Detailed information of TA system TA056126

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): FicTA/Fic(toxin)
• Location: 1368789..1369707
• Replicon: chromosome
• Accession: NZ_CP012221
• Organism: Campylobacter jejuni strain CJ018CCUA

Toxin (Protein)

• Gene name: Fic
• Uniprot ID: -
• Locus tag: AEI23_RS07370
• Protein ID: WP_085782102.1
• Coordinates: 1369024..1369707 (+)
• Length: 228 a.a.

Antitoxin (Protein)

• Gene name: Fti
• Uniprot ID: A0A3Z9GMV3
• Locus tag: AEI23_RS07365
• Protein ID: WP_002907823.1
• Coordinates: 1368789..1369031 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AEI23_RS07350	1363928..1366141	+	2214	WP_052796197.1	DUF1738 domain-containing protein	-
AEI23_RS07355	1366138..1367961	+	1824	WP_052796196.1	type IV secretory system conjugative DNA transfer family protein	-
AEI23_RS07360	1367978..1368697	+	720	WP_052796195.1	conjugal transfer protein TraL	-
AEI23_RS07365	1368789..1369031	+	243	WP_002907823.1	hypothetical protein	Antitoxin
AEI23_RS07370	1369024..1369707	+	684	WP_085782102.1	Fic family protein	Toxin
AEI23_RS07375	1369712..1370179	+	468	WP_002907837.1	signal peptidase I	-
AEI23_RS07380	1370268..1370915	+	648	WP_115766855.1	DNA/RNA non-specific endonuclease	-
AEI23_RS07385	1370948..1371343	+	396	WP_002907857.1	conjugal transfer protein TraM	-
AEI23_RS07390	1371424..1372110	+	687	WP_002907859.1	AAA family ATPase	-
AEI23_RS07395	1372113..1372337	+	225	WP_052816869.1	hypothetical protein	-
AEI23_RS07400	1372717..1374141	-	1425	Protein_1434	motility associated factor glycosyltransferase family protein	-
AEI23_RS07405	1374143..1374397	-	255	Protein_1435	motility associated factor glycosyltransferase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Fido domain (60-169)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 228 a.a.
• Molecular weight: 26078.32 Da
• Isoelectric Point: 10.1719

>T56126 WP_085782102.1 NZ_CP012221:1369024-1369707 [Campylobacter jejuni]
MIDKVLKFLDDGIPKNDFDRQLLASNLVGATNLIELNKREREITLKKQLKLQLNPIKGNFDYQHLKDIHKALFEDVYTWA
GQDRMQMGLKEKFAKYAPNGAIINFVPGKELDKYSKIIFDELAKNNYLKNSKDLNHFAKNLAKFMGEINALHPFREGNGR
TQRIFLNELAKNAGYKLDLNLIPKDKMIMASVEASQLKLGKLEAVIKSNLKNFRQNLDLEQNKGISL

Nucleotide

• Length: 684 bp

>T56126 NZ_CP012221:1369024-1369707 [Campylobacter jejuni]
ATGATTGATAAAGTTTTGAAATTTTTAGATGATGGTATTCCTAAAAATGATTTTGACAGACAACTTTTAGCTTCTAATTT
AGTAGGCGCAACAAATTTAATAGAGTTAAATAAACGAGAAAGAGAAATTACATTAAAAAAACAATTAAAACTACAACTCA
ATCCCATTAAAGGCAATTTCGATTATCAGCATTTAAAAGATATACATAAAGCACTTTTTGAAGATGTTTATACTTGGGCA
GGACAAGATAGAATGCAAATGGGACTAAAAGAAAAATTTGCAAAATATGCACCCAATGGAGCAATTATTAATTTTGTTCC
TGGAAAAGAGTTAGATAAATACTCTAAAATAATTTTTGATGAACTTGCAAAAAATAACTATCTAAAAAACTCCAAAGATC
TAAATCATTTTGCAAAAAATTTAGCAAAATTTATGGGCGAAATCAATGCTTTACACCCTTTTAGAGAAGGTAACGGCAGA
ACTCAAAGAATATTTTTAAACGAGTTGGCTAAAAATGCAGGTTATAAACTTGATTTAAATTTAATACCAAAAGATAAAAT
GATAATGGCATCTGTAGAAGCTTCACAATTGAAATTAGGAAAACTTGAAGCCGTGATTAAAAGCAATCTAAAAAACTTTA
GACAAAACTTAGATTTAGAGCAAAATAAAGGAATATCATTGTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9276.49 Da
• Isoelectric Point: 4.3697

>AT56126 WP_002907823.1 NZ_CP012221:1368789-1369031 [Campylobacter jejuni]
MQKQYPEVHSLEESLAILKKYKDDLTKEQYEGIKSVICGHAIEDMFANEKDVIDMIKIAKDEANADEIIAEYKREWGVND

Nucleotide

• Length: 243 bp

>AT56126 NZ_CP012221:1368789-1369031 [Campylobacter jejuni]
ATGCAAAAACAATATCCCGAAGTGCATAGCTTAGAAGAAAGTCTTGCGATACTTAAAAAATATAAAGATGATTTAACTAA
AGAGCAATATGAAGGTATTAAATCTGTTATTTGCGGACACGCTATTGAAGATATGTTTGCAAATGAAAAAGATGTTATCG
ATATGATAAAAATTGCAAAAGATGAAGCAAATGCCGATGAAATAATCGCCGAATATAAAAGAGAATGGGGAGTAAATGAT
TGA

Structures

Antitoxin

• AlphaFold DB: A0A3Z9GMV3