Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 270705..271301 Replicon chromosome
Accession NZ_CP012162
Organism Enterobacter roggenkampii strain 35734

Toxin (Protein)


Gene name PumA Uniprot ID A0A0F1DED9
Locus tag LI67_RS02035 Protein ID WP_023293553.1
Coordinates 270999..271301 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A837LKY9
Locus tag LI67_RS02030 Protein ID WP_044598004.1
Coordinates 270705..270992 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LI67_RS02025 269077..270708 + 1632 WP_008503411.1 Na/Pi cotransporter family protein -
LI67_RS02030 270705..270992 - 288 WP_044598004.1 putative addiction module antidote protein Antitoxin
LI67_RS02035 270999..271301 - 303 WP_023293553.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LI67_RS02040 271499..272371 + 873 WP_039024655.1 23S rRNA pseudouridine(2604) synthase RluF -
LI67_RS02045 272372..272644 - 273 WP_014830263.1 DUF3811 domain-containing protein -
LI67_RS02050 272695..273639 - 945 WP_044597329.1 ketopantoate/pantoate/pantothenate transporter PanS -
LI67_RS02055 273745..275319 - 1575 WP_044597328.1 RNA repair transcriptional activator RtcR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-93)

Antitoxin

Uncharacterized protein HI1420

(4-90)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11459.24 Da        Isoelectric Point: 10.1771

>T56045 WP_023293553.1 NZ_CP012162:c271301-270999 [Enterobacter roggenkampii]
MKEIVQTESFRRWEQNLKDRRAKTIIASRLFRLANGLAGDVKPVGEGISELRIHFGPGYRIYFKDQGNYIIVLLCGGDKS
SQARDILMAKMLSNVSQWQE

Download         Length: 303 bp

>T56045 NZ_CP012162:c271301-270999 [Enterobacter roggenkampii]
ATGAAGGAGATTGTTCAGACAGAATCCTTCCGACGCTGGGAGCAAAACTTAAAAGATCGACGAGCGAAGACCATTATCGC
TTCCCGCCTCTTTCGGTTGGCAAATGGCTTGGCGGGCGACGTTAAACCCGTGGGAGAAGGTATAAGTGAGCTAAGGATCC
ACTTTGGTCCGGGCTACAGGATCTATTTTAAAGACCAGGGCAATTACATCATCGTGCTGTTATGTGGTGGTGACAAAAGC
AGCCAGGCCAGAGACATACTGATGGCAAAAATGCTGAGCAATGTATCCCAATGGCAGGAGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10142.50 Da        Isoelectric Point: 5.6306

>AT56045 WP_044598004.1 NZ_CP012162:c270992-270705 [Enterobacter roggenkampii]
MHNLTPYDPANALVDDEEIAVFIADALETGDSTYIAKALGVVARAKGMSNISQQTGLSREQLYRSFSDKGNPTLKTTLAV
MKALGFGLTLKHAGD

Download         Length: 288 bp

>AT56045 NZ_CP012162:c270992-270705 [Enterobacter roggenkampii]
ATGCATAACTTAACACCTTACGATCCCGCCAACGCGTTGGTGGATGACGAGGAAATCGCCGTGTTTATCGCTGATGCACT
AGAAACAGGCGACTCGACATATATCGCTAAAGCCCTTGGTGTTGTCGCGCGAGCCAAAGGCATGTCGAACATTTCACAGC
AAACCGGTTTATCACGTGAGCAGCTTTATCGGTCATTCAGTGATAAAGGAAACCCAACGCTCAAAACCACGCTCGCGGTC
ATGAAAGCATTGGGTTTTGGGCTAACACTCAAACACGCCGGGGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F1DED9

Antitoxin

Source ID Structure
AlphaFold DB A0A837LKY9

References