Detailed information of TA system TA056207

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3656729..3657389
• Replicon: chromosome
• Accession: NZ_CP012266
• Organism: Cronobacter dublinensis subsp. dublinensis LMG 23823

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: AFK67_RS16890
• Protein ID: WP_032967004.1
• Coordinates: 3656729..3657142 (-)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: K8AL19
• Locus tag: AFK67_RS16895
• Protein ID: WP_007718966.1
• Coordinates: 3657123..3657389 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AFK67_RS16870	3652715..3654448	-	1734	WP_007718979.1	single-stranded-DNA-specific exonuclease RecJ	-
AFK67_RS16875	3654452..3655171	-	720	WP_007752085.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
AFK67_RS16880	3655194..3656090	-	897	WP_032967006.1	site-specific tyrosine recombinase XerD	-
AFK67_RS16885	3656192..3656713	+	522	WP_007718971.1	flavodoxin FldB	-
AFK67_RS16890	3656729..3657142	-	414	WP_032967004.1	protein YgfX	Toxin
AFK67_RS16895	3657123..3657389	-	267	WP_007718966.1	FAD assembly factor SdhE	Antitoxin
AFK67_RS16900	3657667..3658656	+	990	WP_007718964.1	tRNA-modifying protein YgfZ	-
AFK67_RS16905	3658787..3659440	-	654	WP_007718962.1	hemolysin III family protein	-
AFK67_RS16910	3659605..3659919	-	315	WP_007718961.1	N(4)-acetylcytidine aminohydrolase	-
AFK67_RS16915	3660097..3660825	+	729	WP_032967003.1	MurR/RpiR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 16287.27 Da
• Isoelectric Point: 11.7170

>T56207 WP_032967004.1 NZ_CP012266:c3657142-3656729 [Cronobacter dublinensis subsp. dublinensis LMG 23823]
VVLWHSDLRVSWRSQWVSLLLHGAVAVIILLLPWPLRYLPVWMLLLSLVVFDCVRSQRRINAFHGEVSLTADYQLRWQGV
DWEICATPWMLRSGMMLRLRHPKTTRSHHVWLASDSMTAKEWRDLRRLLLQQPVRGR

Nucleotide

• Length: 414 bp

>T56207 NZ_CP012266:c3657142-3656729 [Cronobacter dublinensis subsp. dublinensis LMG 23823]
GTGGTCCTGTGGCACTCTGATCTTCGCGTCTCATGGCGCTCGCAGTGGGTGTCGTTGCTGCTGCATGGCGCGGTAGCCGT
GATTATTTTGCTGCTTCCGTGGCCGCTGCGGTATCTGCCCGTCTGGATGCTGCTGCTGTCTCTGGTGGTGTTTGACTGCG
TTCGCAGCCAGCGGCGTATCAATGCGTTTCACGGAGAGGTCAGCCTGACGGCGGACTATCAGCTACGCTGGCAGGGCGTT
GACTGGGAGATCTGCGCGACGCCCTGGATGCTGCGCAGCGGCATGATGCTGCGTCTTCGGCATCCAAAAACGACGCGCAG
CCACCATGTGTGGCTGGCATCGGACAGTATGACGGCGAAGGAATGGCGCGATTTGCGTCGGCTTTTACTACAGCAGCCGG
TGCGGGGCCGCTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10456.94 Da
• Isoelectric Point: 5.1295

>AT56207 WP_007718966.1 NZ_CP012266:c3657389-3657123 [Cronobacter dublinensis subsp. dublinensis LMG 23823]
MDINNKARIHWACRRGMRELDISIMPFFEHDYDSLSEEDKRVFVRLLECDDPDLFNWLMNHGKPADAELARMVQLIQQRN
QERGPVAL

Nucleotide

• Length: 267 bp

>AT56207 NZ_CP012266:c3657389-3657123 [Cronobacter dublinensis subsp. dublinensis LMG 23823]
ATGGATATTAATAATAAAGCCCGTATTCACTGGGCATGTCGCAGAGGTATGCGTGAGCTGGACATTTCCATCATGCCTTT
CTTTGAGCACGACTATGACTCCCTGAGCGAAGAAGACAAACGCGTCTTTGTGCGCCTGCTGGAGTGTGACGATCCTGATT
TATTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAACTGGCGCGGATGGTGCAATTGATCCAACAACGGAAT
CAGGAACGTGGTCCTGTGGCACTCTGA

Structures

Antitoxin

• AlphaFold DB: K8AL19