Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 413006..413669 Replicon chromosome
Accession NZ_CP012253
Organism Cronobacter sakazakii strain NCTC 8155

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag AFK64_RS02020 Protein ID WP_004385675.1
Coordinates 413253..413669 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID -
Locus tag AFK64_RS02015 Protein ID WP_004385674.1
Coordinates 413006..413272 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AFK64_RS01990 408034..409467 - 1434 WP_004385669.1 6-phospho-beta-glucosidase -
AFK64_RS01995 409619..410347 - 729 WP_004385670.1 MurR/RpiR family transcriptional regulator -
AFK64_RS02000 410524..410838 + 315 WP_004385671.1 N(4)-acetylcytidine aminohydrolase -
AFK64_RS02005 410981..411634 + 654 WP_004385672.1 hemolysin III family protein -
AFK64_RS02010 411739..412728 - 990 WP_004385673.1 tRNA-modifying protein YgfZ -
AFK64_RS02015 413006..413272 + 267 WP_004385674.1 FAD assembly factor SdhE Antitoxin
AFK64_RS02020 413253..413669 + 417 WP_004385675.1 protein YgfX Toxin
AFK64_RS02025 413683..414204 - 522 WP_004385676.1 flavodoxin FldB -
AFK64_RS02030 414306..415202 + 897 WP_004385677.1 site-specific tyrosine recombinase XerD -
AFK64_RS02035 415225..415944 + 720 WP_004385678.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
AFK64_RS02040 415948..417681 + 1734 WP_004385679.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 16446.46 Da        Isoelectric Point: 11.4887

>T56141 WP_004385675.1 NZ_CP012253:413253-413669 [Cronobacter sakazakii]
VVLWHSDLRVSWRSQWLSLLLHGAVAVIILLLPWPLRYLPVWMLLLSLVVFDCVRSQRRINAFQGEVSLTADYQLRWQGV
DWQICATPWMLRSGMMLRLRHPKTTRRHHVWLAADSMTEAEWRDLRRLLLQQPIGDKR

Download         Length: 417 bp

>T56141 NZ_CP012253:413253-413669 [Cronobacter sakazakii]
GTGGTCCTGTGGCACTCTGATCTTCGCGTTTCATGGCGCTCGCAGTGGCTATCGCTGCTGCTGCACGGCGCCGTGGCCGT
TATTATTTTGCTGCTCCCCTGGCCGCTGCGGTATCTGCCCGTGTGGATGCTGTTGCTGTCTCTGGTGGTGTTTGACTGCG
TGCGTAGCCAACGGCGTATCAATGCGTTTCAGGGCGAGGTCAGCCTGACGGCTGATTATCAGCTACGCTGGCAGGGCGTT
GACTGGCAGATTTGCGCCACGCCCTGGATGTTGCGCAGCGGAATGATGCTGCGGCTGCGTCATCCGAAAACGACGCGCCG
CCATCATGTCTGGCTGGCGGCGGATAGCATGACGGAAGCGGAGTGGCGCGATTTGCGTCGCCTTCTGTTGCAACAGCCCA
TAGGCGACAAACGCTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10358.84 Da        Isoelectric Point: 4.6289

>AT56141 WP_004385674.1 NZ_CP012253:413006-413272 [Cronobacter sakazakii]
MDINNKARIHWACRRGMRELDISIMPFFEYDYDSLSDEDKCVFVRLLECDDPDLFNWLMNHGKPADAELARMVELIQQRN
QARGPVAL

Download         Length: 267 bp

>AT56141 NZ_CP012253:413006-413272 [Cronobacter sakazakii]
ATGGATATTAATAATAAAGCCCGTATTCATTGGGCATGTCGCAGAGGTATGCGCGAGCTGGATATTTCCATCATGCCTTT
CTTTGAATATGACTATGACTCCCTGAGCGACGAAGACAAATGCGTTTTTGTCCGCCTGCTGGAGTGTGACGATCCTGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCAGCTGATGCGGAGCTGGCGCGAATGGTGGAATTAATCCAGCAGCGGAAT
CAGGCACGTGGTCCTGTGGCACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References