Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 821838..822495 Replicon chromosome
Accession NZ_CP012300
Organism Klebsiella quasipneumoniae strain HKUOPLC

Toxin (Protein)


Gene name cptA Uniprot ID A0A2A5MNX1
Locus tag AKK42_RS04060 Protein ID WP_004205323.1
Coordinates 822085..822495 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag AKK42_RS04055 Protein ID WP_002916312.1
Coordinates 821838..822104 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AKK42_RS04030 816995..818428 - 1434 WP_049004121.1 6-phospho-beta-glucosidase BglA -
AKK42_RS04035 818547..819275 - 729 WP_004205316.1 MurR/RpiR family transcriptional regulator -
AKK42_RS04040 819325..819636 + 312 WP_004205318.1 N(4)-acetylcytidine aminohydrolase -
AKK42_RS04045 819799..820458 + 660 WP_053809968.1 hemolysin III family protein -
AKK42_RS04050 820609..821592 - 984 WP_017899798.1 tRNA-modifying protein YgfZ -
AKK42_RS04055 821838..822104 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
AKK42_RS04060 822085..822495 + 411 WP_004205323.1 protein YgfX Toxin
AKK42_RS04065 822502..823023 - 522 WP_004205324.1 flavodoxin FldB -
AKK42_RS04070 823124..824020 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
AKK42_RS04075 824043..824756 + 714 WP_004205326.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
AKK42_RS04080 824762..826495 + 1734 WP_004205327.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16035.83 Da        Isoelectric Point: 11.4778

>T56242 WP_004205323.1 NZ_CP012300:822085-822495 [Klebsiella quasipneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
DWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T56242 NZ_CP012300:822085-822495 [Klebsiella quasipneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCTCTGCTGCTCCACGGCGTTGTGGCGGC
GCTGGTGCTGCTGGTTCCCTGGCCGTTAAGCTACACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTTGACTGTG
TGCGCAGCCAGCGACGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGGCTGCGCTGGCAAAACGCC
GACTGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT56242 WP_002916312.1 NZ_CP012300:821838-822104 [Klebsiella quasipneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT56242 NZ_CP012300:821838-822104 [Klebsiella quasipneumoniae]
ATGGACATTAACAATAAAGCTCGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TATTCAACTGGCTGATGAACCATGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A5MNX1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References