Detailed information of TA system TA056114

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 1232583..1233112
• Replicon: chromosome
• Accession: NZ_CP012194
• Organism: Corynebacterium glutamicum strain CP

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: AC079_RS05875
• Protein ID: WP_075348157.1
• Coordinates: 1232813..1233112 (+)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A1B4WJV4
• Locus tag: AC079_RS05870
• Protein ID: WP_060564305.1
• Coordinates: 1232583..1232816 (+)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AC079_RS05850	1228628..1229851	-	1224	WP_060564303.1	esterase family protein	-
AC079_RS05855	1230047..1231132	+	1086	WP_004568081.1	redox-regulated ATPase YchF	-
AC079_RS05860	1231297..1231542	+	246	WP_060564304.1	hypothetical protein	-
AC079_RS05865	1231876..1232316	+	441	WP_038583357.1	YtoQ family protein	-
AC079_RS05870	1232583..1232816	+	234	WP_060564305.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
AC079_RS05875	1232813..1233112	+	300	WP_075348157.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AC079_RS05880	1233151..1233417	+	267	WP_087061857.1	helix-turn-helix transcriptional regulator	-
AC079_RS05885	1233635..1234108	-	474	WP_081302985.1	SAP domain-containing protein	-
AC079_RS05890	1234274..1234786	-	513	WP_146144404.1	hypothetical protein	-
AC079_RS05895	1235006..1235464	+	459	WP_060564309.1	NUDIX domain-containing protein	-
AC079_RS05900	1235628..1236011	+	384	WP_060564310.1	class I SAM-dependent methyltransferase	-
AC079_RS05905	1236161..1237186	-	1026	WP_060564311.1	hypothetical protein	-
AC079_RS05910	1237191..1237769	-	579	WP_060564312.1	ATP-binding cassette domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-74)

Antitoxin

• Antitoxin ParD (1-76)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11529.07 Da
• Isoelectric Point: 10.6281

>T56114 WP_075348157.1 NZ_CP012194:1232813-1233112 [Corynebacterium glutamicum]
VSRYLLTPAAQHDLSLIWDFTESRWGISQAKKYIREIQSAVEYVAQDANRGRSREEIRLGYKSTAVGSHVIFYVQRTSHW
KAMKQPVWRPTSARQFVTS

Nucleotide

• Length: 300 bp

>T56114 NZ_CP012194:1232813-1233112 [Corynebacterium glutamicum]
GTGAGCAGGTACCTTCTTACACCGGCTGCACAGCATGATCTCTCCTTGATTTGGGATTTCACCGAGAGTCGTTGGGGTAT
AAGCCAAGCAAAGAAGTATATCCGTGAGATTCAATCAGCAGTGGAATATGTGGCACAAGATGCGAACCGTGGCCGTAGTC
GTGAGGAAATTCGCTTAGGTTATAAAAGCACTGCGGTAGGCAGCCATGTCATATTTTATGTCCAGCGCACGAGCCATTGG
AAGGCAATGAAACAGCCTGTCTGGAGACCGACATCGGCCAGGCAGTTCGTGACCTCATAG

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8475.39 Da
• Isoelectric Point: 4.1948

>AT56114 WP_060564305.1 NZ_CP012194:1232583-1232816 [Corynebacterium glutamicum]
MAMNTSISLDDHFASFLSEQVESGRYQTASEVIRAGLRLLEEREARLTALRAALVNGEMSGEAEEFDFDAFIASKSS

Nucleotide

• Length: 234 bp

>AT56114 NZ_CP012194:1232583-1232816 [Corynebacterium glutamicum]
ATGGCCATGAATACTTCCATCAGTCTTGATGATCATTTCGCTTCGTTCCTCAGTGAGCAGGTTGAATCCGGTCGGTACCA
GACAGCGAGTGAGGTCATCCGTGCAGGTCTGCGCTTGTTGGAGGAGCGGGAAGCTCGTCTAACTGCTTTACGTGCGGCGC
TTGTAAATGGAGAGATGAGTGGTGAGGCAGAAGAATTTGATTTTGATGCCTTTATCGCATCGAAAAGCTCGTGA

Structures

Antitoxin

• AlphaFold DB: A0A1B4WJV4