Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 1109040..1109835 | Replicon | chromosome |
| Accession | NZ_CP012137 | ||
| Organism | Shigella flexneri 2a strain 981 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | Q93EZ7 |
| Locus tag | AD867_RS05880 | Protein ID | WP_000854917.1 |
| Coordinates | 1109461..1109835 (+) | Length | 125 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | D2ACA1 |
| Locus tag | AD867_RS05875 | Protein ID | WP_001280958.1 |
| Coordinates | 1109040..1109414 (+) | Length | 125 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AD867_RS05835 (1104454) | 1104454..1104840 | + | 387 | Protein_1067 | AraC family transcriptional regulator | - |
| AD867_RS05840 (1104929) | 1104929..1105626 | + | 698 | WP_095033700.1 | IS1-like element IS1B family transposase | - |
| AD867_RS31215 (1105809) | 1105809..1106072 | + | 264 | WP_000466628.1 | DNA polymerase III subunit gamma/tau | - |
| AD867_RS29955 (1106192) | 1106192..1106365 | + | 174 | WP_000088744.1 | DUF905 family protein | - |
| AD867_RS05850 (1106465) | 1106465..1107286 | + | 822 | WP_001234584.1 | DUF932 domain-containing protein | - |
| AD867_RS29965 (1107628) | 1107628..1108101 | + | 474 | WP_005011597.1 | antirestriction protein | - |
| AD867_RS05860 (1108117) | 1108117..1108593 | + | 477 | WP_005011624.1 | RadC family protein | - |
| AD867_RS05865 (1108656) | 1108656..1108877 | + | 222 | WP_001220314.1 | DUF987 domain-containing protein | - |
| AD867_RS05875 (1109040) | 1109040..1109414 | + | 375 | WP_001280958.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| AD867_RS05880 (1109461) | 1109461..1109835 | + | 375 | WP_000854917.1 | TA system toxin CbtA family protein | Toxin |
| AD867_RS05885 (1109832) | 1109832..1110323 | + | 492 | WP_000976828.1 | DUF5983 family protein | - |
| AD867_RS05890 (1110335) | 1110335..1110532 | + | 198 | WP_000839282.1 | DUF957 domain-containing protein | - |
| AD867_RS05895 (1110617) | 1110617..1111177 | + | 561 | Protein_1079 | DUF4942 domain-containing protein | - |
| AD867_RS05900 (1111249) | 1111249..1112253 | + | 1005 | WP_001179707.1 | IS110-like element ISSfl8 family transposase | - |
| AD867_RS05905 (1112535) | 1112535..1112816 | + | 282 | Protein_1081 | DUF4942 domain-containing protein | - |
| AD867_RS05915 (1113288) | 1113288..1114226 | + | 939 | Protein_1082 | glyoxylate/hydroxypyruvate reductase GhrA | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 1111249..1112253 | 1004 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 14145.22 Da Isoelectric Point: 7.7761
>T55972 WP_000854917.1 NZ_CP012137:1109461-1109835 [Shigella flexneri 2a]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK
Download Length: 375 bp
>T55972 NZ_CP012137:1109461-1109835 [Shigella flexneri 2a]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGTCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGTCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA
Antitoxin
Download Length: 125 a.a. Molecular weight: 13793.62 Da Isoelectric Point: 6.4651
>AT55972 WP_001280958.1 NZ_CP012137:1109040-1109414 [Shigella flexneri 2a]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLYYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAPATTS
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLYYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAPATTS
Download Length: 375 bp
>AT55972 NZ_CP012137:1109040-1109414 [Shigella flexneri 2a]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGTATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACCCGCAACCACCTCATAA
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGTATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACCCGCAACCACCTCATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | Q93EZ7 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0K4PAV2 |