Detailed information of TA system TA055817

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 2055870..2056399
• Replicon: chromosome
• Accession: NZ_CP012120
• Organism: Staphylococcus aureus strain USA300_2014.C02

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: ACO02_RS10590
• Protein ID: WP_000621175.1
• Coordinates: 2056037..2056399 (+)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: T1YCG8
• Locus tag: ACO02_RS10585
• Protein ID: WP_000948331.1
• Coordinates: 2055870..2056040 (+)
• Length: 57 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ACO02_RS10555	2050907..2051467	+	561	WP_001092411.1	K(+)-transporting ATPase subunit C	-
ACO02_RS10560	2051675..2052154	+	480	WP_001287088.1	hypothetical protein	-
ACO02_RS10565	2052147..2053730	+	1584	WP_001294626.1	PH domain-containing protein	-
ACO02_RS10570	2053717..2054208	+	492	WP_001205910.1	PH domain-containing protein	-
ACO02_RS10575	2054212..2054571	+	360	WP_000581200.1	holo-ACP synthase	-
ACO02_RS10580	2054637..2055785	+	1149	WP_001281145.1	alanine racemase	-
ACO02_RS10585	2055870..2056040	+	171	WP_000948331.1	type II toxin-antitoxin system antitoxin MazE	Antitoxin
ACO02_RS10590	2056037..2056399	+	363	WP_000621175.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
ACO02_RS10600	2056749..2057750	+	1002	WP_000390829.1	PP2C family protein-serine/threonine phosphatase	-
ACO02_RS10605	2057869..2058195	+	327	WP_001052491.1	anti-sigma factor antagonist	-
ACO02_RS10610	2058197..2058676	+	480	WP_001190829.1	anti-sigma B factor RsbW	-
ACO02_RS10615	2058651..2059421	+	771	WP_001041103.1	RNA polymerase sigma factor SigB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-110)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13441.69 Da
• Isoelectric Point: 10.1654

>T55817 WP_000621175.1 NZ_CP012120:2056037-2056399 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Nucleotide

• Length: 363 bp

>T55817 NZ_CP012120:2056037-2056399 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAGTTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin

Protein

• Length: 57 a.a.
• Molecular weight: 6251.78 Da
• Isoelectric Point: 3.8305

>AT55817 WP_000948331.1 NZ_CP012120:2055870-2056040 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Nucleotide

• Length: 171 bp

>AT55817 NZ_CP012120:2055870-2056040 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A0E0VRZ1