGAGGCTCGCCGCCGATCTCACCGCCGGAACCTTCCTCGCGCGGG
CGGCCGAGCTCTGCTCGAAGGTGAGCTACGCCGCCAGCCAGGCCCTGGGGCGTGAGCTTCGCGAGGCCGGCGCGGAGATG
ATCCGCTACGCGTCGGCCCGAGACGAGCGAGGCGCGGCCAACGTGGCCCTCTTCACGCCCAGGGCCTTCGCGGAGAAGCG
CCCGCGTACGCCGCAGACCTGGCTCTGCGTCGCGACGCGCGAGCGCATCGAGCTCTCCCGTAAGGACTACTTCGTCCGCG
AGGTCTACGCCTTCCCCAGGAGCCAGTTCGAGGTGGACGGCGGCCTCCCGTCGCCGAGCGCTTGA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13371.41 Da        Isoelectric Point: 7.2785

>AT56305 WP_050725806.1 NZ_CP012332:2256760-2257137 [Vulgatibacter incomptus]
MTENPQRDAASEASVLTQAVLRAAAIFGLSQKELAAIVGLSPATLSRVASGTSQLRVESKEGELGILFVRIFRSLDALVG
GAKDACRAWLMAYNHHLHGVPLELMQSVRGIVDVAEYLDAIRGRA

Download         Length: 378 bp

>AT56305 NZ_CP012332:2256760-2257137 [Vulgatibacter incomptus]
ATGACCGAGAATCCCCAGCGCGATGCGGCTTCCGAGGCGTCCGTGTTGACCCAGGCCGTCCTGCGGGCTGCCGCGATCTT
CGGGCTCTCCCAGAAGGAGCTCGCGGCGATCGTGGGCTTGAGCCCGGCGACCCTCTCGCGCGTCGCTTCGGGCACGAGCC
AGCTCCGCGTCGAGAGCAAGGAGGGCGAGCTCGGGATCCTCTTCGTACGAATCTTCCGAAGCCTCGATGCCCTCGTCGGC
GGAGCAAAGGACGCCTGCCGTGCGTGGCTGATGGCCTACAACCACCACCTCCACGGCGTCCCGCTGGAGCTGATGCAGAG
CGTGAGGGGGATCGTCGATGTCGCCGAATATCTCGACGCGATCCGCGGAAGGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K1PD87

Antitoxin

Source ID Structure
AlphaFold DB A0A0K1PDC9

References