Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/Doc-RelB |
| Location | 4005497..4006086 | Replicon | chromosome |
| Accession | NZ_CP012257 | ||
| Organism | Cronobacter universalis NCTC 9529 | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | A0A376F0G6 |
| Locus tag | AFK65_RS18500 | Protein ID | WP_007702851.1 |
| Coordinates | 4005497..4005865 (-) | Length | 123 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | A0A376EXY4 |
| Locus tag | AFK65_RS18505 | Protein ID | WP_007702854.1 |
| Coordinates | 4005865..4006086 (-) | Length | 74 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AFK65_RS18480 | 4001066..4002139 | - | 1074 | WP_007702817.1 | sn-glycerol-3-phosphate import ATP-binding protein UgpC | - |
| AFK65_RS18485 | 4002141..4002986 | - | 846 | WP_038858709.1 | sn-glycerol-3-phosphate ABC transporter permease UgpE | - |
| AFK65_RS18490 | 4002983..4003870 | - | 888 | WP_038858707.1 | sn-glycerol-3-phosphate ABC transporter permease UgpA | - |
| AFK65_RS18495 | 4004007..4005326 | - | 1320 | WP_032805014.1 | sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB | - |
| AFK65_RS18500 | 4005497..4005865 | - | 369 | WP_007702851.1 | type II toxin-antitoxin system death-on-curing family toxin | Toxin |
| AFK65_RS18505 | 4005865..4006086 | - | 222 | WP_007702854.1 | type II toxin-antitoxin system prevent-host-death family antitoxin | Antitoxin |
| AFK65_RS18510 | 4006226..4006939 | - | 714 | WP_007702856.1 | high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF | - |
| AFK65_RS18515 | 4006941..4007708 | - | 768 | WP_007778908.1 | high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG | - |
| AFK65_RS18520 | 4007705..4008985 | - | 1281 | WP_038858705.1 | high-affinity branched-chain amino acid ABC transporter permease LivM | - |
| AFK65_RS18525 | 4008982..4009908 | - | 927 | WP_004384851.1 | high-affinity branched-chain amino acid ABC transporter permease LivH | - |
| AFK65_RS18530 | 4009999..4010244 | - | 246 | WP_007702486.1 | hypothetical protein | - |
| AFK65_RS18535 | 4010665..4011057 | + | 393 | WP_007765109.1 | aspartate 1-decarboxylase autocleavage activator PanM | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 3995791..4008985 | 13194 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 123 a.a. Molecular weight: 13621.81 Da Isoelectric Point: 6.4831
>T56176 WP_007702851.1 NZ_CP012257:c4005865-4005497 [Cronobacter universalis NCTC 9529]
MTIHFISAEEIIRFHDRLLQVTPGVTGMPDPGRAEALMYRVLNKYEYEGVNDIWLLAAMHLLAVARGHIFNDDNKRTALF
ITLLFLKRNGIDVAANPGFVEMTVNAAAGRLSLEEIAAQLRA
MTIHFISAEEIIRFHDRLLQVTPGVTGMPDPGRAEALMYRVLNKYEYEGVNDIWLLAAMHLLAVARGHIFNDDNKRTALF
ITLLFLKRNGIDVAANPGFVEMTVNAAAGRLSLEEIAAQLRA
Download Length: 369 bp
>T56176 NZ_CP012257:c4005865-4005497 [Cronobacter universalis NCTC 9529]
ATGACGATTCATTTTATCTCAGCGGAAGAGATAATCCGTTTCCATGACCGTCTGTTGCAGGTCACGCCGGGGGTTACCGG
TATGCCTGATCCAGGGCGGGCCGAAGCGCTGATGTACCGCGTGCTCAACAAATATGAGTATGAGGGCGTTAATGATATCT
GGCTGCTGGCGGCCATGCATTTGCTGGCGGTTGCGCGCGGCCATATTTTTAACGACGATAACAAGCGTACGGCGCTATTC
ATCACGCTGTTGTTTCTTAAGCGAAACGGCATTGATGTGGCGGCCAATCCGGGTTTCGTTGAGATGACCGTCAACGCGGC
GGCAGGACGTCTGTCGCTGGAAGAGATTGCTGCTCAGCTTCGCGCTTAA
ATGACGATTCATTTTATCTCAGCGGAAGAGATAATCCGTTTCCATGACCGTCTGTTGCAGGTCACGCCGGGGGTTACCGG
TATGCCTGATCCAGGGCGGGCCGAAGCGCTGATGTACCGCGTGCTCAACAAATATGAGTATGAGGGCGTTAATGATATCT
GGCTGCTGGCGGCCATGCATTTGCTGGCGGTTGCGCGCGGCCATATTTTTAACGACGATAACAAGCGTACGGCGCTATTC
ATCACGCTGTTGTTTCTTAAGCGAAACGGCATTGATGTGGCGGCCAATCCGGGTTTCGTTGAGATGACCGTCAACGCGGC
GGCAGGACGTCTGTCGCTGGAAGAGATTGCTGCTCAGCTTCGCGCTTAA
Antitoxin
Download Length: 74 a.a. Molecular weight: 8052.06 Da Isoelectric Point: 5.6746
>AT56176 WP_007702854.1 NZ_CP012257:c4006086-4005865 [Cronobacter universalis NCTC 9529]
MRTMNYSEARQQLASALESAAAGTPVTITRRGHKSAVIISAEEFERYQAAKLDAEFAEIMAVHGNEIRELADK
MRTMNYSEARQQLASALESAAAGTPVTITRRGHKSAVIISAEEFERYQAAKLDAEFAEIMAVHGNEIRELADK
Download Length: 222 bp
>AT56176 NZ_CP012257:c4006086-4005865 [Cronobacter universalis NCTC 9529]
ATGCGTACCATGAACTATAGCGAAGCGAGACAGCAGCTGGCTTCTGCGCTGGAATCAGCGGCGGCCGGGACGCCAGTCAC
CATTACCCGCCGTGGCCATAAATCAGCGGTGATCATTAGCGCAGAAGAATTCGAGCGTTATCAGGCCGCGAAGCTGGATG
CGGAATTTGCGGAGATCATGGCTGTGCACGGTAATGAAATCAGGGAGCTTGCGGATAAATAA
ATGCGTACCATGAACTATAGCGAAGCGAGACAGCAGCTGGCTTCTGCGCTGGAATCAGCGGCGGCCGGGACGCCAGTCAC
CATTACCCGCCGTGGCCATAAATCAGCGGTGATCATTAGCGCAGAAGAATTCGAGCGTTATCAGGCCGCGAAGCTGGATG
CGGAATTTGCGGAGATCATGGCTGTGCACGGTAATGAAATCAGGGAGCTTGCGGATAAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A376F0G6 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A376EXY4 |