Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1149360..1149979 Replicon chromosome
Accession NZ_CP012257
Organism Cronobacter universalis NCTC 9529

Toxin (Protein)


Gene name Hha Uniprot ID A0A376E575
Locus tag AFK65_RS05220 Protein ID WP_007706154.1
Coordinates 1149360..1149578 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A376E4G6
Locus tag AFK65_RS05225 Protein ID WP_007706157.1
Coordinates 1149605..1149979 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AFK65_RS05200 1145486..1147387 + 1902 WP_038857804.1 methyl-accepting chemotaxis protein -
AFK65_RS05205 1147528..1147788 + 261 WP_004386912.1 type B 50S ribosomal protein L31 -
AFK65_RS20730 1147792..1147932 + 141 WP_004386911.1 type B 50S ribosomal protein L36 -
AFK65_RS05210 1147964..1148473 - 510 WP_007706149.1 YlaC family protein -
AFK65_RS05215 1148594..1149145 - 552 WP_007706151.1 maltose O-acetyltransferase -
AFK65_RS05220 1149360..1149578 - 219 WP_007706154.1 hemolysin expression modulator Hha Toxin
AFK65_RS05225 1149605..1149979 - 375 WP_007706157.1 Hha toxicity modulator TomB Antitoxin
AFK65_RS05230 1150443..1153592 - 3150 WP_007706160.1 multidrug efflux RND transporter permease subunit -
AFK65_RS05235 1153614..1154819 - 1206 WP_007706161.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8626.07 Da        Isoelectric Point: 9.4828

>T56160 WP_007706154.1 NZ_CP012257:c1149578-1149360 [Cronobacter universalis NCTC 9529]
MTTKPLTKIDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFVR

Download         Length: 219 bp

>T56160 NZ_CP012257:c1149578-1149360 [Cronobacter universalis NCTC 9529]
ATGACGACCAAACCATTAACCAAAATCGATTATTTAATGCGACTGAGACGCTGTCAGACAATTGACACGCTTGAGCGCGT
TATTGAAAAAAATAAATATGAATTATCCGACAATGAACTGGCGGTATTTTATTCAGCCGCAGATCATCGCCTGGCTGAAC
TGACCATGAATAAGCTTTACGATAAAATCCCGACGTCTGTGTGGAAATTTGTTCGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14387.10 Da        Isoelectric Point: 4.7168

>AT56160 WP_007706157.1 NZ_CP012257:c1149979-1149605 [Cronobacter universalis NCTC 9529]
MDEYSPKRHDIAQLKFLCESLYHDCLATLGENQHGWVNDPTSAVNLQLNDLIEHIASFGLNYKIKHEDDTALIEQLDEYL
DDTFMLFSNYGINAQDLQKWRKSGNRLFRCFINASKENPVSLSF

Download         Length: 375 bp

>AT56160 NZ_CP012257:c1149979-1149605 [Cronobacter universalis NCTC 9529]
ATGGACGAATACTCACCAAAACGGCATGATATAGCGCAGCTTAAATTTCTGTGTGAAAGCCTGTATCATGATTGCCTCGC
CACGCTAGGCGAAAACCAGCATGGCTGGGTTAACGACCCCACATCCGCCGTTAACCTGCAACTCAACGACTTGATTGAGC
ATATTGCCAGCTTCGGTCTTAATTATAAAATTAAGCATGAAGATGATACCGCTCTCATTGAACAATTAGATGAATATCTG
GACGATACCTTTATGCTTTTCAGCAATTACGGTATCAATGCGCAAGATTTGCAAAAATGGCGCAAGTCCGGAAACAGGCT
TTTCCGGTGTTTCATTAACGCCAGCAAAGAAAACCCTGTGAGCTTGTCTTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A376E575

Antitoxin

Source ID Structure
AlphaFold DB A0A376E4G6

References