Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/UPF0150(antitoxin) |
| Location | 2649418..2650051 | Replicon | chromosome |
| Accession | NZ_CP012266 | ||
| Organism | Cronobacter dublinensis subsp. dublinensis LMG 23823 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | - |
| Locus tag | AFK67_RS22030 | Protein ID | WP_032967702.1 |
| Coordinates | 2649875..2650051 (-) | Length | 59 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | K8B5F0 |
| Locus tag | AFK67_RS12045 | Protein ID | WP_007734261.1 |
| Coordinates | 2649418..2649825 (-) | Length | 136 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AFK67_RS12010 | 2644792..2645310 | + | 519 | WP_032967287.1 | hypothetical protein | - |
| AFK67_RS12015 | 2645465..2646922 | - | 1458 | WP_038883348.1 | glycosyltransferase | - |
| AFK67_RS12020 | 2646970..2647386 | - | 417 | WP_032967286.1 | hypothetical protein | - |
| AFK67_RS12025 | 2647574..2648056 | - | 483 | WP_050555353.1 | lysis protein | - |
| AFK67_RS12030 | 2648056..2648679 | - | 624 | WP_053532898.1 | glycoside hydrolase family 19 protein | - |
| AFK67_RS12035 | 2648676..2648960 | - | 285 | WP_007709085.1 | phage holin family protein | - |
| AFK67_RS12040 | 2648947..2649327 | - | 381 | WP_007734264.1 | phage holin family protein | - |
| AFK67_RS12045 | 2649418..2649825 | - | 408 | WP_007734261.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| AFK67_RS22030 | 2649875..2650051 | - | 177 | WP_032967702.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| AFK67_RS12050 | 2650228..2650917 | - | 690 | WP_007734259.1 | antiterminator-like protein | - |
| AFK67_RS12055 | 2651081..2651446 | - | 366 | WP_032967701.1 | RusA family crossover junction endodeoxyribonuclease | - |
| AFK67_RS12060 | 2651443..2651733 | - | 291 | WP_032967700.1 | DUF1364 domain-containing protein | - |
| AFK67_RS22865 | 2651726..2651893 | - | 168 | WP_032967699.1 | hypothetical protein | - |
| AFK67_RS12065 | 2652167..2652622 | - | 456 | WP_007734254.1 | YbcN family protein | - |
| AFK67_RS12070 | 2652917..2653765 | + | 849 | WP_134792955.1 | hypothetical protein | - |
| AFK67_RS12075 | 2653975..2654196 | - | 222 | WP_032967697.1 | hypothetical protein | - |
| AFK67_RS12080 | 2654193..2654897 | - | 705 | WP_007734253.1 | phage DNA replication protein P | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2619762..2687941 | 68179 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 59 a.a. Molecular weight: 6719.78 Da Isoelectric Point: 11.2092
>T56196 WP_032967702.1 NZ_CP012266:c2650051-2649875 [Cronobacter dublinensis subsp. dublinensis LMG 23823]
VKQSEFRRWLESQGVEVSNGTNHLKLKHNGKRSVMPRHPSDEIKESLRKAILKQLGLK
VKQSEFRRWLESQGVEVSNGTNHLKLKHNGKRSVMPRHPSDEIKESLRKAILKQLGLK
Download Length: 177 bp
>T56196 NZ_CP012266:c2650051-2649875 [Cronobacter dublinensis subsp. dublinensis LMG 23823]
GTGAAGCAAAGCGAGTTCAGGCGGTGGCTTGAATCTCAGGGAGTTGAAGTTTCAAACGGTACCAACCACCTGAAACTGAA
ACACAACGGGAAGCGAAGCGTAATGCCGAGACACCCGAGCGATGAGATTAAAGAATCACTGAGAAAGGCAATACTCAAGC
AGTTAGGCCTTAAATAA
GTGAAGCAAAGCGAGTTCAGGCGGTGGCTTGAATCTCAGGGAGTTGAAGTTTCAAACGGTACCAACCACCTGAAACTGAA
ACACAACGGGAAGCGAAGCGTAATGCCGAGACACCCGAGCGATGAGATTAAAGAATCACTGAGAAAGGCAATACTCAAGC
AGTTAGGCCTTAAATAA
Antitoxin
Download Length: 136 a.a. Molecular weight: 14711.78 Da Isoelectric Point: 4.4829
>AT56196 WP_007734261.1 NZ_CP012266:c2649825-2649418 [Cronobacter dublinensis subsp. dublinensis LMG 23823]
MRYPVKLEPDSGGYFVSFPDIPEALTQGDNREEALAMALDALVTSFDFYFEDGRAVPDPSAVTGDFVEVPTSVAAKVILL
NTFLDSGLTQVELAVRMGIKKQEVTRLFDLHHSTKIDTIQKALAALGKSLELHAA
MRYPVKLEPDSGGYFVSFPDIPEALTQGDNREEALAMALDALVTSFDFYFEDGRAVPDPSAVTGDFVEVPTSVAAKVILL
NTFLDSGLTQVELAVRMGIKKQEVTRLFDLHHSTKIDTIQKALAALGKSLELHAA
Download Length: 408 bp
>AT56196 NZ_CP012266:c2649825-2649418 [Cronobacter dublinensis subsp. dublinensis LMG 23823]
ATGCGATACCCCGTAAAACTTGAGCCGGATTCCGGCGGCTACTTTGTCTCTTTCCCGGATATCCCCGAAGCATTAACGCA
GGGGGACAACCGCGAAGAGGCGCTGGCAATGGCGCTTGATGCGCTTGTGACATCTTTCGACTTTTATTTCGAGGATGGCC
GGGCGGTGCCTGATCCGTCGGCAGTGACTGGTGATTTTGTTGAGGTACCTACCAGCGTGGCGGCAAAAGTGATACTGCTT
AATACCTTTCTTGATTCCGGCTTAACTCAGGTTGAGCTGGCGGTGCGCATGGGTATTAAAAAGCAGGAAGTGACGCGTCT
GTTTGACCTGCATCACTCAACAAAGATCGACACCATCCAGAAAGCGCTGGCGGCGCTCGGTAAGTCACTAGAGCTTCACG
CCGCGTAA
ATGCGATACCCCGTAAAACTTGAGCCGGATTCCGGCGGCTACTTTGTCTCTTTCCCGGATATCCCCGAAGCATTAACGCA
GGGGGACAACCGCGAAGAGGCGCTGGCAATGGCGCTTGATGCGCTTGTGACATCTTTCGACTTTTATTTCGAGGATGGCC
GGGCGGTGCCTGATCCGTCGGCAGTGACTGGTGATTTTGTTGAGGTACCTACCAGCGTGGCGGCAAAAGTGATACTGCTT
AATACCTTTCTTGATTCCGGCTTAACTCAGGTTGAGCTGGCGGTGCGCATGGGTATTAAAAAGCAGGAAGTGACGCGTCT
GTTTGACCTGCATCACTCAACAAAGATCGACACCATCCAGAAAGCGCTGGCGGCGCTCGGTAAGTCACTAGAGCTTCACG
CCGCGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|