Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 2176107..2176902 | Replicon | chromosome |
| Accession | NZ_CP012140 | ||
| Organism | Shigella flexneri 4c strain 1205 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | Q93EZ7 |
| Locus tag | AD871_RS12170 | Protein ID | WP_000854917.1 |
| Coordinates | 2176107..2176481 (-) | Length | 125 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | D2ACA1 |
| Locus tag | AD871_RS12175 | Protein ID | WP_001280958.1 |
| Coordinates | 2176528..2176902 (-) | Length | 125 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AD871_RS12135 (2171716) | 2171716..2172654 | - | 939 | Protein_2219 | glyoxylate/hydroxypyruvate reductase GhrA | - |
| AD871_RS12145 (2173126) | 2173126..2173407 | - | 282 | Protein_2220 | DUF4942 domain-containing protein | - |
| AD871_RS12150 (2173689) | 2173689..2174693 | - | 1005 | WP_001179707.1 | IS110-like element ISSfl8 family transposase | - |
| AD871_RS12155 (2174765) | 2174765..2175325 | - | 561 | Protein_2222 | DUF4942 domain-containing protein | - |
| AD871_RS12160 (2175410) | 2175410..2175607 | - | 198 | WP_000839282.1 | DUF957 domain-containing protein | - |
| AD871_RS12165 (2175619) | 2175619..2176110 | - | 492 | WP_000976828.1 | DUF5983 family protein | - |
| AD871_RS12170 (2176107) | 2176107..2176481 | - | 375 | WP_000854917.1 | TA system toxin CbtA family protein | Toxin |
| AD871_RS12175 (2176528) | 2176528..2176902 | - | 375 | WP_001280958.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| AD871_RS12185 (2177065) | 2177065..2177286 | - | 222 | WP_001220314.1 | DUF987 domain-containing protein | - |
| AD871_RS12190 (2177349) | 2177349..2177825 | - | 477 | WP_005011624.1 | RadC family protein | - |
| AD871_RS12195 (2177841) | 2177841..2178314 | - | 474 | WP_005011597.1 | antirestriction protein | - |
| AD871_RS12200 (2178656) | 2178656..2179477 | - | 822 | WP_001234584.1 | DUF932 domain-containing protein | - |
| AD871_RS28955 (2179577) | 2179577..2179750 | - | 174 | WP_000088744.1 | DUF905 family protein | - |
| AD871_RS30535 (2179870) | 2179870..2180133 | - | 264 | WP_000466628.1 | DNA polymerase III subunit gamma/tau | - |
| AD871_RS12220 (2181072) | 2181072..2181488 | - | 417 | WP_000275180.1 | AraC family transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | tet(B) / ant(3'')-Ia / blaOXA-1 / catA1 | csgD / csgE / csgF / csgG | 2167402..2220361 | 52959 | |
| - | flank | IS/Tn | - | - | 2173689..2174693 | 1004 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 14145.22 Da Isoelectric Point: 7.7761
>T56013 WP_000854917.1 NZ_CP012140:c2176481-2176107 [Shigella flexneri 4c]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK
Download Length: 375 bp
>T56013 NZ_CP012140:c2176481-2176107 [Shigella flexneri 4c]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGTCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGTCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA
Antitoxin
Download Length: 125 a.a. Molecular weight: 13793.62 Da Isoelectric Point: 6.4651
>AT56013 WP_001280958.1 NZ_CP012140:c2176902-2176528 [Shigella flexneri 4c]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLYYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAPATTS
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLYYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAPATTS
Download Length: 375 bp
>AT56013 NZ_CP012140:c2176902-2176528 [Shigella flexneri 4c]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGTATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACCCGCAACCACCTCATAA
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGTATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACCCGCAACCACCTCATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | Q93EZ7 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0K4PAV2 |