Detailed information of TA system TA056057

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3959574..3960231
• Replicon: chromosome
• Accession: NZ_CP012162
• Organism: Enterobacter roggenkampii strain 35734

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: W7P4L3
• Locus tag: LI67_RS19410
• Protein ID: WP_023326024.1
• Coordinates: 3959574..3959984 (-)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: W7NX65
• Locus tag: LI67_RS19415
• Protein ID: WP_006178375.1
• Coordinates: 3959965..3960231 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LI67_RS19390	3955567..3957300	-	1734	WP_044597689.1	single-stranded-DNA-specific exonuclease RecJ	-
LI67_RS19395	3957306..3958019	-	714	WP_044597688.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
LI67_RS19400	3958048..3958944	-	897	WP_044597687.1	site-specific tyrosine recombinase XerD	-
LI67_RS19405	3959046..3959567	+	522	WP_044597686.1	flavodoxin FldB	-
LI67_RS19410	3959574..3959984	-	411	WP_023326024.1	protein YgfX	Toxin
LI67_RS19415	3959965..3960231	-	267	WP_006178375.1	FAD assembly factor SdhE	Antitoxin
LI67_RS19420	3960526..3961506	+	981	WP_044597685.1	tRNA-modifying protein YgfZ	-
LI67_RS19425	3961591..3962250	-	660	WP_021242052.1	hemolysin III family protein	-
LI67_RS19430	3962516..3963247	+	732	WP_021242053.1	MurR/RpiR family transcriptional regulator	-
LI67_RS19435	3963364..3964797	+	1434	WP_044597684.1	6-phospho-beta-glucosidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 16063.06 Da
• Isoelectric Point: 10.9468

>T56057 WP_023326024.1 NZ_CP012162:c3959984-3959574 [Enterobacter roggenkampii]
VVLWQSDLRVSWRSQWMSLLLHGLVAAIVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNCGMMLRLRKVDGGRCQHLWLAADSMDAAEWRDLRRMLLQQTTQG

Nucleotide

• Length: 411 bp

>T56057 NZ_CP012162:c3959984-3959574 [Enterobacter roggenkampii]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCGCAGTGGATGTCTTTATTGCTCCACGGCCTGGTTGCGGC
CATTGTGTTACTGATGCCGTGGCCGCTGAGCTATACGCCGCTGTGGCTGCTGTTGCTCTCATTTGTCGTTTTTGACAGCG
TACGCAGCCAGCGACGCATTAATGCCCGTCAGGGAGAGATTAAATTACTGATGGATTCCCGCCTGCGCTGGCAGGGTAAA
GAGTGGGATATTCTCGGTATGCCCTGGATGCTCAACTGCGGCATGATGTTACGGTTACGCAAGGTGGACGGCGGGCGTTG
CCAGCATCTGTGGCTGGCGGCTGACAGTATGGATGCTGCCGAATGGCGAGACCTGCGCCGGATGCTGTTGCAACAGACGA
CGCAGGGGTAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10569.05 Da
• Isoelectric Point: 5.1340

>AT56057 WP_006178375.1 NZ_CP012162:c3960231-3959965 [Enterobacter roggenkampii]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT56057 NZ_CP012162:c3960231-3959965 [Enterobacter roggenkampii]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATTTCCATCATGCCTTT
CTTCGAATATGAGTATGACACCTTAAGCGACGACGATAAGCGTCTGTTTGTTCGCCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAACCACGGCAAACCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Toxin

• AlphaFold DB: W7P4L3

Antitoxin

• AlphaFold DB: W7NX65