Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-pasA/RelE-HTH
Location 1328006..1328493 Replicon chromosome
Accession NZ_CP012195
Organism Campylobacter ureolyticus RIGS 9880

Toxin (Protein)


Gene name relE Uniprot ID A0A0K1HHB0
Locus tag CUREO_RS06700 Protein ID WP_050335549.1
Coordinates 1328224..1328493 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID A0A0K1HGS2
Locus tag CUREO_RS06695 Protein ID WP_024962245.1
Coordinates 1328006..1328227 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CUREO_RS06660 1323543..1324310 + 768 WP_050335543.1 hypothetical protein -
CUREO_RS06685 1325759..1326343 + 585 WP_050335545.1 transglycosylase SLT domain-containing protein -
CUREO_RS06690 1326417..1327751 + 1335 WP_050335547.1 OprD family outer membrane porin -
CUREO_RS06695 1328006..1328227 + 222 WP_024962245.1 ribbon-helix-helix domain-containing protein Antitoxin
CUREO_RS06700 1328224..1328493 + 270 WP_050335549.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CUREO_RS06710 1328931..1329680 - 750 WP_050335551.1 hypothetical protein -
CUREO_RS06715 1329677..1330066 - 390 WP_018712802.1 transcription antitermination factor NusB -
CUREO_RS06720 1330067..1330537 - 471 WP_024962249.1 6,7-dimethyl-8-ribityllumazine synthase -
CUREO_RS06725 1330550..1330870 - 321 WP_018712804.1 hypothetical protein -
CUREO_RS06730 1330863..1331195 - 333 WP_024962250.1 chaperonin -
CUREO_RS06735 1331185..1331988 - 804 WP_050335553.1 3-deoxy-8-phosphooctulonate synthase -
CUREO_RS06740 1331998..1332891 - 894 WP_050335554.1 DMT family transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-84)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(4-41)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10636.57 Da        Isoelectric Point: 10.4778

>T56115 WP_050335549.1 NZ_CP012195:1328224-1328493 [Campylobacter ureolyticus RIGS 9880]
MKIELNDRAKKDFAKLDKHIQIQIFKKLKFIENLNNPKDDGKPLAGNLLGLWRYRSEDYRILAQILDDKLIILVVKISHR
KNIYDFKKQ

Download         Length: 270 bp

>T56115 NZ_CP012195:1328224-1328493 [Campylobacter ureolyticus RIGS 9880]
ATGAAAATTGAATTAAATGATAGAGCTAAAAAAGATTTTGCAAAGCTTGATAAACATATACAAATTCAGATTTTTAAAAA
ATTAAAATTTATTGAAAACTTGAATAATCCAAAAGATGACGGAAAGCCTTTGGCTGGAAATTTGCTTGGTCTTTGGAGAT
ATAGAAGTGAAGATTATAGAATATTAGCTCAAATACTAGATGATAAACTTATAATTTTAGTTGTTAAAATTTCTCACAGA
AAAAATATTTATGACTTTAAAAAACAATAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8526.55 Da        Isoelectric Point: 5.0916

>AT56115 WP_024962245.1 NZ_CP012195:1328006-1328227 [Campylobacter ureolyticus RIGS 9880]
MQLTFRLNDELSKRFEALVNETKRTKSHYLQEAVKNLLDDYDDYKEAMKSINESSGKKTYSLDEISSLYGLNV

Download         Length: 222 bp

>AT56115 NZ_CP012195:1328006-1328227 [Campylobacter ureolyticus RIGS 9880]
ATGCAACTAACTTTTAGATTAAATGATGAGTTATCAAAAAGATTTGAAGCTCTTGTAAATGAGACTAAAAGAACAAAATC
TCACTATTTGCAAGAAGCAGTTAAAAATTTGCTTGATGATTATGATGATTATAAAGAAGCTATGAAATCAATCAATGAAA
GCAGCGGTAAAAAAACCTATTCTTTAGATGAAATTTCATCTTTATATGGCTTAAATGTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K1HHB0

Antitoxin

Source ID Structure
AlphaFold DB A0A0K1HGS2

References