Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-paaA/RelE(toxin)
Location 4041485..4041951 Replicon chromosome
Accession NZ_CP012257
Organism Cronobacter universalis NCTC 9529

Toxin (Protein)


Gene name relE Uniprot ID A0A376EY48
Locus tag AFK65_RS18685 Protein ID WP_007702902.1
Coordinates 4041676..4041951 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID A0A376F0P1
Locus tag AFK65_RS18680 Protein ID WP_007702899.1
Coordinates 4041485..4041676 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AFK65_RS18660 4037170..4038360 - 1191 WP_038858689.1 NAD(P)/FAD-dependent oxidoreductase -
AFK65_RS18665 4038590..4040092 + 1503 WP_038858684.1 inorganic phosphate transporter PitA -
AFK65_RS18670 4040143..4040478 - 336 WP_004388311.1 universal stress protein UspB -
AFK65_RS18675 4040873..4041310 + 438 WP_004388310.1 universal stress protein UspA -
AFK65_RS18680 4041485..4041676 + 192 WP_007702899.1 hypothetical protein Antitoxin
AFK65_RS18685 4041676..4041951 + 276 WP_007702902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AFK65_RS18690 4042014..4042766 - 753 WP_038858682.1 16S rRNA (guanine(1516)-N(2))-methyltransferase RsmJ -
AFK65_RS18695 4042775..4044817 - 2043 WP_038858681.1 oligopeptidase A -
AFK65_RS18700 4045010..4045852 + 843 WP_007702919.1 23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-90)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10367.96 Da        Isoelectric Point: 5.5520

>T56177 WP_007702902.1 NZ_CP012257:4041676-4041951 [Cronobacter universalis NCTC 9529]
MLPIQWTEEAKTDLFALISFVASDNPSAAQALLTRIEESILPAAHYPQMFREGRVPDTREIIAHPNYIVVYKVTAEYLLV
LSVLHARQQYP

Download         Length: 276 bp

>T56177 NZ_CP012257:4041676-4041951 [Cronobacter universalis NCTC 9529]
ATGCTCCCCATTCAATGGACTGAAGAAGCAAAAACGGATCTTTTTGCGCTTATTAGCTTTGTCGCCAGTGACAATCCTTC
CGCCGCGCAGGCGCTGTTAACGCGTATTGAAGAATCGATTTTACCCGCAGCGCACTATCCGCAGATGTTCCGCGAAGGCA
GAGTGCCGGATACGCGTGAAATCATTGCTCACCCGAATTACATCGTCGTTTATAAAGTCACTGCCGAGTACCTGCTGGTG
TTGAGCGTACTGCATGCCCGTCAGCAGTACCCGTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7279.22 Da        Isoelectric Point: 8.6993

>AT56177 WP_007702899.1 NZ_CP012257:4041485-4041676 [Cronobacter universalis NCTC 9529]
MPKHDSPGVSRFETHEQAEQYEQWFREKVEAAAASRQPITPHEDVMASARKIIESAKVRRKMA

Download         Length: 192 bp

>AT56177 NZ_CP012257:4041485-4041676 [Cronobacter universalis NCTC 9529]
ATGCCGAAACATGACTCGCCCGGTGTCTCCAGATTTGAGACCCATGAACAGGCGGAACAGTACGAGCAGTGGTTTCGTGA
AAAAGTGGAAGCCGCAGCGGCAAGCCGCCAACCCATTACGCCGCATGAAGATGTGATGGCAAGCGCGCGCAAGATCATTG
AGAGCGCAAAAGTGAGGAGAAAAATGGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A376EY48

Antitoxin

Source ID Structure
AlphaFold DB A0A376F0P1

References