Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 1657271..1657797 | Replicon | chromosome |
| Accession | NZ_CP012140 | ||
| Organism | Shigella flexneri 4c strain 1205 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | AD871_RS09165 | Protein ID | WP_000323025.1 |
| Coordinates | 1657510..1657797 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | AD871_RS09160 | Protein ID | WP_000534858.1 |
| Coordinates | 1657271..1657510 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AD871_RS09140 (1652919) | 1652919..1653122 | + | 204 | WP_000214712.1 | putative selenium delivery protein YdfZ | - |
| AD871_RS09145 (1653158) | 1653158..1654618 | - | 1461 | WP_000527804.1 | mannitol dehydrogenase family protein | - |
| AD871_RS09150 (1654707) | 1654707..1655726 | - | 1020 | Protein_1656 | MHS family MFS transporter YdfJ | - |
| AD871_RS09155 (1655788) | 1655788..1656944 | + | 1157 | Protein_1657 | IS3 family transposase | - |
| AD871_RS28745 (1656941) | 1656941..1657246 | - | 306 | WP_071818640.1 | hypothetical protein | - |
| AD871_RS09160 (1657271) | 1657271..1657510 | + | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| AD871_RS09165 (1657510) | 1657510..1657797 | + | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| AD871_RS09170 (1657869) | 1657869..1658024 | + | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| AD871_RS09175 (1658242) | 1658242..1658493 | + | 252 | WP_000980987.1 | protein Rem | - |
| AD871_RS09180 (1658560) | 1658560..1658838 | + | 279 | Protein_1663 | hypothetical protein | - |
| AD871_RS09185 (1658840) | 1658840..1659889 | + | 1050 | WP_001265249.1 | DUF968 domain-containing protein | - |
| AD871_RS09190 (1659902) | 1659902..1660258 | + | 357 | WP_000904111.1 | RusA family crossover junction endodeoxyribonuclease | - |
| AD871_RS09195 (1660273) | 1660273..1661094 | + | 822 | WP_000762882.1 | antitermination protein | - |
| AD871_RS28750 (1662015) | 1662015..1662123 | + | 109 | Protein_1667 | DUF3927 family protein | - |
| AD871_RS09220 (1662404) | 1662404..1662739 | - | 336 | WP_000871291.1 | anti-adapter protein IraM | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1654707..1673828 | 19121 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T56010 WP_000323025.1 NZ_CP012140:1657510-1657797 [Shigella flexneri 4c]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T56010 NZ_CP012140:1657510-1657797 [Shigella flexneri 4c]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT56010 WP_000534858.1 NZ_CP012140:1657271-1657510 [Shigella flexneri 4c]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT56010 NZ_CP012140:1657271-1657510 [Shigella flexneri 4c]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|