Detailed information of TA system TA056042

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/CC2985(antitoxin)
• Location: 3451298..3451832
• Replicon: chromosome
• Accession: NZ_CP012154
• Organism: Wenzhouxiangella marina strain KCTC 42284

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A0K0XZX0
• Locus tag: WM2015_RS14475
• Protein ID: WP_049726729.1
• Coordinates: 3451298..3451597 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: WM2015_RS14480
• Protein ID: WP_211261014.1
• Coordinates: 3451602..3451832 (-)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
WM2015_RS14440	3446395..3446895	-	501	WP_049726722.1	hypothetical protein	-
WM2015_RS15960	3446892..3447380	-	489	WP_169751198.1	MarR family transcriptional regulator	-
WM2015_RS14450	3447596..3448156	-	561	WP_049726724.1	hypothetical protein	-
WM2015_RS14455	3448292..3448579	+	288	WP_049726725.1	3'-5' exonuclease	-
WM2015_RS14460	3448824..3449279	+	456	WP_082169795.1	hypothetical protein	-
WM2015_RS14465	3449398..3450501	-	1104	WP_049726727.1	DUF2855 family protein	-
WM2015_RS14470	3450628..3451254	+	627	WP_049726728.1	hypothetical protein	-
WM2015_RS14475	3451298..3451597	-	300	WP_049726729.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
WM2015_RS14480	3451602..3451832	-	231	WP_211261014.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
WM2015_RS14485	3451989..3452570	+	582	WP_049726730.1	class I SAM-dependent methyltransferase	-
WM2015_RS15965	3452860..3453489	+	630	WP_156201258.1	hypothetical protein	-
WM2015_RS14490	3453587..3454507	+	921	WP_169751199.1	CPBP family intramembrane metalloprotease	-
WM2015_RS14495	3454508..3455368	-	861	WP_049727111.1	phosphotransferase	-
WM2015_RS14500	3455448..3455924	-	477	WP_156201260.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3427738..3454507	26769

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-92)

Antitoxin

• Antitoxin ParD (5-62)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11389.83 Da
• Isoelectric Point: 5.4711

>T56042 WP_049726729.1 NZ_CP012154:c3451597-3451298 [Wenzhouxiangella marina]
MAYRLTRKAADDVLNIYAFGAERFGPEQADAYHALLQRTFEFLAANPHAAWQRTELTPPVRIHPLQSHLVIYLIEDDGEI
LIIRVRHGHEDWADPQTAE

Nucleotide

• Length: 300 bp

>T56042 NZ_CP012154:c3451597-3451298 [Wenzhouxiangella marina]
ATGGCCTACCGGCTGACGCGTAAAGCGGCCGATGACGTTCTGAATATCTACGCCTTCGGCGCCGAGCGCTTCGGCCCCGA
GCAGGCAGATGCCTACCATGCGCTGTTGCAGCGTACCTTCGAATTCCTGGCCGCCAATCCCCATGCCGCGTGGCAGCGAA
CCGAGTTGACACCGCCCGTTCGGATTCACCCGCTGCAGTCTCATCTGGTGATTTATCTGATCGAGGATGACGGTGAAATT
CTGATCATCCGAGTCCGCCACGGGCACGAAGACTGGGCCGATCCGCAGACCGCAGAGTAG

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8710.79 Da
• Isoelectric Point: 6.3347

>AT56042 WP_211261014.1 NZ_CP012154:c3451832-3451602 [Wenzhouxiangella marina]
MNVSIPEEMKRWVEDQRKTGRFGNSSDYVRDLIRRDQERQAKIADLQALVKEGVESGPSEMTMSDLLQAARKQAQS

Nucleotide

• Length: 231 bp

>AT56042 NZ_CP012154:c3451832-3451602 [Wenzhouxiangella marina]
ATGAACGTATCCATCCCCGAAGAAATGAAGCGCTGGGTGGAAGACCAGCGCAAGACGGGGCGCTTTGGCAACTCCAGTGA
CTACGTCCGCGACCTGATCCGCCGAGATCAGGAGCGGCAGGCGAAAATTGCCGATCTGCAGGCCCTGGTGAAAGAAGGCG
TAGAGAGCGGACCCAGTGAAATGACTATGTCCGATCTGCTGCAAGCTGCCCGAAAGCAAGCGCAGTCCTGA

Structures

Toxin

• AlphaFold DB: A0A0K0XZX0