Detailed information of TA system TA056040

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 924035..924579
• Replicon: chromosome
• Accession: NZ_CP012154
• Organism: Wenzhouxiangella marina strain KCTC 42284

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: A0A0K0XU25
• Locus tag: WM2015_RS03970
• Protein ID: WP_049724826.1
• Coordinates: 924035..924334 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: -
• Locus tag: WM2015_RS03975
• Protein ID: WP_049724827.1
• Coordinates: 924334..924579 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
WM2015_RS03955	921271..923388	+	2118	WP_082169417.1	FG-GAP repeat protein	-
WM2015_RS03960	923515..923748	+	234	WP_049724824.1	hypothetical protein	-
WM2015_RS03965	923735..923998	+	264	WP_049724825.1	type II toxin-antitoxin system RelE/ParE family toxin	-
WM2015_RS03970	924035..924334	-	300	WP_049724826.1	CcdB family protein	Toxin
WM2015_RS03975	924334..924579	-	246	WP_049724827.1	type II toxin-antitoxin system CcdA family antitoxin	Antitoxin
WM2015_RS03980	924846..925415	+	570	WP_156200830.1	hypothetical protein	-
WM2015_RS03985	925415..926002	+	588	WP_049724829.1	hypothetical protein	-
WM2015_RS03990	926077..926520	-	444	WP_049724830.1	protein-export chaperone SecB	-
WM2015_RS03995	926498..926911	-	414	WP_049724831.1	helix-turn-helix transcriptional regulator	-
WM2015_RS04000	926932..927321	-	390	WP_049724832.1	type II toxin-antitoxin system RelE/ParE family toxin	-
WM2015_RS15760	927366..927890	-	525	WP_049724833.1	hypothetical protein	-
WM2015_RS04010	927920..928132	-	213	WP_049724834.1	type II toxin-antitoxin system HicB family antitoxin	-
WM2015_RS04015	928132..928353	-	222	WP_049724835.1	type II toxin-antitoxin system HicA family toxin	-
WM2015_RS04020	928340..928567	-	228	WP_049724836.1	type II toxin-antitoxin system HicB family antitoxin	-
WM2015_RS15765	928635..929213	-	579	WP_156200832.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin CcdB (5-98)

Antitoxin

• Post-segregation antitoxin CcdA (11-81)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 10965.42 Da
• Isoelectric Point: 4.0414

>T56040 WP_049724826.1 NZ_CP012154:c924334-924035 [Wenzhouxiangella marina]
MARSDLFRNENEEDYLLDVQSELLSGLNTRVVVPLLPRSSGPAAAEHLNPVFIIQDQEVVMATQFMAAVPQSELRTAFDS
LEAKRDEIAAALDTLFLGF

Nucleotide

• Length: 300 bp

>T56040 NZ_CP012154:c924334-924035 [Wenzhouxiangella marina]
ATGGCCCGCTCTGATCTGTTCAGGAACGAAAACGAAGAGGACTATTTGCTCGACGTCCAGTCAGAGCTCCTGAGCGGCCT
AAATACACGAGTCGTCGTGCCGCTGCTGCCCAGGTCTTCAGGCCCGGCAGCTGCCGAGCACCTCAATCCCGTCTTTATCA
TCCAGGATCAGGAAGTGGTGATGGCGACGCAGTTCATGGCCGCAGTTCCACAGAGCGAATTGCGCACTGCATTCGACAGC
CTCGAGGCGAAGCGAGACGAGATCGCGGCAGCGCTGGATACGCTGTTCCTCGGCTTCTGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8958.09 Da
• Isoelectric Point: 10.7123

>AT56040 WP_049724827.1 NZ_CP012154:c924579-924334 [Wenzhouxiangella marina]
MQATKRKESSRKAANLSLDSALLEEARALGINISRSAEAGIAEAVKQHKRARWLRENASALASSNEYVEANGLPLSRYRQ
F

Nucleotide

• Length: 246 bp

>AT56040 NZ_CP012154:c924579-924334 [Wenzhouxiangella marina]
ATGCAAGCTACCAAAAGGAAAGAATCCAGCCGTAAAGCTGCCAATCTGTCGCTTGACAGCGCGCTGCTGGAAGAGGCCAG
AGCCCTCGGGATCAATATTTCCCGGTCAGCGGAGGCAGGCATCGCCGAGGCTGTGAAGCAGCACAAGAGGGCGCGGTGGC
TACGAGAAAACGCCAGCGCTCTCGCGAGTTCGAACGAATACGTCGAAGCGAATGGTTTGCCGCTGTCCCGCTACCGGCAG
TTCTGA

Structures

Toxin

• AlphaFold DB: A0A0K0XU25