Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/Doc-RelB |
| Location | 4172007..4172596 | Replicon | chromosome |
| Accession | NZ_CP012266 | ||
| Organism | Cronobacter dublinensis subsp. dublinensis LMG 23823 | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | K8AR47 |
| Locus tag | AFK67_RS19355 | Protein ID | WP_007730581.1 |
| Coordinates | 4172007..4172375 (-) | Length | 123 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | K8BAC3 |
| Locus tag | AFK67_RS19360 | Protein ID | WP_007730583.1 |
| Coordinates | 4172375..4172596 (-) | Length | 74 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AFK67_RS19335 | 4167583..4168656 | - | 1074 | WP_007730573.1 | sn-glycerol-3-phosphate import ATP-binding protein UgpC | - |
| AFK67_RS19340 | 4168658..4169503 | - | 846 | WP_007730575.1 | sn-glycerol-3-phosphate ABC transporter permease UgpE | - |
| AFK67_RS19345 | 4169500..4170387 | - | 888 | WP_007730578.1 | sn-glycerol-3-phosphate ABC transporter permease UgpA | - |
| AFK67_RS19350 | 4170517..4171836 | - | 1320 | WP_032967603.1 | sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB | - |
| AFK67_RS19355 | 4172007..4172375 | - | 369 | WP_007730581.1 | type II toxin-antitoxin system death-on-curing family toxin | Toxin |
| AFK67_RS19360 | 4172375..4172596 | - | 222 | WP_007730583.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| AFK67_RS19365 | 4172729..4173442 | - | 714 | WP_007730585.1 | high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF | - |
| AFK67_RS19370 | 4173444..4174211 | - | 768 | WP_007730587.1 | high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG | - |
| AFK67_RS19375 | 4174208..4175488 | - | 1281 | WP_007730589.1 | high-affinity branched-chain amino acid ABC transporter permease LivM | - |
| AFK67_RS19380 | 4175485..4176411 | - | 927 | WP_007730591.1 | high-affinity branched-chain amino acid ABC transporter permease LivH | - |
| AFK67_RS19385 | 4176475..4176726 | - | 252 | WP_007730593.1 | hypothetical protein | - |
| AFK67_RS19390 | 4177147..4177539 | + | 393 | WP_007730596.1 | aspartate 1-decarboxylase autocleavage activator PanM | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 4166328..4175488 | 9160 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 123 a.a. Molecular weight: 13502.82 Da Isoelectric Point: 6.8798
>T56208 WP_007730581.1 NZ_CP012266:c4172375-4172007 [Cronobacter dublinensis subsp. dublinensis LMG 23823]
MTIHFISAEEIVRFHDRLLQVTPGVTGMPDPGRAEALMYRVLNKYEYEGVDDIWLLAAMHLLAIARGHIFNDGNKRTALF
ITLLFLKRNGIALAANPAFVEMTVDAAAGRLSLEAIAALLRP
MTIHFISAEEIVRFHDRLLQVTPGVTGMPDPGRAEALMYRVLNKYEYEGVDDIWLLAAMHLLAIARGHIFNDGNKRTALF
ITLLFLKRNGIALAANPAFVEMTVDAAAGRLSLEAIAALLRP
Download Length: 369 bp
>T56208 NZ_CP012266:c4172375-4172007 [Cronobacter dublinensis subsp. dublinensis LMG 23823]
ATGACGATTCACTTTATCTCAGCGGAGGAGATAGTTCGTTTCCATGACCGCTTATTGCAGGTGACGCCCGGCGTCACAGG
GATGCCCGACCCGGGGCGGGCCGAAGCGTTAATGTATCGCGTGCTTAATAAATATGAGTACGAAGGCGTTGACGATATCT
GGCTGCTGGCGGCGATGCATTTGCTGGCGATTGCGCGAGGCCATATTTTCAACGACGGTAATAAGCGCACGGCGCTTTTC
ATTACGCTGTTGTTTCTTAAGCGAAACGGTATTGCGCTTGCGGCTAATCCGGCTTTTGTTGAGATGACGGTCGACGCGGC
GGCAGGTCGGCTTTCACTGGAAGCGATAGCTGCGTTGCTTCGCCCCTGA
ATGACGATTCACTTTATCTCAGCGGAGGAGATAGTTCGTTTCCATGACCGCTTATTGCAGGTGACGCCCGGCGTCACAGG
GATGCCCGACCCGGGGCGGGCCGAAGCGTTAATGTATCGCGTGCTTAATAAATATGAGTACGAAGGCGTTGACGATATCT
GGCTGCTGGCGGCGATGCATTTGCTGGCGATTGCGCGAGGCCATATTTTCAACGACGGTAATAAGCGCACGGCGCTTTTC
ATTACGCTGTTGTTTCTTAAGCGAAACGGTATTGCGCTTGCGGCTAATCCGGCTTTTGTTGAGATGACGGTCGACGCGGC
GGCAGGTCGGCTTTCACTGGAAGCGATAGCTGCGTTGCTTCGCCCCTGA
Antitoxin
Download Length: 74 a.a. Molecular weight: 8168.20 Da Isoelectric Point: 5.6746
>AT56208 WP_007730583.1 NZ_CP012266:c4172596-4172375 [Cronobacter dublinensis subsp. dublinensis LMG 23823]
MRTMNYSEARQQLASALESATTGTPVTITRRGHKPAVIISAEEFERYQAAKLDAEFAEMMAVHGNEIRELADR
MRTMNYSEARQQLASALESATTGTPVTITRRGHKPAVIISAEEFERYQAAKLDAEFAEMMAVHGNEIRELADR
Download Length: 222 bp
>AT56208 NZ_CP012266:c4172596-4172375 [Cronobacter dublinensis subsp. dublinensis LMG 23823]
ATGCGTACGATGAACTACAGCGAAGCGCGCCAGCAGCTCGCTTCCGCCCTGGAATCCGCCACCACCGGAACGCCAGTGAC
CATTACGCGCCGCGGCCATAAACCGGCCGTTATCATCAGCGCCGAAGAGTTTGAACGTTACCAGGCGGCCAAACTGGATG
CCGAATTCGCGGAGATGATGGCCGTGCACGGTAATGAAATCAGGGAGCTTGCGGACAGGTAA
ATGCGTACGATGAACTACAGCGAAGCGCGCCAGCAGCTCGCTTCCGCCCTGGAATCCGCCACCACCGGAACGCCAGTGAC
CATTACGCGCCGCGGCCATAAACCGGCCGTTATCATCAGCGCCGAAGAGTTTGAACGTTACCAGGCGGCCAAACTGGATG
CCGAATTCGCGGAGATGATGGCCGTGCACGGTAATGAAATCAGGGAGCTTGCGGACAGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|