Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1527186..1527842 Replicon chromosome
Accession NZ_CP012294
Organism Pediococcus damnosus strain TMW 2.1536

Toxin (Protein)


Gene name hicA Uniprot ID A0A0R2H2Q8
Locus tag ADU73_RS07070 Protein ID WP_046871693.1
Coordinates 1527642..1527842 (-) Length 67 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A143ASQ4
Locus tag ADU73_RS07065 Protein ID WP_046871692.1
Coordinates 1527186..1527620 (-) Length 145 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ADU73_RS07050 1523269..1524699 - 1431 WP_056986240.1 SEC10/PgrA surface exclusion domain-containing protein -
ADU73_RS07055 1525046..1526425 + 1380 WP_052694520.1 hypothetical protein -
ADU73_RS07060 1526440..1527129 + 690 WP_046871691.1 hypothetical protein -
ADU73_RS07065 1527186..1527620 - 435 WP_046871692.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
ADU73_RS07070 1527642..1527842 - 201 WP_046871693.1 type II toxin-antitoxin system HicA family toxin Toxin
ADU73_RS10430 1528099..1528221 - 123 WP_100078054.1 AbrB family transcriptional regulator -
ADU73_RS07075 1528538..1529914 - 1377 WP_056986623.1 ISLre2 family transposase -
ADU73_RS07080 1530099..1531532 + 1434 WP_062913328.1 hypothetical protein -
ADU73_RS10520 1531538..1531687 + 150 WP_158510933.1 hypothetical protein -
ADU73_RS07085 1531789..1532658 - 870 WP_046872188.1 MurR/RpiR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(12-75)


Sequences

Toxin        


Download         Length: 67 a.a.        Molecular weight: 7437.86 Da        Isoelectric Point: 11.0319

>T56241 WP_046871693.1 NZ_CP012294:c1527842-1527642 [Pediococcus damnosus]
MPMTQKQMVKLLKINGWIKSSGGKGSHIKMSKPVKRPITVPHGELNKFTERAIKKEADLESSQLHL

Download         Length: 201 bp

>T56241 NZ_CP012294:c1527842-1527642 [Pediococcus damnosus]
ATGCCGATGACCCAAAAACAAATGGTTAAGTTACTAAAAATTAATGGATGGATCAAATCTTCTGGTGGTAAAGGATCCCA
CATCAAAATGTCGAAACCGGTAAAACGACCTATCACTGTGCCCCATGGGGAGCTTAATAAATTTACTGAACGTGCTATAA
AAAAAGAAGCTGACTTAGAGAGTAGTCAACTTCATTTGTAA

Antitoxin


Download         Length: 145 a.a.        Molecular weight: 16053.36 Da        Isoelectric Point: 6.3391

>AT56241 WP_046871692.1 NZ_CP012294:c1527620-1527186 [Pediococcus damnosus]
MFASYPALFYYDKSEKVPFFITFPDFTNSATQGTSISDAMAMASDWLGITIADSLENNRNLPKPSDIKSLSLKKDNPYPN
DLKYDPALSFVSMVLVDLTGYIDSGQPIKKTLTIPKWADKLGKELKLNFSQTLTDAIANKKLNN

Download         Length: 435 bp

>AT56241 NZ_CP012294:c1527620-1527186 [Pediococcus damnosus]
ATGTTTGCTAGTTATCCAGCGTTATTCTATTATGATAAATCAGAGAAAGTTCCTTTTTTTATCACATTTCCAGATTTCAC
AAACTCGGCCACCCAAGGAACAAGTATTTCTGATGCGATGGCAATGGCTTCTGATTGGCTTGGCATTACGATTGCTGACT
CTTTAGAGAATAATCGTAATTTGCCTAAGCCATCTGATATTAAATCGCTCTCCTTAAAAAAAGATAATCCTTATCCTAAT
GATCTTAAATATGATCCTGCTTTATCCTTTGTTTCAATGGTACTAGTTGATCTAACTGGCTATATTGATTCCGGTCAGCC
AATCAAAAAAACATTAACAATTCCAAAATGGGCCGACAAACTCGGTAAAGAGTTAAAACTAAATTTTTCACAAACGCTAA
CCGATGCTATCGCTAACAAAAAACTAAATAACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R2H2Q8

Antitoxin

Source ID Structure
AlphaFold DB A0A143ASQ4

References