Detailed information of TA system TA056086

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 3497835..3498573
• Replicon: chromosome
• Accession: NZ_CP012167
• Organism: Enterobacter hormaechei subsp. steigerwaltii strain 34998

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: LI65_RS17500
• Protein ID: WP_039270010.1
• Coordinates: 3498193..3498573 (+)
• Length: 127 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: LI65_RS17495
• Protein ID: WP_039270012.1
• Coordinates: 3497835..3498161 (+)
• Length: 109 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LI65_RS17465	3493876..3494751	+	876	WP_039270020.1	GTPase family protein	-
LI65_RS17470	3494964..3495665	+	702	WP_039270018.1	WYL domain-containing protein	-
LI65_RS17475	3495671..3496300	+	630	WP_039270016.1	hypothetical protein	-
LI65_RS17480	3496276..3496797	+	522	WP_158409970.1	hypothetical protein	-
LI65_RS17485	3496923..3497342	+	420	WP_039270015.1	antirestriction protein	-
LI65_RS17490	3497357..3497824	+	468	WP_080373382.1	DNA repair protein RadC	-
LI65_RS17495	3497835..3498161	+	327	WP_039270012.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
LI65_RS17500	3498193..3498573	+	381	WP_039270010.1	TA system toxin CbtA family protein	Toxin
LI65_RS17505	3498570..3498779	+	210	WP_039270008.1	hypothetical protein	-
LI65_RS17510	3499181..3499420	+	240	WP_023295270.1	DinI family protein	-
LI65_RS17515	3499484..3499846	+	363	WP_023295271.1	GtrA family protein	-
LI65_RS17520	3499843..3500757	+	915	WP_023295272.1	glycosyltransferase family 2 protein	-
LI65_RS17525	3500758..3502230	+	1473	WP_023295273.1	glucosyltransferase domain-containing protein	-
LI65_RS26990	3502246..3502671	-	426	WP_080338028.1	tail fiber assembly protein	-
LI65_RS17535	3502652..3503563	+	912	WP_157843884.1	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	gtrB	3494964..3510897	15933

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-111)

Antitoxin

• Antitoxin CbeA (4-103)

Sequences

Toxin

Protein

• Length: 127 a.a.
• Molecular weight: 13832.70 Da
• Isoelectric Point: 5.9559

>T56086 WP_039270010.1 NZ_CP012167:3498193-3498573 [Enterobacter hormaechei subsp. steigerwaltii]
MQTLPLPEPRAAEPCPSPVQVWQLLLTHLLDKHYGLTLNDTPFGDDSVIQAHINAGISLCDAVNFIVERYELVRTDHSCF
SLTEHSSLIGAIDILRARRATGLIVSSGYSTITRITTGRYQGGEAQ

Nucleotide

• Length: 381 bp

>T56086 NZ_CP012167:3498193-3498573 [Enterobacter hormaechei subsp. steigerwaltii]
ATGCAAACTTTACCCTTACCCGAACCACGGGCGGCTGAGCCATGCCCGTCGCCCGTGCAGGTCTGGCAGCTGCTGCTCAC
GCATCTGCTGGATAAACATTATGGCCTCACGCTTAACGACACGCCGTTTGGCGACGACAGCGTGATTCAGGCGCACATCA
ACGCCGGTATCTCCCTGTGTGATGCTGTCAATTTCATTGTGGAAAGGTATGAACTGGTGCGCACCGACCATAGCTGTTTC
AGCCTTACCGAACACTCTTCACTGATTGGTGCCATCGACATTCTGCGTGCCCGTCGTGCGACCGGACTGATAGTAAGCAG
CGGCTACAGTACCATTACCCGCATCACAACGGGCCGGTATCAGGGAGGAGAAGCACAGTGA

Antitoxin

Protein

• Length: 109 a.a.
• Molecular weight: 12035.60 Da
• Isoelectric Point: 6.7471

>AT56086 WP_039270012.1 NZ_CP012167:3497835-3498161 [Enterobacter hormaechei subsp. steigerwaltii]
MHSQQWGLTCSKTPYFGARLVQEGNRLHFLADRAGFTGDFSDDEALRLDQAFPLIMKQLEQMLSAGKLNPRQQQHVTLHH
IGLTCEADTLGSHGYVYIAIYPSSTVTG

Nucleotide

• Length: 327 bp

>AT56086 NZ_CP012167:3497835-3498161 [Enterobacter hormaechei subsp. steigerwaltii]
ATGCATTCTCAACAATGGGGGCTTACGTGCAGTAAAACGCCGTACTTCGGTGCTAGGCTGGTGCAGGAAGGCAACCGACT
GCACTTTCTGGCTGACCGGGCAGGATTTACCGGCGACTTCAGCGACGATGAAGCTCTTCGCCTTGACCAGGCTTTTCCGC
TGATAATGAAACAGCTGGAGCAGATGCTGTCAGCCGGTAAGCTGAATCCCCGACAGCAGCAACACGTTACCCTGCATCAC
ATCGGATTGACCTGTGAAGCCGACACGCTCGGTTCGCACGGTTATGTTTACATCGCGATTTATCCCTCTTCGACTGTAAC
CGGCTGA