56223

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1046886..1047542 Replicon chromosome
Accession NZ_CP012269
Organism Pediococcus damnosus strain TMW 2.1532

Toxin (Protein)


Gene name hicA Uniprot ID A0A0R2H2Q8
Locus tag ADU69_RS04885 Protein ID WP_046871693.1
Coordinates 1047342..1047542 (-) Length 67 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A143ASQ4
Locus tag ADU69_RS04880 Protein ID WP_046871692.1
Coordinates 1046886..1047320 (-) Length 145 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ADU69_RS04865 1042969..1044399 - 1431 WP_056986240.1 SEC10/PgrA surface exclusion domain-containing protein -
ADU69_RS04870 1044746..1046125 + 1380 WP_052694520.1 hypothetical protein -
ADU69_RS04875 1046140..1046829 + 690 WP_062904014.1 hypothetical protein -
ADU69_RS04880 1046886..1047320 - 435 WP_046871692.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
ADU69_RS04885 1047342..1047542 - 201 WP_046871693.1 type II toxin-antitoxin system HicA family toxin Toxin
ADU69_RS10830 1047799..1047921 - 123 WP_100078054.1 AbrB family transcriptional regulator -
ADU69_RS04890 1048055..1049422 - 1368 WP_046872291.1 ISLre2 family transposase -
ADU69_RS04895 1049598..1051187 + 1590 WP_046872189.1 hypothetical protein -
ADU69_RS04900 1051289..1052158 - 870 WP_046872188.1 MurR/RpiR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(12-75)


Sequences

Toxin        


Download         Length: 67 a.a.        Molecular weight: 7437.86 Da        Isoelectric Point: 11.0319

>T56223 WP_046871693.1 NZ_CP012269:c1047542-1047342 [Pediococcus damnosus]
MPMTQKQMVKLLKINGWIKSSGGKGSHIKMSKPVKRPITVPHGELNKFTERAIKKEADLESSQLHL

Download         Length: 201 bp

>T56223 NZ_CP012269:c1047542-1047342 [Pediococcus damnosus]
ATGCCGATGACCCAAAAACAAATGGTTAAGTTACTAAAAATTAATGGATGGATCAAATCTTCTGGTGGTAAAGGATCCCA
CATCAAAATGTCGAAACCGGTAAAACGACCTATCACTGTGCCCCATGGGGAGCTTAATAAATTTACTGAACGTGCTATAA
AAAAAGAAGCTGACTTAGAGAGTAGTCAACTTCATTTGTAA

Antitoxin


Download         Length: 145 a.a.        Molecular weight: 16053.36 Da        Isoelectric Point: 6.3391

>AT56223 WP_046871692.1 NZ_CP012269:c1047320-1046886 [Pediococcus damnosus]
MFASYPALFYYDKSEKVPFFITFPDFTNSATQGTSISDAMAMASDWLGITIADSLENNRNLPKPSDIKSLSLKKDNPYPN
DLKYDPALSFVSMVLVDLTGYIDSGQPIKKTLTIPKWADKLGKELKLNFSQTLTDAIANKKLNN

Download         Length: 435 bp

>AT56223 NZ_CP012269:c1047320-1046886 [Pediococcus damnosus]
ATGTTTGCTAGTTATCCAGCGTTATTCTATTATGATAAATCAGAGAAAGTTCCTTTTTTTATCACATTTCCAGATTTCAC
AAACTCGGCCACCCAAGGAACAAGTATTTCTGATGCGATGGCAATGGCTTCTGATTGGCTTGGCATTACGATTGCTGACT
CTTTAGAGAATAATCGTAATTTGCCTAAGCCATCTGATATTAAATCGCTCTCCTTAAAAAAAGATAATCCTTATCCTAAT
GATCTTAAATATGATCCTGCTTTATCCTTTGTTTCAATGGTACTAGTTGATCTAACTGGCTATATTGATTCCGGTCAGCC
AATCAAAAAAACATTAACAATTCCAAAATGGGCCGACAAACTCGGTAAAGAGTTAAAACTAAATTTTTCACAAACGCTAA
CCGATGCTATCGCTAATAAAAAACTAAATAACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R2H2Q8

Antitoxin

Source ID Structure
AlphaFold DB A0A143ASQ4

References