Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 195323..195959 Replicon chromosome
Accession NZ_CP012152
Organism Anoxybacillus gonensis strain G2

Toxin (Protein)


Gene name mazF Uniprot ID L7ZVP1
Locus tag AFK25_RS01105 Protein ID WP_003253417.1
Coordinates 195609..195959 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID M8DWL2
Locus tag AFK25_RS01100 Protein ID WP_003398486.1
Coordinates 195323..195604 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AFK25_RS01080 191009..192415 + 1407 WP_009362372.1 DEAD/DEAH box helicase -
AFK25_RS01085 192463..192825 + 363 WP_009362371.1 holo-ACP synthase -
AFK25_RS01090 192900..193919 + 1020 WP_009362370.1 outer membrane lipoprotein carrier protein LolA -
AFK25_RS01095 194013..195170 + 1158 WP_009362369.1 alanine racemase -
AFK25_RS01100 195323..195604 + 282 WP_003398486.1 hypothetical protein Antitoxin
AFK25_RS01105 195609..195959 + 351 WP_003253417.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
AFK25_RS01110 196040..198181 + 2142 WP_049720922.1 RNA-binding transcriptional accessory protein -
AFK25_RS14950 198176..198289 - 114 WP_012573928.1 cortex morphogenetic protein CmpA -
AFK25_RS01115 198362..198817 + 456 WP_035067685.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12992.00 Da        Isoelectric Point: 4.8781

>T56038 WP_003253417.1 NZ_CP012152:195609-195959 [Anoxybacillus gonensis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLGLIDF

Download         Length: 351 bp

>T56038 NZ_CP012152:195609-195959 [Anoxybacillus gonensis]
TTGATTGTCAAACGTGGTGACGTGTATTTTGCCGATCTTTCTCCAGTAGTGGGATCTGAGCAAGGGGGCGTGCGCCCTGT
GCTTGTTATTCAAAATGACATTGGGAACCGTTTCAGTCCAACCGTCATTGTTGCTGCCATTACTGCGCAAATCCAAAAAG
CGAAGTTGCCTACACATGTTGAAATCGACGCAAAGCGCTACGGATTTGAACGGGACTCTGTCATTTTGCTTGAACAAATT
CGGACGATTGATAAACAGCGTCTGACAGATAAGATTACCCATCTAGATGACGAGATGATGGATAAAGTAGATGAAGCGTT
GCAAATTAGTCTCGGTCTTATTGATTTTTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10606.17 Da        Isoelectric Point: 7.0147

>AT56038 WP_003398486.1 NZ_CP012152:195323-195604 [Anoxybacillus gonensis]
VSESSATTEIVIRLPQALVSELDGIVKQENGSRNELIYQAMKMYIRERKKRQIREAMRRGYMEMAKINLSLASEAFLAEY
EADHTVERLVSGG

Download         Length: 282 bp

>AT56038 NZ_CP012152:195323-195604 [Anoxybacillus gonensis]
GTGTCTGAATCCAGCGCAACAACAGAAATTGTTATTCGGTTACCGCAGGCGTTAGTGAGCGAATTAGATGGAATTGTGAA
GCAAGAAAACGGCAGCCGAAATGAGCTCATTTATCAAGCGATGAAAATGTACATCCGCGAACGGAAAAAACGTCAAATTC
GAGAAGCGATGAGACGTGGGTATATGGAGATGGCGAAAATTAATTTGTCGCTTGCATCGGAGGCTTTTCTTGCGGAATAT
GAAGCTGACCACACCGTTGAACGCTTAGTTAGCGGGGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9ERQ4

Antitoxin

Source ID Structure
AlphaFold DB M8DWL2

References