Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 96459..97056 Replicon chromosome
Accession NZ_CP012200
Organism Thermococcus sp. 2319x1

Toxin (Protein)


Gene name vapC Uniprot ID A0A0U3QV58
Locus tag ADU37_RS00475 Protein ID WP_058945791.1
Coordinates 96459..96848 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0U3SVW6
Locus tag ADU37_RS00480 Protein ID WP_058945792.1
Coordinates 96835..97056 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ADU37_RS00450 (ADU37_CDS00880) 92471..93136 + 666 WP_058945786.1 DUF4097 family beta strand repeat-containing protein -
ADU37_RS00455 (ADU37_CDS00890) 93123..93704 - 582 WP_082663067.1 CPBP family archaeomyxosortase MrtA -
ADU37_RS00460 (ADU37_CDS00900) 93744..94607 - 864 WP_058945788.1 peptidylprolyl isomerase -
ADU37_RS00465 (ADU37_CDS00910) 94728..96158 + 1431 WP_203226271.1 cysteine--tRNA ligase -
ADU37_RS00470 (ADU37_CDS00920) 96159..96413 - 255 WP_058945790.1 hypothetical protein -
ADU37_RS00475 (ADU37_CDS00930) 96459..96848 - 390 WP_058945791.1 type II toxin-antitoxin system VapC family toxin Toxin
ADU37_RS00480 (ADU37_CDS00940) 96835..97056 - 222 WP_058945792.1 hypothetical protein Antitoxin
ADU37_RS00485 (ADU37_CDS00950) 97214..98557 + 1344 WP_082662996.1 M20/M25/M40 family metallo-hydrolase -
ADU37_RS00495 (ADU37_CDS00970) 99042..99248 + 207 WP_058945795.1 hypothetical protein -
ADU37_RS00500 (ADU37_CDS00980) 99459..99692 + 234 WP_058945796.1 hypothetical protein -
ADU37_RS11180 (ADU37_CDS00990) 100078..100263 + 186 WP_144433157.1 hypothetical protein -
ADU37_RS00515 (ADU37_CDS01000) 100268..100825 + 558 WP_058945799.1 hypothetical protein -
ADU37_RS00520 (ADU37_CDS01010) 100846..101229 - 384 Protein_96 hypothetical protein -
ADU37_RS00525 (ADU37_CDS01020) 101225..101872 + 648 WP_058945801.1 phosphoribosyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-120)

Antitoxin

Putative antitoxin VapB3-like

(1-73)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14811.24 Da        Isoelectric Point: 4.7309

>T56116 WP_058945791.1 NZ_CP012200:c96848-96459 [Thermococcus sp. 2319x1]
VIVIDASALAKVILQEENWESIPLTEKTATLDYALVEALNAIWKAVIQKRLDEEDAKDRTEALKYLAKSLLLFEAKNYFE
RALEIALKEKITVYDALYIALAEELKAEFYTPDVKQFEAAKKYVRVKLI

Download         Length: 390 bp

>T56116 NZ_CP012200:c96848-96459 [Thermococcus sp. 2319x1]
GTGATAGTAATTGATGCATCTGCTCTCGCTAAAGTTATCCTTCAAGAAGAGAACTGGGAAAGTATCCCACTAACGGAAAA
AACTGCAACGCTGGATTACGCTCTCGTTGAAGCATTAAACGCTATTTGGAAGGCTGTTATCCAAAAACGGCTAGATGAAG
AAGACGCAAAAGACAGAACTGAAGCACTGAAGTATCTCGCCAAAAGCCTGTTGCTCTTCGAAGCCAAGAATTACTTTGAG
CGTGCTTTGGAGATAGCGCTGAAGGAAAAAATTACCGTTTACGATGCTCTCTACATAGCCCTTGCGGAAGAACTAAAAGC
TGAGTTTTATACCCCTGACGTTAAGCAGTTTGAGGCAGCGAAAAAATACGTGAGAGTAAAGCTCATTTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8598.98 Da        Isoelectric Point: 10.6770

>AT56116 WP_058945792.1 NZ_CP012200:c97056-96835 [Thermococcus sp. 2319x1]
MAVITVRIPDEIKAKMKGISINWSEEIRRFIIQRIEEEERRKNLQKALEILKGKKSVERGFSAKSVREDRDSN

Download         Length: 222 bp

>AT56116 NZ_CP012200:c97056-96835 [Thermococcus sp. 2319x1]
ATGGCTGTCATTACAGTTAGGATTCCAGATGAGATAAAAGCAAAGATGAAGGGAATAAGTATAAACTGGAGTGAAGAAAT
AAGGAGGTTCATAATCCAGCGCATAGAAGAGGAAGAAAGGAGGAAAAACCTCCAAAAAGCCCTTGAAATTCTCAAGGGGA
AAAAGAGCGTTGAGAGGGGTTTTTCAGCGAAATCTGTGAGGGAGGATCGTGATAGTAATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0U3QV58

Antitoxin

Source ID Structure
AlphaFold DB A0A0U3SVW6

References