Detailed information of TA system TA056192

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 9634..11240
• Replicon: plasmid pCCO1
• Accession: NZ_CP012265
• Organism: Cronobacter condimenti 1330 strain LMG 26250

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: K8A025
• Locus tag: AFK62_RS19990
• Protein ID: WP_007669577.1
• Coordinates: 9634..10953 (-)
• Length: 440 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: AFK62_RS19995
• Protein ID: WP_007669594.1
• Coordinates: 10956..11240 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AFK62_RS19980	5016..7547	-	2532	WP_007669574.1	malto-oligosyltrehalose synthase	-
AFK62_RS19985	7544..9328	-	1785	WP_053532127.1	malto-oligosyltrehalose trehalohydrolase	-
AFK62_RS19990	9634..10953	-	1320	WP_007669577.1	type II toxin-antitoxin system HipA family toxin	Toxin
AFK62_RS19995	10956..11240	-	285	WP_007669594.1	helix-turn-helix domain-containing protein	Antitoxin
AFK62_RS20000	11366..12253	-	888	WP_007669598.1	siderophore-interacting protein	-
AFK62_RS20005	12250..13461	-	1212	WP_007669601.1	MFS transporter	-
AFK62_RS20010	13597..15345	+	1749	WP_007669604.1	citrate:6-N-acetyl-6-N-hydroxy-L-lysine ligase subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	iucA / iucB / iucC / iutA / mgtB	1..151491	151491

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (7-107)

Antitoxin

• Cro/C1-type helix-turn-helix domain (21-69)

Sequences

Toxin

Protein

• Length: 440 a.a.
• Molecular weight: 49495.65 Da
• Isoelectric Point: 7.7475

>T56192 WP_007669577.1 NZ_CP012265:c10953-9634 [Cronobacter condimenti 1330]
MRRTPRLAIWMNGIPVGYWDKHLGDDRLEYLPEWTEDAQGRPLSLSLPFTPGNQPYRGTRVRDYFDNLLPDSEGIRRRLA
MRYQAHSLDPFDLLAELGRDCVGAIQLLRADEQPEGLFAIRARPLSTVDIAAMLRHTAQAFPGQQGEEETLRLSIAGAQE
KTALLWHNGQWCLPEGNTPTTHIFKLPLGLVGNMQADMRTSIENEWLCSQLLAAYDIPVARTQMAQFEEQKVLIVERFDR
RLSRDKQWWLRLPQEDMCQALGVSPLRKYQSDGGPGIGDIMTILSRSEQARADRATFFRAQIVFWILAATDGHAKNFSIA
HLPGNRYHLTPLYDVLSAWPVIGPGNNQIAWQKCKLAMAVRGSSNYYHLSQIRRRHWLRQGELAGLSHAQVTAMVDALIA
ATPDVIDRVAAALPAGFPLALAEQIFEGMRQQCARLANA

Nucleotide

• Length: 1320 bp

>T56192 NZ_CP012265:c10953-9634 [Cronobacter condimenti 1330]
ATGCGCCGCACGCCGCGTTTAGCTATCTGGATGAACGGGATCCCGGTCGGCTACTGGGATAAACACCTCGGGGACGATCG
GCTGGAATACCTGCCGGAATGGACGGAGGACGCGCAGGGCCGACCGCTGTCTTTGTCGCTGCCGTTCACCCCGGGCAACC
AGCCGTATCGCGGCACGCGGGTGCGGGATTACTTCGATAACCTGTTGCCGGACAGCGAAGGCATCCGTCGCCGCCTGGCG
ATGCGTTACCAGGCGCACAGCCTCGACCCGTTCGATTTGCTGGCGGAACTGGGACGCGACTGCGTTGGCGCCATCCAGCT
GCTGCGCGCTGATGAACAGCCGGAAGGCCTGTTTGCCATTCGCGCTCGCCCGCTCTCCACAGTGGATATTGCCGCGATGC
TGCGCCATACCGCCCAGGCGTTTCCCGGCCAGCAGGGTGAAGAGGAGACGCTGCGGCTCTCTATCGCAGGCGCACAGGAG
AAAACCGCGCTGCTGTGGCACAACGGTCAGTGGTGTCTGCCGGAGGGCAACACGCCCACAACGCATATCTTCAAACTTCC
GCTGGGACTGGTGGGCAATATGCAGGCGGATATGCGCACGTCGATTGAAAACGAATGGCTCTGTTCGCAGTTACTGGCCG
CGTATGACATTCCCGTCGCACGTACGCAGATGGCGCAGTTTGAAGAGCAAAAAGTGTTGATCGTCGAGCGCTTCGACCGC
CGGTTATCGCGTGATAAACAGTGGTGGTTGCGCTTGCCGCAGGAGGATATGTGCCAGGCGCTCGGCGTGTCGCCGCTGCG
AAAATACCAGTCTGACGGCGGGCCGGGTATCGGCGATATCATGACTATCCTGAGTCGTTCAGAGCAGGCGCGGGCCGATC
GTGCCACTTTCTTCCGCGCGCAGATCGTTTTCTGGATCCTCGCCGCAACAGACGGCCACGCCAAGAACTTCAGCATCGCG
CATCTGCCCGGTAATCGTTATCACCTGACGCCGCTTTATGATGTGTTGTCCGCCTGGCCGGTGATTGGGCCGGGGAATAA
CCAGATTGCGTGGCAGAAATGTAAGCTCGCGATGGCGGTGCGGGGCAGCAGCAATTACTACCATCTGAGCCAGATCCGCC
GACGCCACTGGCTGCGCCAGGGCGAGCTTGCGGGGCTGTCGCACGCGCAGGTCACCGCGATGGTAGACGCGCTTATCGCC
GCGACACCCGATGTTATCGACCGCGTGGCCGCTGCGCTTCCGGCAGGCTTCCCCTTAGCGCTGGCGGAGCAGATTTTCGA
GGGCATGCGTCAGCAGTGCGCGCGTCTGGCGAACGCCTGA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10570.06 Da
• Isoelectric Point: 9.8278

>AT56192 WP_007669594.1 NZ_CP012265:c11240-10956 [Cronobacter condimenti 1330]
MTTVYPLKTLSQLRPLLVGFRKNQGLTQREVSERLGVTQQTYARLEANPASASIERLFRVFNVLGIEMTLSEMQKDPSSD
IAASDTSPARREAW

Nucleotide

• Length: 285 bp

>AT56192 NZ_CP012265:c11240-10956 [Cronobacter condimenti 1330]
ATGACTACCGTCTATCCACTGAAAACGCTCAGCCAGCTGCGCCCGCTGCTGGTGGGCTTTCGCAAAAACCAGGGACTGAC
GCAACGCGAAGTGTCCGAACGACTTGGGGTTACGCAGCAAACGTATGCCCGGCTTGAGGCCAACCCTGCCTCGGCAAGCA
TTGAACGTTTGTTCCGCGTATTTAACGTGCTCGGTATTGAGATGACGCTTAGCGAAATGCAGAAGGATCCCTCCTCTGAT
ATCGCTGCAAGTGACACCTCGCCCGCCCGTCGTGAGGCGTGGTGA

Structures

Toxin

• AlphaFold DB: K8A025