Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2379280..2379914 Replicon chromosome
Accession NZ_CP012181
Organism Pseudonocardia sp. EC080610-09

Toxin (Protein)


Gene name vapC Uniprot ID A0A0P0SM87
Locus tag AD006_RS11290 Protein ID WP_060575006.1
Coordinates 2379280..2379699 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0P0SNA2
Locus tag AD006_RS11295 Protein ID WP_060576479.1
Coordinates 2379690..2379914 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AD006_RS35335 2374889..2375129 + 241 Protein_2243 potassium-transporting ATPase subunit KdpA -
AD006_RS35340 2375309..2375501 + 193 Protein_2244 winged helix-turn-helix domain-containing protein -
AD006_RS34805 2375535..2375696 - 162 WP_168170448.1 hypothetical protein -
AD006_RS11270 2375985..2376521 + 537 WP_029239649.1 glyoxalase -
AD006_RS11275 2376818..2377033 - 216 WP_060575003.1 hypothetical protein -
AD006_RS11280 2377054..2377425 - 372 WP_075301941.1 hypothetical protein -
AD006_RS11285 2377666..2378757 - 1092 WP_060575005.1 IS630 family transposase -
AD006_RS11290 2379280..2379699 - 420 WP_060575006.1 PIN domain nuclease Toxin
AD006_RS11295 2379690..2379914 - 225 WP_060576479.1 hypothetical protein Antitoxin
AD006_RS11305 2380425..2381635 + 1211 WP_145982879.1 IS3 family transposase -
AD006_RS11310 2381797..2382159 + 363 WP_060575009.1 hypothetical protein -
AD006_RS11315 2382199..2382555 + 357 WP_082399689.1 maleylpyruvate isomerase N-terminal domain-containing protein -
AD006_RS33005 2383117..2383491 + 375 Protein_2255 helix-turn-helix domain containing protein -
AD006_RS11320 2383526..2384473 - 948 Protein_2256 IS701 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2377666..2385672 8006


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(29-127)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15252.58 Da        Isoelectric Point: 5.9251

>T56108 WP_060575006.1 NZ_CP012181:c2379699-2379280 [Pseudonocardia sp. EC080610-09]
VAVTSWLVDKSAYERMQSDRAAGMDEWSARVERGLLRLSTITRLELGFSARSGRSGREAFLRTPLSLMPIERLTPAMEDR
AFEVQMLLADRGQHRAPSIPDLLIAATAEKAGLTVLAIDKDFDLIAKVTGQPVETLAAV

Download         Length: 420 bp

>T56108 NZ_CP012181:c2379699-2379280 [Pseudonocardia sp. EC080610-09]
GTGGCGGTGACGAGCTGGCTCGTTGACAAGTCCGCCTACGAGCGGATGCAGTCGGACCGGGCCGCTGGCATGGACGAGTG
GAGCGCGCGCGTCGAGCGTGGCCTACTGCGGCTGTCGACGATCACGCGGCTTGAGCTGGGCTTCTCCGCGCGGTCGGGTA
GGTCGGGACGCGAGGCGTTCCTCAGGACGCCCCTGTCGCTTATGCCCATCGAACGCCTCACTCCGGCGATGGAGGACCGG
GCATTTGAGGTCCAGATGCTGCTCGCCGACCGAGGTCAGCATCGCGCCCCGTCGATCCCGGACCTGCTTATCGCGGCGAC
AGCCGAGAAAGCAGGGCTCACGGTGCTCGCCATTGATAAGGACTTCGACCTCATTGCAAAGGTCACGGGGCAACCGGTGG
AGACACTCGCTGCAGTGTAA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8062.94 Da        Isoelectric Point: 4.1068

>AT56108 WP_060576479.1 NZ_CP012181:c2379914-2379690 [Pseudonocardia sp. EC080610-09]
MTNVLIRGLSDAAVERIDAAASELGLSRNEFLRRKLEAGTPPSAESELTAEDWARSAEVFGDLSDPEVMDAAWR

Download         Length: 225 bp

>AT56108 NZ_CP012181:c2379914-2379690 [Pseudonocardia sp. EC080610-09]
ATGACGAACGTGCTCATCAGAGGGCTCAGCGACGCGGCGGTGGAGCGCATCGACGCGGCGGCGTCCGAGCTTGGCTTGTC
CCGCAACGAGTTCCTGCGCCGCAAGCTCGAAGCCGGTACGCCTCCGAGTGCCGAGAGCGAGCTCACGGCCGAGGACTGGG
CCCGCTCGGCAGAGGTGTTCGGAGACCTGTCCGATCCCGAGGTGATGGACGCCGCGTGGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0P0SM87

Antitoxin

Source ID Structure
AlphaFold DB A0A0P0SNA2

References