Detailed information of TA system TA056125

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): virAT/YafQ(toxin)
• Location: 1670996..1671539
• Replicon: chromosome
• Accession: NZ_CP012215
• Organism: Campylobacter jejuni strain CJ518CC45

Toxin (Protein)

• Gene name: virT
• Uniprot ID: -
• Locus tag: AEI13_RS08780
• Protein ID: WP_053868684.1
• Coordinates: 1670996..1671265 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: virA
• Uniprot ID: A0A5T1CFM5
• Locus tag: AEI13_RS08785
• Protein ID: WP_053868685.1
• Coordinates: 1671255..1671539 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AEI13_RS08760 (AEI13_08790)	1667444..1667686	-	243	WP_011117593.1	hypothetical protein	-
AEI13_RS08765 (AEI13_08795)	1667686..1667991	-	306	WP_014517469.1	hypothetical protein	-
AEI13_RS08770 (AEI13_08800)	1668865..1670448	+	1584	WP_260535762.1	relaxase/mobilization nuclease domain-containing protein	-
AEI13_RS08775 (AEI13_08805)	1670571..1670882	-	312	Protein_1710	hypothetical protein	-
AEI13_RS08780 (AEI13_08810)	1670996..1671265	-	270	WP_053868684.1	type II toxin-antitoxin system YafQ family toxin	Toxin
AEI13_RS08785 (AEI13_08815)	1671255..1671539	-	285	WP_053868685.1	hypothetical protein	Antitoxin
AEI13_RS08790 (AEI13_08820)	1671763..1672125	-	363	WP_025443372.1	hypothetical protein	-
AEI13_RS08795 (AEI13_08825)	1672298..1672600	-	303	WP_053868731.1	hypothetical protein	-
AEI13_RS08800 (AEI13_08830)	1672600..1673031	-	432	WP_025443374.1	hypothetical protein	-
AEI13_RS08805 (AEI13_08835)	1673028..1673444	-	417	WP_115784918.1	hypothetical protein	-
AEI13_RS08810 (AEI13_08845)	1673980..1674198	-	219	WP_025443376.1	hypothetical protein	-
AEI13_RS08815 (AEI13_08850)	1674210..1674515	-	306	WP_025443377.1	hypothetical protein	-
AEI13_RS08820 (AEI13_08855)	1674529..1674873	-	345	WP_011117579.1	hypothetical protein	-
AEI13_RS08825 (AEI13_08860)	1675334..1675759	-	426	WP_052835067.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-89)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10616.28 Da
• Isoelectric Point: 9.5064

>T56125 WP_053868684.1 NZ_CP012215:c1671265-1670996 [Campylobacter jejuni]
MPYKITLSKKYKQKYKKANTKDRILIDEVVEKLSNDETLEEKYKDHALKGNYIGFRECHIKPDLLLVYRKNNDILELYLA
NLGNHNNIF

Nucleotide

• Length: 270 bp

>T56125 NZ_CP012215:c1671265-1670996 [Campylobacter jejuni]
ATGCCTTATAAAATTACATTATCTAAAAAATACAAGCAAAAATATAAAAAAGCAAACACAAAAGACAGAATATTGATTGA
TGAAGTTGTTGAAAAATTATCTAATGATGAAACATTAGAAGAAAAATACAAAGACCACGCATTAAAAGGAAATTATATTG
GTTTTAGAGAATGCCACATTAAACCTGATTTGTTATTAGTCTATCGCAAAAATAATGATATTTTAGAATTATATTTGGCT
AATTTAGGAAATCACAATAATATTTTTTAG

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 11186.76 Da
• Isoelectric Point: 10.0400

>AT56125 WP_053868685.1 NZ_CP012215:c1671539-1671255 [Campylobacter jejuni]
MFDYSKYENASKKQLIHALTLAEKRAEKLNSQLKENNEFFKFLQKKLKKSFNAKKTKKAEQRRPELDEAIEDYKNGNVET
YANFEEYKKAMNAL

Nucleotide

• Length: 285 bp

>AT56125 NZ_CP012215:c1671539-1671255 [Campylobacter jejuni]
ATGTTTGATTATTCTAAATATGAAAATGCTAGCAAAAAACAATTAATACACGCTTTGACTTTAGCAGAAAAAAGGGCGGA
GAAACTAAACTCGCAATTAAAAGAGAATAACGAATTTTTTAAATTTTTACAAAAAAAGTTAAAAAAATCTTTTAACGCCA
AAAAAACAAAAAAAGCAGAGCAAAGAAGACCTGAATTAGATGAAGCGATTGAAGATTATAAAAATGGAAATGTAGAAACC
TATGCTAATTTTGAAGAATATAAAAAGGCTATGAATGCCTTATAA

Structures

Antitoxin

• AlphaFold DB: A0A5T1CFM5