Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 478596..479259 Replicon chromosome
Accession NZ_CP012268
Organism Cronobacter muytjensii ATCC 51329

Toxin (Protein)


Gene name cptA Uniprot ID A0A2T7API2
Locus tag AFK63_RS02345 Protein ID WP_038868005.1
Coordinates 478843..479259 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A2T7API5
Locus tag AFK63_RS02340 Protein ID WP_038868003.1
Coordinates 478596..478862 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AFK63_RS02320 475160..475888 - 729 WP_038867994.1 MurR/RpiR family transcriptional regulator -
AFK63_RS02325 476067..476381 + 315 WP_038867996.1 N(4)-acetylcytidine aminohydrolase -
AFK63_RS02330 476546..477199 + 654 WP_038867998.1 hemolysin III family protein -
AFK63_RS02335 477330..478319 - 990 WP_038868000.1 tRNA-modifying protein YgfZ -
AFK63_RS02340 478596..478862 + 267 WP_038868003.1 FAD assembly factor SdhE Antitoxin
AFK63_RS02345 478843..479259 + 417 WP_038868005.1 protein YgfX Toxin
AFK63_RS02350 479291..479812 - 522 WP_038868007.1 flavodoxin FldB -
AFK63_RS02355 479914..480810 + 897 WP_038868009.1 site-specific tyrosine recombinase XerD -
AFK63_RS02360 480833..481552 + 720 WP_038868012.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
AFK63_RS02365 481556..483289 + 1734 WP_038868014.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 16366.34 Da        Isoelectric Point: 11.6942

>T56210 WP_038868005.1 NZ_CP012268:478843-479259 [Cronobacter muytjensii ATCC 51329]
VVLWHSDLRVSWRSQWVSLLLHGAVAVIILLLPWPLRYLPVWMLLLSLVVFDCVRSQRRINAFQGEVSLTADYQLRWQGI
DWEICATPWMLRSGMMMRLRHPKTTRSHHVWLASDSMTPAEWRDLRRLLLQQPVRGSR

Download         Length: 417 bp

>T56210 NZ_CP012268:478843-479259 [Cronobacter muytjensii ATCC 51329]
GTGGTCCTGTGGCACTCTGATCTTCGCGTCTCATGGCGCTCTCAGTGGGTGTCGCTGCTGCTGCATGGCGCTGTGGCCGT
TATTATTTTGTTGCTTCCTTGGCCGCTGCGGTATCTGCCCGTCTGGATGTTGCTGCTGTCGCTGGTGGTGTTTGACTGCG
TTCGCAGTCAGCGACGTATCAACGCTTTTCAGGGGGAGGTCAGCCTCACGGCGGACTATCAGCTACGCTGGCAGGGCATC
GACTGGGAGATTTGCGCCACGCCCTGGATGTTACGCAGCGGCATGATGATGCGCCTGCGCCATCCCAAAACGACGCGCAG
CCACCATGTGTGGCTGGCATCGGACAGCATGACGCCGGCAGAGTGGCGGGATTTGCGTCGACTGTTACTGCAACAGCCGG
TGCGGGGTAGCCGTTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10440.94 Da        Isoelectric Point: 5.1295

>AT56210 WP_038868003.1 NZ_CP012268:478596-478862 [Cronobacter muytjensii ATCC 51329]
MDINNKARIHWACRRGMRELDISIMPFFEHDYDALSEEDKRVFVRLLECDDPDLFNWLMNHGKPADAELARMVQLIQQRN
QERGPVAL

Download         Length: 267 bp

>AT56210 NZ_CP012268:478596-478862 [Cronobacter muytjensii ATCC 51329]
ATGGATATTAACAATAAAGCCCGTATTCACTGGGCATGTCGCAGAGGTATGCGTGAGCTGGATATTTCCATCATGCCTTT
CTTTGAGCACGACTATGACGCTCTGAGCGAAGAAGACAAACGCGTCTTTGTCCGCCTGCTGGAGTGTGACGACCCTGATT
TATTCAACTGGCTGATGAACCACGGCAAACCTGCCGATGCGGAACTGGCGCGGATGGTGCAATTGATCCAGCAACGGAAT
CAGGAACGTGGTCCTGTGGCACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2T7API2

Antitoxin

Source ID Structure
AlphaFold DB A0A2T7API5

References