56014

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3041719..3042373 Replicon chromosome
Accession NZ_CP012140
Organism Shigella flexneri 4c strain 1205

Toxin (Protein)


Gene name cptA Uniprot ID Q0T101
Locus tag AD871_RS16615 Protein ID WP_000244767.1
Coordinates 3041719..3042126 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID D2A730
Locus tag AD871_RS16620 Protein ID WP_000354052.1
Coordinates 3042107..3042373 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AD871_RS16595 (3037676) 3037676..3039409 - 1734 WP_000813187.1 single-stranded-DNA-specific exonuclease RecJ -
AD871_RS16600 (3039415) 3039415..3040125 - 711 WP_000715213.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
AD871_RS16605 (3040150) 3040150..3041046 - 897 WP_000806987.1 site-specific tyrosine recombinase XerD -
AD871_RS16610 (3041158) 3041158..3041679 + 522 WP_001055867.1 flavodoxin FldB -
AD871_RS16615 (3041719) 3041719..3042126 - 408 WP_000244767.1 protein YgfX Toxin
AD871_RS16620 (3042107) 3042107..3042373 - 267 WP_000354052.1 FAD assembly factor SdhE Antitoxin
AD871_RS16625 (3042616) 3042616..3043596 + 981 WP_000886062.1 tRNA-modifying protein YgfZ -
AD871_RS16630 (3043792) 3043792..3044451 - 660 WP_000250274.1 hemolysin III family protein -
AD871_RS16635 (3044615) 3044615..3044925 - 311 Protein_3054 N(4)-acetylcytidine aminohydrolase -
AD871_RS16640 (3044970) 3044970..3046403 + 1434 WP_005051722.1 6-phospho-beta-glucosidase BglA -
AD871_RS16645 (3046460) 3046460..3047203 - 744 WP_000951957.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15978.91 Da        Isoelectric Point: 10.9373

>T56014 WP_000244767.1 NZ_CP012140:c3042126-3041719 [Shigella flexneri 4c]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRCINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T56014 NZ_CP012140:c3042126-3041719 [Shigella flexneri 4c]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTATTTGATTGCG
TTCGCAGCCAGCGGTGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10519.05 Da        Isoelectric Point: 5.1599

>AT56014 WP_000354052.1 NZ_CP012140:c3042373-3042107 [Shigella flexneri 4c]
MDINNKARIHWACRRGMRELDISIMSFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEIMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT56014 NZ_CP012140:c3042373-3042107 [Shigella flexneri 4c]
ATGGACATTAACAACAAAGCCCGAATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGTCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATAATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TIU0

Antitoxin

Source ID Structure
AlphaFold DB D2A730

References