Detailed information of TA system TA056044

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-MazE
• Location: 46065..46726
• Replicon: chromosome
• Accession: NZ_CP012162
• Organism: Enterobacter roggenkampii strain 35734

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: LI67_RS01030
• Protein ID: WP_023293716.1
• Coordinates: 46328..46726 (+)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A156KC23
• Locus tag: LI67_RS01025
• Protein ID: WP_032675702.1
• Coordinates: 46065..46331 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LI67_RS01000	42118..43446	-	1329	WP_025910681.1	PTS sugar transporter subunit IIC	-
LI67_RS01005	43458..43772	-	315	WP_008500132.1	PTS sugar transporter subunit IIB	-
LI67_RS01010	44066..45016	+	951	WP_023293714.1	LacI family transcriptional regulator	-
LI67_RS01015	45078..45374	-	297	WP_044597403.1	hypothetical protein	-
LI67_RS01020	45516..45935	+	420	WP_008500129.1	GNAT family N-acetyltransferase	-
LI67_RS01025	46065..46331	+	267	WP_032675702.1	virulence protein	Antitoxin
LI67_RS01030	46328..46726	+	399	WP_023293716.1	type II toxin-antitoxin system VapC family toxin	Toxin
LI67_RS01035	46866..47666	+	801	WP_008500128.1	lipoprotein NlpA	-
LI67_RS01040	47789..48568	+	780	WP_044597402.1	MBL fold metallo-hydrolase	-
LI67_RS01045	48595..49548	+	954	WP_044597401.1	helix-turn-helix domain-containing protein	-
LI67_RS01050	49788..51428	+	1641	WP_044598011.1	ShlB/FhaC/HecB family hemolysin secretion/activation protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-121)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 14799.00 Da
• Isoelectric Point: 6.4779

>T56044 WP_023293716.1 NZ_CP012162:46328-46726 [Enterobacter roggenkampii]
MRHMLDTNIVSHLFKRHPEVVSRMTCLAPGDVCISSITEAELLYGADKKKSSRLKETIREFLNTITICDWDSDAAATYGE
LRATLEKKGKVMGDLDQLIAAHAISRGTTIVTNDRAFRMVQELAVEDWTTTL

Nucleotide

• Length: 399 bp

>T56044 NZ_CP012162:46328-46726 [Enterobacter roggenkampii]
ATGAGACATATGCTGGATACGAATATTGTGAGTCACTTGTTTAAACGACACCCGGAGGTTGTAAGCAGAATGACATGTCT
GGCGCCGGGTGACGTTTGTATCTCAAGCATTACCGAAGCGGAATTGCTGTATGGTGCTGACAAGAAGAAAAGCAGTAGAT
TGAAAGAAACAATCCGGGAGTTTCTCAATACCATCACGATTTGCGACTGGGACAGCGACGCCGCAGCAACGTACGGTGAA
CTCCGTGCAACCCTGGAAAAGAAAGGGAAAGTGATGGGGGATCTCGATCAACTGATCGCTGCACATGCTATCAGTCGGGG
AACAACGATCGTTACTAACGATCGTGCATTCAGAATGGTGCAGGAGCTTGCTGTCGAGGACTGGACGACAACGTTGTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10009.34 Da
• Isoelectric Point: 4.6310

>AT56044 WP_032675702.1 NZ_CP012162:46065-46331 [Enterobacter roggenkampii]
MERTAKLFRKGQNQAVMLPAEFAFDTESVYIRRDEEGNVVLAAKPVLIKSWDNFLRMLAETDVPDTFLSKEERNQSVTTR
DPLDGACS

Nucleotide

• Length: 267 bp

>AT56044 NZ_CP012162:46065-46331 [Enterobacter roggenkampii]
ATGGAACGCACAGCAAAACTATTCAGAAAGGGTCAGAATCAGGCCGTTATGCTGCCTGCTGAATTCGCGTTTGATACGGA
GAGCGTCTACATCCGACGGGATGAGGAGGGGAATGTCGTTTTGGCGGCAAAACCTGTTCTAATAAAGAGCTGGGATAATT
TTCTCCGCATGCTGGCAGAAACGGACGTACCAGATACGTTTTTGAGCAAGGAGGAACGCAATCAGAGTGTTACGACAAGA
GACCCTCTGGATGGAGCATGCTCATGA

Structures

Antitoxin

• AlphaFold DB: A0A156KC23