Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 44348..45018 Replicon chromosome
Accession NZ_CP012253
Organism Cronobacter sakazakii strain NCTC 8155

Toxin (Protein)


Gene name tad Uniprot ID -
Locus tag AFK64_RS00280 Protein ID WP_007852532.1
Coordinates 44348..44698 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID -
Locus tag AFK64_RS00285 Protein ID WP_015386308.1
Coordinates 44695..45018 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AFK64_RS00265 41898..43529 + 1632 WP_007852537.1 Na/Pi cotransporter family protein -
AFK64_RS00270 43546..43821 - 276 WP_007852536.1 putative addiction module antidote protein -
AFK64_RS00275 43826..44131 - 306 WP_014727945.1 type II toxin-antitoxin system RelE/ParE family toxin -
AFK64_RS00280 44348..44698 + 351 WP_007852532.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AFK64_RS00285 44695..45018 + 324 WP_015386308.1 helix-turn-helix domain-containing protein Antitoxin
AFK64_RS00290 45045..45317 - 273 WP_004387517.1 DUF3811 domain-containing protein -
AFK64_RS00295 45408..46343 - 936 WP_004387518.1 ketopantoate/pantoate/pantothenate transporter PanS -
AFK64_RS00300 46505..48097 - 1593 WP_004387519.1 RNA repair transcriptional activator RtcR -
AFK64_RS00305 48573..49706 + 1134 WP_004387521.1 slipin family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-90)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12977.99 Da        Isoelectric Point: 10.2932

>T56139 WP_007852532.1 NZ_CP012253:44348-44698 [Cronobacter sakazakii]
MIKPLFWVGQARKDLQALPEDVQDLFGYALYLAQQGRRHPQARPLKGFGGAGVLEVVEDYQGNAFRAVYTVRLGEAIYVL
HVFQKKSSSGIATPRPEMEKIEQRLKAAQRHAGGLK

Download         Length: 351 bp

>T56139 NZ_CP012253:44348-44698 [Cronobacter sakazakii]
ATGATAAAACCGTTGTTTTGGGTCGGGCAGGCCAGAAAAGATCTTCAGGCGCTGCCGGAGGATGTACAGGATCTTTTTGG
CTATGCGCTTTATCTGGCGCAGCAGGGCAGACGCCATCCGCAGGCCAGGCCGCTTAAAGGTTTTGGCGGCGCGGGTGTGC
TTGAGGTCGTGGAGGATTATCAGGGGAATGCCTTTCGGGCGGTCTATACCGTTCGTCTGGGCGAGGCGATTTATGTCCTG
CATGTATTCCAGAAAAAATCCTCTTCCGGGATTGCCACGCCCCGCCCGGAGATGGAAAAAATTGAACAGCGACTTAAAGC
CGCGCAACGCCACGCCGGAGGGCTGAAATGA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11804.88 Da        Isoelectric Point: 6.9798

>AT56139 WP_015386308.1 NZ_CP012253:44695-45018 [Cronobacter sakazakii]
MTADIERSNGNVYDDLGLIDAEEMELKAQLAMAISDILKARGLTQQEAARLLGMTQPKLSLLLRGQFRGISETKMMACLM
LLGRDISIVVGEAQHARGKMRLIYQPA

Download         Length: 324 bp

>AT56139 NZ_CP012253:44695-45018 [Cronobacter sakazakii]
ATGACAGCAGACATTGAACGCAGTAACGGAAATGTGTATGACGATCTCGGGCTTATCGATGCCGAAGAGATGGAGCTAAA
AGCGCAGCTCGCTATGGCGATTAGCGACATTCTTAAAGCGCGCGGTTTAACCCAACAGGAGGCGGCCCGTCTTCTGGGAA
TGACCCAGCCCAAACTCTCTTTATTACTTCGCGGCCAGTTTCGCGGGATCAGCGAAACGAAAATGATGGCCTGCCTGATG
CTCCTCGGGCGGGATATCAGCATCGTCGTGGGCGAGGCACAGCATGCGCGCGGAAAAATGCGCCTGATCTATCAGCCAGC
CTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References