Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 3016087..3016739 | Replicon | chromosome |
| Accession | NZ_CP012266 | ||
| Organism | Cronobacter dublinensis subsp. dublinensis LMG 23823 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | - |
| Locus tag | AFK67_RS22105 | Protein ID | WP_071602705.1 |
| Coordinates | 3016087..3016269 (+) | Length | 61 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | K8APS2 |
| Locus tag | AFK67_RS13825 | Protein ID | WP_007728176.1 |
| Coordinates | 3016326..3016739 (+) | Length | 138 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AFK67_RS23080 | 3011504..3012289 | + | 786 | WP_038883206.1 | hypothetical protein | - |
| AFK67_RS22100 | 3012549..3012728 | - | 180 | WP_200863221.1 | phage tail assembly chaperone | - |
| AFK67_RS13800 | 3013447..3013893 | - | 447 | WP_032967679.1 | hypothetical protein | - |
| AFK67_RS13805 | 3014146..3014610 | - | 465 | WP_032806383.1 | lysis protein | - |
| AFK67_RS13810 | 3014610..3015233 | - | 624 | WP_053532902.1 | glycoside hydrolase family 19 protein | - |
| AFK67_RS13815 | 3015230..3015514 | - | 285 | WP_007709085.1 | phage holin family protein | - |
| AFK67_RS13820 | 3015501..3015881 | - | 381 | WP_007747946.1 | phage holin family protein | - |
| AFK67_RS22105 | 3016087..3016269 | + | 183 | WP_071602705.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| AFK67_RS13825 | 3016326..3016739 | + | 414 | WP_007728176.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| AFK67_RS13830 | 3016922..3017680 | - | 759 | WP_007728178.1 | antitermination protein | - |
| AFK67_RS13835 | 3017699..3018748 | - | 1050 | WP_038883193.1 | DUF968 domain-containing protein | - |
| AFK67_RS13840 | 3018745..3019470 | - | 726 | WP_050555368.1 | phage antirepressor KilAC domain-containing protein | - |
| AFK67_RS13845 | 3019486..3019869 | - | 384 | WP_038883190.1 | RusA family crossover junction endodeoxyribonuclease | - |
| AFK67_RS13850 | 3019866..3020195 | - | 330 | WP_007728842.1 | SOS-response repressor and protease LexA | - |
| AFK67_RS13855 | 3020192..3021370 | - | 1179 | WP_007728839.1 | phage N-6-adenine-methyltransferase | - |
| AFK67_RS13860 | 3021370..3021606 | - | 237 | WP_007728837.1 | PerC family transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 3003044..3029512 | 26468 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 61 a.a. Molecular weight: 6806.00 Da Isoelectric Point: 11.0007
>T56206 WP_071602705.1 NZ_CP012266:3016087-3016269 [Cronobacter dublinensis subsp. dublinensis LMG 23823]
MKSSELIRLLEEHGWTLVRIKGSHHTFKHPDSPNLVTVPHPSKEIKTGTLRQVLKKAGIK
MKSSELIRLLEEHGWTLVRIKGSHHTFKHPDSPNLVTVPHPSKEIKTGTLRQVLKKAGIK
Download Length: 183 bp
>T56206 NZ_CP012266:3016087-3016269 [Cronobacter dublinensis subsp. dublinensis LMG 23823]
TTGAAGAGTTCGGAACTGATAAGGCTGTTAGAAGAACATGGCTGGACGTTGGTAAGGATTAAAGGCAGTCACCACACGTT
CAAACATCCAGATTCTCCTAACCTTGTGACAGTACCCCATCCCAGCAAAGAGATTAAAACCGGAACCCTTCGGCAAGTAC
TCAAAAAAGCAGGGATCAAGTAA
TTGAAGAGTTCGGAACTGATAAGGCTGTTAGAAGAACATGGCTGGACGTTGGTAAGGATTAAAGGCAGTCACCACACGTT
CAAACATCCAGATTCTCCTAACCTTGTGACAGTACCCCATCCCAGCAAAGAGATTAAAACCGGAACCCTTCGGCAAGTAC
TCAAAAAAGCAGGGATCAAGTAA
Antitoxin
Download Length: 138 a.a. Molecular weight: 14965.74 Da Isoelectric Point: 5.1675
>AT56206 WP_007728176.1 NZ_CP012266:3016326-3016739 [Cronobacter dublinensis subsp. dublinensis LMG 23823]
MHYPAFIEIDKDGSASGWFPDVDGCIFAGDTVEEAIADARSAIDAHFEALAENDMAIPNAGKMQEHIAKDAAAYKNGQWV
LIPVNMDKFDGRAERINITLPHRLLHQIDSAVKNNPSYSSRSAFIAAATRNELHKAG
MHYPAFIEIDKDGSASGWFPDVDGCIFAGDTVEEAIADARSAIDAHFEALAENDMAIPNAGKMQEHIAKDAAAYKNGQWV
LIPVNMDKFDGRAERINITLPHRLLHQIDSAVKNNPSYSSRSAFIAAATRNELHKAG
Download Length: 414 bp
>AT56206 NZ_CP012266:3016326-3016739 [Cronobacter dublinensis subsp. dublinensis LMG 23823]
ATGCATTACCCAGCATTTATTGAGATAGATAAAGACGGATCCGCCAGCGGGTGGTTTCCTGATGTTGATGGCTGTATCTT
CGCCGGGGATACGGTCGAAGAAGCTATTGCCGACGCCAGAAGCGCAATTGATGCGCACTTCGAAGCGTTAGCAGAAAATG
ATATGGCGATACCGAACGCCGGTAAGATGCAGGAGCACATCGCAAAAGATGCCGCAGCGTATAAGAACGGCCAGTGGGTT
CTGATCCCGGTCAACATGGACAAATTCGATGGTCGCGCGGAAAGAATAAATATCACCTTGCCGCATCGGTTATTGCACCA
AATCGATAGCGCGGTAAAAAATAACCCGTCATATAGCAGCAGAAGCGCATTTATTGCGGCTGCTACGCGCAACGAGTTGC
ATAAAGCAGGCTAA
ATGCATTACCCAGCATTTATTGAGATAGATAAAGACGGATCCGCCAGCGGGTGGTTTCCTGATGTTGATGGCTGTATCTT
CGCCGGGGATACGGTCGAAGAAGCTATTGCCGACGCCAGAAGCGCAATTGATGCGCACTTCGAAGCGTTAGCAGAAAATG
ATATGGCGATACCGAACGCCGGTAAGATGCAGGAGCACATCGCAAAAGATGCCGCAGCGTATAAGAACGGCCAGTGGGTT
CTGATCCCGGTCAACATGGACAAATTCGATGGTCGCGCGGAAAGAATAAATATCACCTTGCCGCATCGGTTATTGCACCA
AATCGATAGCGCGGTAAAAAATAACCCGTCATATAGCAGCAGAAGCGCATTTATTGCGGCTGCTACGCGCAACGAGTTGC
ATAAAGCAGGCTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|