Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2404102..2404841 Replicon chromosome
Accession NZ_CP012165
Organism Enterobacter hormaechei subsp. xiangfangensis strain 34978

Toxin (Protein)


Gene name tacT Uniprot ID A0A837FFP9
Locus tag LI63_RS12895 Protein ID WP_032609220.1
Coordinates 2404102..2404587 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag LI63_RS12900 Protein ID WP_003857131.1
Coordinates 2404575..2404841 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LI63_RS12870 2399422..2400237 - 816 WP_012695470.1 aminoglycoside O-phosphotransferase APH(3')-Ia -
LI63_RS12875 2400398..2401366 - 969 WP_013815099.1 IS5-like element IS903B family transposase -
LI63_RS12880 2401398..2401769 - 372 Protein_2261 IS5/IS1182 family transposase -
LI63_RS12885 2401844..2402476 + 633 WP_001567369.1 hypothetical protein -
LI63_RS12890 2402505..2403908 - 1404 WP_001567368.1 ISNCY-like element ISKpn21 family transposase -
LI63_RS12895 2404102..2404587 - 486 WP_032609220.1 GNAT family N-acetyltransferase Toxin
LI63_RS12900 2404575..2404841 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
LI63_RS12905 2404905..2405834 - 930 WP_032609221.1 LysR family transcriptional regulator -
LI63_RS12910 2405964..2407352 + 1389 WP_032609222.1 MFS transporter -
LI63_RS12915 2407374..2408369 - 996 WP_023314163.1 DUF2891 domain-containing protein -
LI63_RS12920 2408379..2409365 - 987 WP_003857123.1 DUF979 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(80-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17554.26 Da        Isoelectric Point: 9.9658

>T56061 WP_032609220.1 NZ_CP012165:c2404587-2404102 [Enterobacter hormaechei subsp. xiangfangensis]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVICKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T56061 NZ_CP012165:c2404587-2404102 [Enterobacter hormaechei subsp. xiangfangensis]
GTGGGACGTGTAACAGCGCCAGAGCCCTTATCCAGCGTCCATCAACTGGCGGAGTTCGTCAGCGGAGAGGCCGTGCTTGA
CGAATGGCTAAAACAAAGAGGTCTGAAAAACCAGGCGCTCGGCGCAGCCCGAACGTTTGTCATTTGTAAAACGGGCACGA
AGCAGGTCGCGGGATTTTACTCACTGGCTACCGGCAGCGTTAACCATACGCAAGCGACAGGTAATCTGCGGCGTAACATG
CCGGATCCCATTCCCGTGATTATACTTGCCCGTCTGGCTGTTGATGTCTCGTTACGCGGAAACGGGTTGGGAGCCGATTT
ACTCCACGATGCGGTTTTACGCTGTTATCGGGTAGCTGAGAATATCGGGGTGCGGGCGATCATGGTTCATGCACTCACTG
AGGAAGCCAAAGCGTTTTATATCCACCATGGTTTTAAAGCCTCGCAGACTCAGGAACGGACACTGTTTCTCCGGCTTCCT
CAGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT56061 WP_003857131.1 NZ_CP012165:c2404841-2404575 [Enterobacter hormaechei subsp. xiangfangensis]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT56061 NZ_CP012165:c2404841-2404575 [Enterobacter hormaechei subsp. xiangfangensis]
ATGAAATCAGATGTTCAACTCAATCTCAGAGCCAAAGAATCCCAGCGGGCGCTTATCGATGCCGCCGCAGAGATCCTCCA
TAAATCACGTACAGACTTCATTCTGGAGATGGCCTGTCAGGCAGCCGAGAATGTGATCCTCGATCGACGTGTATTCAATT
TTAACGATGAACAGTACGCAGAGTTCATTGACATGCTCGATGCCCCGGTCGCGGACGATCCTGCCATAGAAAAACTGCTG
GCAAGGAAACCGCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFP9

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References