Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2886029..2886648 Replicon chromosome
Accession NZ_CP012268
Organism Cronobacter muytjensii ATCC 51329

Toxin (Protein)


Gene name Hha Uniprot ID K8B192
Locus tag AFK63_RS13350 Protein ID WP_007713751.1
Coordinates 2886430..2886648 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A2T7AZ43
Locus tag AFK63_RS13345 Protein ID WP_038864291.1
Coordinates 2886029..2886403 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AFK63_RS13335 2881150..2882355 + 1206 WP_038864289.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
AFK63_RS13340 2882377..2885526 + 3150 WP_038864290.1 multidrug efflux RND transporter permease subunit -
AFK63_RS13345 2886029..2886403 + 375 WP_038864291.1 Hha toxicity modulator TomB Antitoxin
AFK63_RS13350 2886430..2886648 + 219 WP_007713751.1 hemolysin expression modulator Hha Toxin
AFK63_RS13355 2886878..2887429 + 552 WP_038864292.1 maltose O-acetyltransferase -
AFK63_RS13360 2887549..2888058 + 510 WP_038864293.1 YlaC family protein -
AFK63_RS13365 2888087..2888227 - 141 WP_007713754.1 type B 50S ribosomal protein L36 -
AFK63_RS13370 2888231..2888491 - 261 WP_038864295.1 type B 50S ribosomal protein L31 -
AFK63_RS13375 2888637..2890538 - 1902 WP_038864296.1 methyl-accepting chemotaxis protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8624.06 Da        Isoelectric Point: 9.4828

>T56220 WP_007713751.1 NZ_CP012268:2886430-2886648 [Cronobacter muytjensii ATCC 51329]
MTTKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELPDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFVR

Download         Length: 219 bp

>T56220 NZ_CP012268:2886430-2886648 [Cronobacter muytjensii ATCC 51329]
ATGACGACCAAACCATTAACCAAAACCGATTATTTAATGCGACTCAGACGCTGTCAGACAATTGATACGCTGGAACGTGT
GATTGAAAAAAATAAATATGAATTGCCTGACAATGAACTGGCGGTATTTTATTCAGCTGCAGATCATCGTCTCGCTGAAC
TGACCATGAATAAGCTTTACGATAAAATCCCAACCTCTGTGTGGAAATTTGTCCGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14371.06 Da        Isoelectric Point: 4.7168

>AT56220 WP_038864291.1 NZ_CP012268:2886029-2886403 [Cronobacter muytjensii ATCC 51329]
MDEYSPKRHDIAQLKFLCESLYHDCLATLGENQHGWVNDPTSAVNLQLNDLIEHIASFGLNYKIKHDEDAALIEQLDEYL
DDTFMLFSNYGINAQDLQKWRKSGNRLFRCFVNASRENPVSLSF

Download         Length: 375 bp

>AT56220 NZ_CP012268:2886029-2886403 [Cronobacter muytjensii ATCC 51329]
ATGGACGAATACTCACCAAAACGGCATGATATAGCGCAGCTTAAATTTCTTTGCGAAAGCCTGTATCATGATTGCCTCGC
CACGCTAGGCGAAAACCAGCATGGCTGGGTTAACGACCCCACATCCGCCGTTAACCTGCAACTGAACGATCTGATTGAGC
ATATTGCCAGTTTCGGTCTTAATTATAAAATTAAGCATGACGAAGATGCCGCTCTCATTGAGCAATTAGATGAATATCTG
GATGATACTTTTATGCTTTTCAGCAATTACGGTATCAATGCGCAAGATTTGCAAAAATGGCGCAAGTCCGGAAACAGGCT
TTTCCGGTGTTTCGTAAACGCCAGCCGGGAGAATCCTGTGAGCTTGTCTTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K8B192

Antitoxin

Source ID Structure
AlphaFold DB A0A2T7AZ43

References