Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 708387..709066 Replicon chromosome
Accession NZ_CP012165
Organism Enterobacter hormaechei subsp. xiangfangensis strain 34978

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag LI63_RS04840 Protein ID WP_032608412.1
Coordinates 708725..709066 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag LI63_RS04835 Protein ID WP_020456353.1
Coordinates 708387..708704 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LI63_RS04800 703676..704500 + 825 Protein_663 DUF945 domain-containing protein -
LI63_RS04805 704709..705392 + 684 WP_044596278.1 DeoR family transcriptional regulator -
LI63_RS04810 705631..706497 + 867 WP_032608409.1 hypothetical protein -
LI63_RS26520 706625..706825 + 201 WP_050596949.1 DUF905 family protein -
LI63_RS04815 706931..707389 + 459 WP_032608410.1 antirestriction protein -
LI63_RS04820 707399..707617 + 219 WP_020456350.1 hypothetical protein -
LI63_RS04825 707660..708139 + 480 WP_020456351.1 DNA repair protein RadC -
LI63_RS04830 708148..708369 + 222 WP_032608411.1 DUF987 domain-containing protein -
LI63_RS04835 708387..708704 + 318 WP_020456353.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
LI63_RS04840 708725..709066 + 342 WP_032608412.1 TA system toxin CbtA family protein Toxin
LI63_RS04845 709321..710328 + 1008 WP_020456355.1 restriction endonuclease -
LI63_RS04850 710509..711378 - 870 WP_032608413.1 HNH endonuclease -
LI63_RS26235 711679..712152 + 474 WP_072163380.1 SymE family type I addiction module toxin -
LI63_RS04860 712232..712603 - 372 WP_032608414.1 hypothetical protein -
LI63_RS04865 712718..712966 - 249 WP_032608415.1 bacteriocin immunity protein -
LI63_RS04870 713025..713249 - 225 WP_032608417.1 hypothetical protein -
LI63_RS04875 713322..713573 - 252 WP_032608418.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island fosA - 678007..729463 51456


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-109)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12747.73 Da        Isoelectric Point: 9.0060

>T56059 WP_032608412.1 NZ_CP012165:708725-709066 [Enterobacter hormaechei subsp. xiangfangensis]
MKTLPATTPQAVTLCLSPVAVWQMLLARLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNFLVEKYGLVRIDRRGF
NWQEQSPYLRAVDILRARQATGLLKRNRISAAR

Download         Length: 342 bp

>T56059 NZ_CP012165:708725-709066 [Enterobacter hormaechei subsp. xiangfangensis]
ATGAAAACTCTACCTGCAACAACTCCGCAGGCGGTGACGCTATGTCTGTCGCCCGTGGCAGTGTGGCAAATGCTGCTTGC
ACGCCTGCTGGAACAACATTATGGCCTGACACTCAACGACACACCATTCAGTGATGAAACGGTAATTCAGGAACATATCG
ATGCCGGTATATCTTTGGCCGATGCCGTTAATTTTCTGGTGGAAAAGTACGGGCTGGTTCGTATTGATCGCAGGGGATTC
AACTGGCAAGAACAGTCCCCATATCTGCGGGCGGTCGATATTCTGCGGGCGCGACAGGCAACTGGTTTATTGAAAAGAAA
TCGTATTAGCGCGGCACGGTGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11846.39 Da        Isoelectric Point: 5.5403

>AT56059 WP_020456353.1 NZ_CP012165:708387-708704 [Enterobacter hormaechei subsp. xiangfangensis]
MSNTTWGLQRDITPRLGARLVQEGNWLHYLADRASITGKFSEAECLKLDVVFPNFISQLESMLTTGEMNPSHAYCVTLYH
NGFTCEADTLGSYGYVYIAVYPTQR

Download         Length: 318 bp

>AT56059 NZ_CP012165:708387-708704 [Enterobacter hormaechei subsp. xiangfangensis]
ATGAGCAACACCACATGGGGACTGCAGCGGGATATCACGCCGCGCCTGGGAGCACGTCTGGTTCAGGAGGGCAACTGGCT
GCACTATTTGGCTGACCGAGCCAGTATTACCGGTAAATTCAGCGAAGCAGAATGTCTTAAGCTGGATGTGGTATTTCCGA
ATTTTATCAGCCAGTTGGAGTCAATGCTTACCACTGGTGAAATGAACCCTAGCCATGCCTATTGTGTCACCCTGTACCAC
AATGGTTTCACCTGCGAAGCCGATACCCTTGGCAGTTACGGCTACGTATACATCGCCGTTTACCCCACTCAACGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References