Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 1628111..1628637 | Replicon | chromosome |
| Accession | NZ_CP012137 | ||
| Organism | Shigella flexneri 2a strain 981 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | AD867_RS08930 | Protein ID | WP_000323025.1 |
| Coordinates | 1628111..1628398 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | AD867_RS08935 | Protein ID | WP_000534858.1 |
| Coordinates | 1628398..1628637 (-) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AD867_RS08875 (1623169) | 1623169..1623504 | + | 336 | WP_000871291.1 | anti-adapter protein IraM | - |
| AD867_RS30050 (1623785) | 1623785..1623893 | - | 109 | Protein_1633 | DUF3927 family protein | - |
| AD867_RS08900 (1624814) | 1624814..1625635 | - | 822 | WP_000762882.1 | antitermination protein | - |
| AD867_RS08905 (1625650) | 1625650..1626006 | - | 357 | WP_000904111.1 | RusA family crossover junction endodeoxyribonuclease | - |
| AD867_RS08910 (1626019) | 1626019..1627068 | - | 1050 | WP_001265249.1 | DUF968 domain-containing protein | - |
| AD867_RS08915 (1627070) | 1627070..1627348 | - | 279 | Protein_1637 | hypothetical protein | - |
| AD867_RS08920 (1627415) | 1627415..1627666 | - | 252 | WP_000980987.1 | protein Rem | - |
| AD867_RS08925 (1627884) | 1627884..1628039 | - | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| AD867_RS08930 (1628111) | 1628111..1628398 | - | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| AD867_RS08935 (1628398) | 1628398..1628637 | - | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| AD867_RS27415 (1628662) | 1628662..1628967 | + | 306 | WP_071818640.1 | hypothetical protein | - |
| AD867_RS27420 (1628964) | 1628964..1630120 | - | 1157 | Protein_1643 | IS3-like element IS600 family transposase | - |
| AD867_RS08945 (1630182) | 1630182..1631201 | + | 1020 | Protein_1644 | MHS family MFS transporter YdfJ | - |
| AD867_RS08950 (1631290) | 1631290..1632750 | + | 1461 | WP_000527804.1 | mannitol dehydrogenase family protein | - |
| AD867_RS08955 (1632786) | 1632786..1632989 | - | 204 | WP_000214712.1 | putative selenium delivery protein YdfZ | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1617198..1639155 | 21957 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T55975 WP_000323025.1 NZ_CP012137:c1628398-1628111 [Shigella flexneri 2a]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T55975 NZ_CP012137:c1628398-1628111 [Shigella flexneri 2a]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT55975 WP_000534858.1 NZ_CP012137:c1628637-1628398 [Shigella flexneri 2a]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT55975 NZ_CP012137:c1628637-1628398 [Shigella flexneri 2a]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|