Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2012457..2013114 Replicon chromosome
Accession NZ_CP012252
Organism Klebsiella quasipneumoniae strain HKUOPLA

Toxin (Protein)


Gene name cptA Uniprot ID A0A2A5MNX1
Locus tag AKG92_RS09410 Protein ID WP_004205323.1
Coordinates 2012457..2012867 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag AKG92_RS09415 Protein ID WP_002916312.1
Coordinates 2012848..2013114 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AKG92_RS09390 2008457..2010190 - 1734 WP_004205327.1 single-stranded-DNA-specific exonuclease RecJ -
AKG92_RS09395 2010196..2010909 - 714 WP_004205326.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
AKG92_RS09400 2010932..2011828 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
AKG92_RS09405 2011929..2012450 + 522 WP_004205324.1 flavodoxin FldB -
AKG92_RS09410 2012457..2012867 - 411 WP_004205323.1 protein YgfX Toxin
AKG92_RS09415 2012848..2013114 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
AKG92_RS09420 2013360..2014343 + 984 WP_017899798.1 tRNA-modifying protein YgfZ -
AKG92_RS09425 2014494..2015153 - 660 WP_053809968.1 hemolysin III family protein -
AKG92_RS09430 2015316..2015627 - 312 WP_004205318.1 N(4)-acetylcytidine aminohydrolase -
AKG92_RS09435 2015677..2016405 + 729 WP_004205316.1 MurR/RpiR family transcriptional regulator -
AKG92_RS09440 2016524..2017957 + 1434 WP_049004121.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16035.83 Da        Isoelectric Point: 11.4778

>T56136 WP_004205323.1 NZ_CP012252:c2012867-2012457 [Klebsiella quasipneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
DWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T56136 NZ_CP012252:c2012867-2012457 [Klebsiella quasipneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCTCTGCTGCTCCACGGCGTTGTGGCGGC
GCTGGTGCTGCTGGTTCCCTGGCCGTTAAGCTACACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTTGACTGTG
TGCGCAGCCAGCGACGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGGCTGCGCTGGCAAAACGCC
GACTGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT56136 WP_002916312.1 NZ_CP012252:c2013114-2012848 [Klebsiella quasipneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT56136 NZ_CP012252:c2013114-2012848 [Klebsiella quasipneumoniae]
ATGGACATTAACAATAAAGCTCGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TATTCAACTGGCTGATGAACCATGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A5MNX1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References