Detailed information of TA system TA056027

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 1246311..1247089
• Replicon: chromosome
• Accession: NZ_CP012146
• Organism: Xanthomonas campestris pv. campestris strain ICMP 4013

Toxin (Protein)

• Gene name: TacT2
• Uniprot ID: Q8P667
• Locus tag: AEA01_RS05195
• Protein ID: WP_011038220.1
• Coordinates: 1246311..1246802 (-)
• Length: 164 a.a.

Antitoxin (Protein)

• Gene name: TacA2
• Uniprot ID: Q8P668
• Locus tag: AEA01_RS05200
• Protein ID: WP_011038219.1
• Coordinates: 1246799..1247089 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AEA01_RS05180	1242639..1243514	+	876	WP_011038222.1	30S ribosomal protein S6--L-glutamate ligase	-
AEA01_RS05185	1244164..1244841	+	678	WP_003490678.1	response regulator transcription factor	-
AEA01_RS05190	1244834..1246168	+	1335	WP_019237347.1	HAMP domain-containing histidine kinase	-
AEA01_RS05195	1246311..1246802	-	492	WP_011038220.1	GNAT family N-acetyltransferase	Toxin
AEA01_RS05200	1246799..1247089	-	291	WP_011038219.1	DUF1778 domain-containing protein	Antitoxin
AEA01_RS05205	1247164..1247565	-	402	WP_019237348.1	type I toxin-antitoxin system SymE family toxin	-
AEA01_RS05210	1248028..1249395	+	1368	WP_011035783.1	IS5-like element IS1478 family transposase	-
AEA01_RS05215	1249609..1250232	-	624	WP_011038217.1	dephospho-CoA kinase	-
AEA01_RS05220	1250246..1251109	-	864	WP_011038216.1	A24 family peptidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1248058..1249395	1337

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (42-144)

Antitoxin

• Vibrio phage ICP1, Orf50 (1-95)

Sequences

Toxin

Protein

• Length: 164 a.a.
• Molecular weight: 17638.31 Da
• Isoelectric Point: 8.1192

>T56027 WP_011038220.1 NZ_CP012146:c1246802-1246311 [Xanthomonas campestris pv. campestris]
MTVSAPEPLTAHHRVEPFASGVESLDHWLKRRALKNQATGASRTFVACEDDRVVAYYALASSAVAVDATPGRFRRNMPDP
IPVVVLGRLAVDQSLHGRGFGRALMQDAGKRILHAADTIGIRGLLVHALSADAKAFYERIGFEPSPLDPMVLVVTLEDLK
ASL

Nucleotide

• Length: 492 bp

>T56027 NZ_CP012146:c1246802-1246311 [Xanthomonas campestris pv. campestris]
ATGACGGTATCGGCGCCGGAACCGCTGACAGCGCATCACCGGGTCGAACCGTTCGCATCGGGCGTGGAGAGCCTGGATCA
CTGGCTCAAGCGCCGCGCCCTGAAAAATCAGGCAACCGGTGCGTCACGGACCTTCGTTGCCTGCGAGGATGACCGCGTGG
TGGCCTATTACGCCCTGGCGTCGAGTGCGGTCGCCGTGGACGCGACGCCCGGCCGCTTCCGTCGCAACATGCCGGACCCG
ATCCCCGTGGTGGTGCTTGGGAGGCTTGCTGTTGACCAATCCCTGCATGGCAGAGGTTTTGGCCGCGCCCTGATGCAGGA
TGCTGGCAAGCGCATCTTGCATGCGGCCGACACCATCGGCATTCGCGGGCTGCTCGTGCATGCGCTCTCGGCGGACGCCA
AGGCGTTTTACGAGCGCATCGGCTTCGAACCTTCCCCGCTGGATCCCATGGTGCTGGTCGTCACGCTGGAAGACCTGAAA
GCCAGTCTGTGA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10678.23 Da
• Isoelectric Point: 10.5480

>AT56027 WP_011038219.1 NZ_CP012146:c1247089-1246799 [Xanthomonas campestris pv. campestris]
MSTPNTTPGKRETLNLRIKPEERSLIDRAAKARGKNRTDFMLDAARSAAEEALLDQTLITASPDAYAAFLARLDMPPQPN
ARLRKTMQTPAPWEKA

Nucleotide

• Length: 291 bp

>AT56027 NZ_CP012146:c1247089-1246799 [Xanthomonas campestris pv. campestris]
ATGTCCACACCCAACACTACGCCTGGCAAGCGCGAAACCTTGAATCTCCGCATCAAGCCGGAGGAGCGCAGCCTGATCGA
CCGGGCCGCCAAGGCGCGCGGGAAGAACCGCACCGATTTCATGCTGGACGCAGCGCGCTCGGCGGCCGAGGAAGCCTTGC
TGGACCAGACCCTCATCACGGCCAGCCCGGACGCCTACGCCGCCTTTTTGGCACGGCTGGACATGCCGCCGCAGCCGAAC
GCGCGCCTGCGCAAGACGATGCAGACGCCCGCTCCTTGGGAGAAGGCATGA

Structures

Toxin

• AlphaFold DB: Q8P667

Antitoxin

• AlphaFold DB: Q8P668