Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3459230..3459893 Replicon chromosome
Accession NZ_CP012257
Organism Cronobacter universalis NCTC 9529

Toxin (Protein)


Gene name cptA Uniprot ID A0A376ETR5
Locus tag AFK65_RS15890 Protein ID WP_038856373.1
Coordinates 3459230..3459646 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A376EUF0
Locus tag AFK65_RS15895 Protein ID WP_007700751.1
Coordinates 3459627..3459893 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AFK65_RS15870 3455215..3456948 - 1734 WP_007700758.1 single-stranded-DNA-specific exonuclease RecJ -
AFK65_RS15875 3456952..3457671 - 720 WP_007700755.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
AFK65_RS15880 3457694..3458590 - 897 WP_007700754.1 site-specific tyrosine recombinase XerD -
AFK65_RS15885 3458692..3459213 + 522 WP_007700753.1 flavodoxin FldB -
AFK65_RS15890 3459230..3459646 - 417 WP_038856373.1 protein YgfX Toxin
AFK65_RS15895 3459627..3459893 - 267 WP_007700751.1 FAD assembly factor SdhE Antitoxin
AFK65_RS15900 3460171..3461160 + 990 WP_007700748.1 tRNA-modifying protein YgfZ -
AFK65_RS15905 3461269..3461922 - 654 WP_007700745.1 hemolysin III family protein -
AFK65_RS15910 3462065..3462379 - 315 WP_032804825.1 N(4)-acetylcytidine aminohydrolase -
AFK65_RS15915 3462568..3463296 + 729 WP_032805608.1 MurR/RpiR family transcriptional regulator -
AFK65_RS15920 3463448..3464881 + 1434 WP_007700737.1 6-phospho-beta-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 16371.30 Da        Isoelectric Point: 11.6942

>T56173 WP_038856373.1 NZ_CP012257:c3459646-3459230 [Cronobacter universalis NCTC 9529]
VVLWHSDLRVSWRSQWVSLLLHGAVAVIILLLPWPLRYLPVWMLLLSLVVFDCVRSQRRINAFQGEVSLTADYQLRWQGV
DWHICATPWMLRSGMMLRLRHPKTTRRHHVWLASDSMTAAEWRDLRRLLLQQPVGDNR

Download         Length: 417 bp

>T56173 NZ_CP012257:c3459646-3459230 [Cronobacter universalis NCTC 9529]
GTGGTCCTGTGGCACTCTGATCTTCGCGTCTCATGGCGCTCGCAGTGGGTATCGCTGCTGCTGCACGGCGCCGTGGCCGT
TATTATTTTACTGCTCCCGTGGCCGTTGCGGTATCTGCCGGTCTGGATGCTGTTGCTGTCTCTGGTGGTGTTTGACTGCG
TACGCAGTCAGCGGCGTATCAATGCGTTTCAGGGAGAGGTGAGCCTGACGGCCGATTACCAGCTGCGCTGGCAGGGCGTC
GACTGGCATATTTGCGCCACGCCCTGGATGTTGCGCAGCGGAATGATGCTGCGGCTGCGTCATCCGAAAACGACGCGCCG
CCATCATGTGTGGCTGGCGTCAGACAGCATGACGGCGGCGGAGTGGCGCGATTTACGTCGGCTGTTGCTGCAACAGCCCG
TGGGCGACAACCGCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10353.86 Da        Isoelectric Point: 5.0989

>AT56173 WP_007700751.1 NZ_CP012257:c3459893-3459627 [Cronobacter universalis NCTC 9529]
MDINNKARIHWACRRGMRELDISIMPFFEYDYDSLSDEDKRVFVRLLECDDPDLFNWLMNHGKPADAELARMVALIQQRN
QARGPVAL

Download         Length: 267 bp

>AT56173 NZ_CP012257:c3459893-3459627 [Cronobacter universalis NCTC 9529]
ATGGATATTAATAATAAAGCCCGTATTCACTGGGCATGTCGCAGAGGTATGCGCGAACTGGATATTTCCATCATGCCTTT
CTTTGAGTATGACTACGACTCCCTGAGCGATGAAGACAAACGCGTTTTTGTCCGCCTGCTGGAGTGTGACGATCCTGATT
TATTCAACTGGCTGATGAATCATGGCAAACCTGCCGATGCGGAACTGGCGCGAATGGTGGCATTGATCCAGCAGCGGAAT
CAGGCTCGTGGTCCTGTGGCACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A376ETR5

Antitoxin

Source ID Structure
AlphaFold DB A0A376EUF0

References