Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 2701445..2702524 Replicon chromosome
Accession NZ_CP012167
Organism Enterobacter hormaechei subsp. steigerwaltii strain 34998

Toxin (Protein)


Gene name panT Uniprot ID A0A7G3F048
Locus tag LI65_RS13750 Protein ID WP_039270560.1
Coordinates 2701445..2702032 (-) Length 196 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID A0A7G3ETZ9
Locus tag LI65_RS13755 Protein ID WP_039270559.1
Coordinates 2702054..2702524 (-) Length 157 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LI65_RS13725 2697369..2698817 + 1449 WP_195207010.1 16S rRNA (cytosine(1407)-C(5))-methyltransferase RsmF -
LI65_RS13730 2698925..2699164 + 240 WP_003859885.1 YebV family protein -
LI65_RS13735 2699199..2699843 - 645 WP_015570293.1 protein-serine/threonine phosphatase -
LI65_RS13740 2700011..2700991 + 981 WP_039270562.1 VirK/YbjX family protein -
LI65_RS13745 2701037..2701216 + 180 WP_039270561.1 hypothetical protein -
LI65_RS13750 2701445..2702032 - 588 WP_039270560.1 hypothetical protein Toxin
LI65_RS13755 2702054..2702524 - 471 WP_039270559.1 SocA family protein Antitoxin
LI65_RS13760 2702846..2703163 - 318 WP_039270558.1 hypothetical protein -
LI65_RS13765 2703431..2703691 - 261 WP_039270557.1 hypothetical protein -
LI65_RS13770 2703675..2703959 - 285 WP_039270555.1 phage holin family protein -
LI65_RS27695 2704099..2704296 - 198 WP_127850788.1 hypothetical protein -
LI65_RS13775 2704326..2704760 - 435 WP_039270553.1 hypothetical protein -
LI65_RS13785 2706206..2706721 - 516 WP_039270551.1 hypothetical protein -
LI65_RS13790 2706954..2707367 - 414 WP_052685510.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(27-122)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21051.73 Da        Isoelectric Point: 4.9672

>T56077 WP_039270560.1 NZ_CP012167:c2702032-2701445 [Enterobacter hormaechei subsp. steigerwaltii]
VSIVEDIFKVIGAASGLEQIRTDSDPTKTSQSKNSNPKTESSKGSGSAEEKGKSETSDGAAPSEPDDKAEREAEEFGSNT
GALHEFMQQNRMDSLQAQLDMLKSGVRDKIADANGKEIDNVLRKKMASFTFSFMVCWCLFVGTMFVSYLIAHEGKPPPET
MIALLGTSTLSIVGLVGFVVSGLFKSRKEGSEKEK

Download         Length: 588 bp

>T56077 NZ_CP012167:c2702032-2701445 [Enterobacter hormaechei subsp. steigerwaltii]
GTGTCAATCGTGGAAGACATTTTTAAAGTCATCGGTGCGGCATCTGGGCTTGAGCAGATCCGCACCGATTCTGATCCTAC
CAAGACATCCCAATCCAAAAATAGCAATCCCAAAACAGAATCTTCAAAAGGAAGCGGTTCAGCTGAAGAAAAGGGTAAAT
CCGAAACTTCTGACGGAGCTGCACCAAGCGAACCTGACGACAAAGCAGAACGTGAAGCGGAAGAGTTTGGCTCTAATACT
GGCGCGTTGCATGAATTCATGCAGCAAAATCGTATGGATAGCTTGCAAGCACAACTGGATATGTTGAAATCAGGTGTGCG
AGATAAGATTGCTGATGCGAATGGTAAAGAAATTGACAACGTTCTTCGTAAGAAGATGGCATCCTTCACATTTTCATTTA
TGGTTTGCTGGTGCCTATTCGTTGGTACTATGTTTGTTTCTTATCTTATCGCACATGAAGGGAAGCCTCCTCCTGAAACC
ATGATTGCTTTACTTGGCACCAGTACACTTTCGATTGTTGGACTTGTTGGCTTTGTAGTTAGTGGCCTGTTTAAGTCGCG
CAAAGAAGGTAGTGAAAAAGAGAAATAA

Antitoxin


Download         Length: 157 a.a.        Molecular weight: 17314.82 Da        Isoelectric Point: 8.0154

>AT56077 WP_039270559.1 NZ_CP012167:c2702524-2702054 [Enterobacter hormaechei subsp. steigerwaltii]
MYSPVQVANRFVMLGNQHMNPLTHMQLQKLTYIAHGYYLALTGRPLINEPVSAWKYGPVIPGMYDAFKDFGNRPVTNPVM
SPYGMGVFDPQAESVIGAVFQYYGNKGGIELSTLTHLPGTPWSRAYNGFSSTIIPDGVIKSYYDDLVANRQTCQGL

Download         Length: 471 bp

>AT56077 NZ_CP012167:c2702524-2702054 [Enterobacter hormaechei subsp. steigerwaltii]
ATGTACAGTCCGGTACAGGTAGCCAATCGATTTGTTATGTTGGGCAATCAACATATGAATCCTCTGACTCATATGCAACT
TCAAAAGTTGACATACATTGCCCATGGTTATTATCTGGCTTTAACAGGGCGTCCGTTAATCAATGAACCTGTTTCTGCTT
GGAAGTATGGCCCTGTAATTCCAGGAATGTATGACGCATTTAAAGACTTTGGAAACAGGCCAGTTACAAACCCTGTCATG
AGTCCTTACGGAATGGGAGTATTCGACCCGCAAGCGGAAAGTGTCATTGGTGCAGTATTCCAATATTACGGCAACAAGGG
CGGGATTGAATTGTCCACTTTAACCCATTTACCTGGCACTCCATGGTCCAGAGCATACAACGGGTTTAGTTCTACGATTA
TACCTGACGGTGTAATCAAGTCTTACTACGATGATCTTGTTGCCAATCGGCAAACTTGTCAAGGCCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7G3F048

Antitoxin

Source ID Structure
AlphaFold DB A0A7G3ETZ9

References