Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 115319..115845 | Replicon | plasmid p34998-210.894kb |
| Accession | NZ_CP012169 | ||
| Organism | Enterobacter hormaechei subsp. steigerwaltii strain 34998 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | LI65_RS25220 | Protein ID | WP_000323025.1 |
| Coordinates | 115558..115845 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | J5W3H0 |
| Locus tag | LI65_RS25215 | Protein ID | WP_004196370.1 |
| Coordinates | 115319..115558 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LI65_RS25185 | 110736..111473 | - | 738 | WP_008460272.1 | HupE/UreJ family protein | - |
| LI65_RS25190 | 111517..111882 | - | 366 | WP_009651956.1 | hypothetical protein | - |
| LI65_RS25195 | 111918..112766 | - | 849 | Protein_127 | IS3-like element ISSen4 family transposase | - |
| LI65_RS25200 | 112854..113876 | + | 1023 | WP_000627495.1 | IS21-like element ISSen3 family transposase | - |
| LI65_RS25205 | 113873..114655 | + | 783 | WP_001531258.1 | IS21-like element ISSen3 family helper ATPase IstB | - |
| LI65_RS25210 | 114742..114999 | - | 258 | Protein_130 | transposase | - |
| LI65_RS25215 | 115319..115558 | + | 240 | WP_004196370.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| LI65_RS25220 | 115558..115845 | + | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| LI65_RS25225 | 115912..116946 | - | 1035 | Protein_133 | IS481 family transposase | - |
| LI65_RS25230 | 117018..117176 | + | 159 | WP_013087178.1 | type I toxin-antitoxin system Hok family toxin | - |
| LI65_RS25240 | 118052..118366 | + | 315 | WP_044157807.1 | hypothetical protein | - |
| LI65_RS25245 | 118427..118888 | + | 462 | WP_013087181.1 | hypothetical protein | - |
| LI65_RS25250 | 118976..119176 | + | 201 | WP_013087182.1 | hypothetical protein | - |
| LI65_RS25255 | 119217..120008 | + | 792 | WP_013087183.1 | N-6 DNA methylase | - |
| LI65_RS25260 | 120050..120385 | + | 336 | WP_013087184.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | tet(D) / dfrA14 / sul2 / aph(3'')-Ib / aph(6)-Id / blaTEM-1B | - | 1..210894 | 210894 | |
| - | inside | IScluster/Tn | - | - | 111918..116946 | 5028 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T56093 WP_000323025.1 NZ_CP012169:115558-115845 [Enterobacter hormaechei subsp. steigerwaltii]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T56093 NZ_CP012169:115558-115845 [Enterobacter hormaechei subsp. steigerwaltii]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9018.43 Da Isoelectric Point: 4.3894
>AT56093 WP_004196370.1 NZ_CP012169:115319-115558 [Enterobacter hormaechei subsp. steigerwaltii]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLCNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLCNPKPVRVTLDEL
Download Length: 240 bp
>AT56093 NZ_CP012169:115319-115558 [Enterobacter hormaechei subsp. steigerwaltii]
ATGGGTAGCATTAACCTACGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGCGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGACTTTGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTACGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGCGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGACTTTGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|