Detailed information of TA system TA056041

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 3421923..3422650
• Replicon: chromosome
• Accession: NZ_CP012154
• Organism: Wenzhouxiangella marina strain KCTC 42284

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: WM2015_RS14345
• Protein ID: WP_049726704.1
• Coordinates: 3422189..3422650 (+)
• Length: 154 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A0K0XZU8
• Locus tag: WM2015_RS14340
• Protein ID: WP_049726703.1
• Coordinates: 3421923..3422192 (+)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
WM2015_RS14325	3417153..3417542	+	390	WP_049726700.1	nucleotide pyrophosphohydrolase	-
WM2015_RS14330	3417560..3419098	-	1539	WP_049726701.1	DNA photolyase family protein	-
WM2015_RS14335	3419274..3421739	-	2466	WP_211260939.1	DUF305 domain-containing protein	-
WM2015_RS14340	3421923..3422192	+	270	WP_049726703.1	ribbon-helix-helix protein, CopG family	Antitoxin
WM2015_RS14345	3422189..3422650	+	462	WP_049726704.1	type II toxin-antitoxin system VapC family toxin	Toxin
WM2015_RS14350	3422776..3424596	-	1821	WP_049726705.1	hypothetical protein	-
WM2015_RS14355	3424750..3425001	+	252	WP_049726706.1	hypothetical protein	-
WM2015_RS14360	3425056..3425406	+	351	WP_049726707.1	hypothetical protein	-
WM2015_RS14365	3425856..3426158	+	303	WP_049726708.1	type II toxin-antitoxin system HigB family toxin	-
WM2015_RS14370	3426167..3426547	+	381	WP_049726709.1	transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-134)

Antitoxin

• Ribbon-helix-helix protein, CopG (2-40)

Sequences

Toxin

Protein

• Length: 154 a.a.
• Molecular weight: 17014.26 Da
• Isoelectric Point: 5.7848

>T56041 WP_049726704.1 NZ_CP012154:3422189-3422650 [Wenzhouxiangella marina]
VIVPDVNLLIYAVNEDAPQHDRARRWLEEALSGTSPVGLPWLVIIAFLRLSTHPRIFESPLPTDTALRLVNGWLAQPCAR
AIEPGERHWLILSQLLRDSGTAGNLSNDAHLAAIAIEHDACLHSADHDFRRFAGLRCHNPLSDYTVQEPGEAY

Nucleotide

• Length: 462 bp

>T56041 NZ_CP012154:3422189-3422650 [Wenzhouxiangella marina]
GTGATCGTTCCAGACGTCAACCTGTTGATCTACGCCGTCAACGAGGATGCACCACAGCACGACCGCGCTCGCCGCTGGCT
CGAAGAGGCCTTGTCCGGGACCTCACCGGTCGGCCTGCCCTGGCTGGTCATCATTGCCTTCCTGCGACTGAGCACCCACC
CGCGCATCTTCGAATCCCCGCTGCCGACGGACACGGCGCTCAGACTGGTCAATGGCTGGCTCGCCCAACCCTGCGCACGA
GCTATCGAACCGGGGGAGCGACACTGGCTGATCCTGTCGCAGCTGCTGCGTGATTCAGGGACAGCGGGCAACCTCAGCAA
CGATGCACATCTGGCGGCCATCGCCATCGAACACGATGCCTGCCTGCACAGCGCAGACCATGACTTCCGGCGCTTTGCCG
GATTGCGTTGCCACAACCCGCTCTCCGACTACACCGTACAGGAGCCTGGGGAAGCGTACTGA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10060.39 Da
• Isoelectric Point: 9.9142

>AT56041 WP_049726703.1 NZ_CP012154:3421923-3422192 [Wenzhouxiangella marina]
MRTTLTIDDELARQLKQRALDTGRSFKDVVNDALRDGLARTGAANPGRPYRIETARLGRTRPGIDLDKSLQLAGELEDEE
VLRKLEQRK

Nucleotide

• Length: 270 bp

>AT56041 NZ_CP012154:3421923-3422192 [Wenzhouxiangella marina]
ATGCGCACCACGCTCACCATCGACGACGAACTGGCCCGCCAGCTCAAGCAGCGCGCCCTCGACACGGGGCGGAGTTTCAA
GGACGTCGTCAACGATGCATTGCGGGACGGCCTGGCCAGGACCGGGGCCGCGAACCCCGGCCGCCCGTACCGCATCGAAA
CGGCCCGCCTGGGTCGAACCCGACCGGGGATCGACCTGGACAAGTCACTGCAGCTGGCGGGCGAACTCGAGGACGAAGAA
GTGCTGCGAAAGCTGGAGCAGCGCAAGTGA

Structures

Antitoxin

• AlphaFold DB: A0A0K0XZU8