Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 3848202..3848787 Replicon chromosome
Accession NZ_CP012257
Organism Cronobacter universalis NCTC 9529

Toxin (Protein)


Gene name PumA Uniprot ID A0A376EZK7
Locus tag AFK65_RS17710 Protein ID WP_032804980.1
Coordinates 3848202..3848507 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A376EX34
Locus tag AFK65_RS17715 Protein ID WP_007702390.1
Coordinates 3848512..3848787 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3840594..3848787 8193


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(4-93)

Antitoxin

Uncharacterized protein HI1420

(2-89)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11574.55 Da        Isoelectric Point: 10.3395

>T56175 WP_032804980.1 NZ_CP012257:3848202-3848507 [Cronobacter universalis NCTC 9529]
MKHIFQTEVFRRWQASLKDQRVKTMIAARLFRLANGLPGDVKPVGAGISELRIHYGAGYRIYFKQHGDVIVILLCGGDKH
TQDKDILLAKMLADLPENQWR

Download         Length: 306 bp

>T56175 NZ_CP012257:3848202-3848507 [Cronobacter universalis NCTC 9529]
ATGAAGCATATTTTTCAAACTGAAGTATTCCGCCGTTGGCAAGCCAGTCTGAAAGACCAGCGGGTAAAAACGATGATTGC
CGCGCGGCTTTTTCGGCTGGCTAATGGTTTGCCTGGTGATGTTAAGCCCGTCGGCGCAGGCATCAGCGAGCTGCGTATTC
ACTACGGCGCGGGATACCGGATTTATTTCAAACAACACGGCGACGTGATTGTCATTTTGCTTTGTGGTGGTGATAAGCAC
ACGCAGGATAAAGACATTCTTCTTGCGAAAATGCTGGCTGACCTGCCAGAGAACCAGTGGAGATAA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 9655.14 Da        Isoelectric Point: 6.4609

>AT56175 WP_007702390.1 NZ_CP012257:3848512-3848787 [Cronobacter universalis NCTC 9529]
MKLTEYDPAAALIDDEEIAFFMADALETGDAGHIAKALGIVARAKGMSHIASQTGLSREQLYRSFSDKGNPTLKTTLAVM
KALGLGLTIKS

Download         Length: 276 bp

>AT56175 NZ_CP012257:3848512-3848787 [Cronobacter universalis NCTC 9529]
ATGAAGCTGACCGAATACGATCCCGCTGCGGCGCTGATTGATGATGAGGAGATCGCCTTCTTTATGGCGGACGCGCTCGA
AACTGGCGACGCCGGACATATTGCAAAGGCGCTGGGCATCGTCGCGCGCGCTAAAGGCATGTCGCATATCGCCTCTCAGA
CAGGGTTGTCGCGTGAACAGCTGTACCGTTCTTTCAGTGATAAAGGCAACCCAACGCTTAAAACCACGCTGGCAGTGATG
AAAGCGCTGGGTCTCGGTTTAACGATTAAATCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A376EZK7

Antitoxin

Source ID Structure
AlphaFold DB A0A376EX34

References