Detailed information of TA system TA056191

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3533252..3533915
• Replicon: chromosome
• Accession: NZ_CP012264
• Organism: Cronobacter condimenti 1330 strain LMG 26250

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: K7ZXC0
• Locus tag: AFK62_RS16100
• Protein ID: WP_007663800.1
• Coordinates: 3533252..3533668 (-)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: -
• Locus tag: AFK62_RS16105
• Protein ID: WP_032983876.1
• Coordinates: 3533649..3533915 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AFK62_RS16080	3529239..3530972	-	1734	WP_007663791.1	single-stranded-DNA-specific exonuclease RecJ	-
AFK62_RS16085	3530976..3531695	-	720	WP_007663793.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
AFK62_RS16090	3531718..3532614	-	897	WP_007663794.1	site-specific tyrosine recombinase XerD	-
AFK62_RS16095	3532716..3533237	+	522	WP_007663797.1	flavodoxin FldB	-
AFK62_RS16100	3533252..3533668	-	417	WP_007663800.1	protein YgfX	Toxin
AFK62_RS16105	3533649..3533915	-	267	WP_032983876.1	FAD assembly factor SdhE	Antitoxin
AFK62_RS16110	3534193..3535182	+	990	WP_007663804.1	tRNA-modifying protein YgfZ	-
AFK62_RS16115	3535332..3535985	-	654	WP_007663806.1	hemolysin III family protein	-
AFK62_RS16120	3536150..3536464	-	315	WP_007663808.1	N(4)-acetylcytidine aminohydrolase	-
AFK62_RS16125	3536634..3537368	+	735	WP_007663810.1	MurR/RpiR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 16388.33 Da
• Isoelectric Point: 11.6942

>T56191 WP_007663800.1 NZ_CP012264:c3533668-3533252 [Cronobacter condimenti 1330]
VVLWHSDLRVSWRSQWVSLLLHGAVAVIILLLPWPLRYLPVWMLLLSLVVFDCVRSQRRINAFQGEVSLTADYQLRWQGV
DWHICATPWMLRSGMMLRLRHPKTTRSHHVWLASDSMTAAEWRDLRRLLLQQPVRDTR

Nucleotide

• Length: 417 bp

>T56191 NZ_CP012264:c3533668-3533252 [Cronobacter condimenti 1330]
GTGGTCCTGTGGCACTCTGATCTTCGCGTCTCATGGCGCTCGCAGTGGGTATCGCTGCTGCTGCACGGTGCAGTAGCTGT
AATTATTTTGCTGCTCCCCTGGCCGTTGCGGTATTTACCCGTCTGGATGCTGTTGTTGTCTCTGGTGGTATTTGACTGCG
TGCGCAGTCAGCGGCGTATTAATGCGTTTCAGGGGGAAGTTAGCCTGACGGCGGATTACCAACTGCGCTGGCAGGGCGTC
GACTGGCACATATGCGCCACGCCCTGGATGTTGCGCAGTGGAATGATGTTGCGCCTGCGTCACCCTAAGACCACGCGCAG
CCATCATGTCTGGTTGGCGTCAGACAGTATGACGGCAGCGGAGTGGCGCGATTTACGCCGCCTTTTATTGCAGCAGCCGG
TACGAGATACCCGCTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10511.03 Da
• Isoelectric Point: 5.1454

>AT56191 WP_032983876.1 NZ_CP012264:c3533915-3533649 [Cronobacter condimenti 1330]
MDINNKARIHWACRRGMRELDISIMPFFEYDYDSLSEEDKRVFVRLLECDDPDLFNWLMNHGKPADAELARMVQLIQQRN
RERGPVAL

Nucleotide

• Length: 267 bp

>AT56191 NZ_CP012264:c3533915-3533649 [Cronobacter condimenti 1330]
ATGGACATAAACAATAAGGCCCGCATTCACTGGGCATGTCGCAGAGGTATGCGTGAGCTGGACATTTCAATCATGCCTTT
CTTTGAATACGACTATGACTCCCTGAGCGAAGAGGACAAACGCGTCTTTGTTCGCCTGCTGGAGTGTGACGATCCTGATT
TATTCAACTGGCTGATGAACCACGGCAAACCTGCTGATGCGGAACTGGCGCGGATGGTGCAATTGATTCAGCAACGGAAT
CGGGAACGTGGTCCTGTGGCACTCTGA

Structures

Toxin

• AlphaFold DB: K7ZXC0